Release 1 - Aug 15, 2014

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Ageing Factors List

NOTE:

Ageing phenotype observations are considered as experimental analysis. They confirm or reject the ageing relevance for particular ageing factor(s). For genes that are homologous to known ageing-relevant genes there is thus far no experimental evidence. They are considered as candidate genes.
Due to the different data structures of ageing phenotype observation data integrated from other databases we subdivide these observations into type 1 and 2. Observations of type 1 contain the phenotype data mostly unseparated within a single description. Observations of type 2 contain lifespan data in a more structured form (e.g.: separated into lifespan effect, lifespan change, lifespan value). Currently there might be an overlap between the observations of type 1 and 2 from the same source, namely GenAge. But we are working on a reduction of this overlap.

Ageing Relevance:
101 ... 200 [previous icon] [next icon]
# Name Type NCBI Gene ID Species Synonyms Ageing Relevance Analysis Ageing Factor Stable ID
101 aptx gene 405797 Danio rerio Gene Synonyms:
aprataxin | aptx | FHA-HIT | forkhead-associated domain histidine triad-like protein
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000268
102 atp1 gene 2541526 Schizosaccharomyces pombe Gene Synonyms:
atp1 | F1-ATPase alpha subunit | SPAC14C4.14
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000230
103 atp2 gene 2541927 Schizosaccharomyces pombe Gene Synonyms:
atp2 | F1-ATPase beta subunit Atp2 | SPAC222.12c
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000231
104 Chrac-14 gene 3772329 Drosophila melanogaster Gene Synonyms:
55A11T | CG13399 | CG13399 gene product from transcript CG13399-RA | CG13399-PA | CG13399-PB | CG32956 | CHRAC | CHRAC-14 | Chrac-14 | Chrac-14-PA | Chrac-14-PB | CHRAC14 | Chrac14 | Dmel_CG13399 | DmelCG13399 | mary
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000145
105 dot2 gene 2541147 Schizosaccharomyces pombe Gene Synonyms:
dot2 | ESCRT II complex subunit Dot2 | SPBC651.05c | vps22
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000156
106 Eef1e1 gene 66143 Mus musculus Gene Synonyms:
Eef1e1 | elongation factor p18 | eukaryotic translation elongation factor 1 epsilon 1 | eukaryotic translation elongation factor 1 epsilon-1 | multisynthase complex auxiliary component p18 | multisynthetase complex auxiliary component p18
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000174
107 Eef2 gene 13629 Mus musculus Gene Synonyms:
Eef2 | Ef-2 | elongation factor 2 | eukaryotic translation elongation factor 2
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000176
108 Eef2 gene 29565 Rattus norvegicus Gene Synonyms:
Eef2 | Ef-2 | elongation factor 2 | elongation factor-2 | eukaryotic translation elongation factor 2
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000175
109 Egf gene 13645 Mus musculus Gene Synonyms:
Egf | epidermal growth factor | pro-epidermal growth factor | Pro-epidermal growth factor precursor (EGF)
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000179
110 Egf gene 25313 Rattus norvegicus Gene Synonyms:
Egf | epidermal growth factor | pro-epidermal growth factor
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000180
111 Egfr gene 13649 Mus musculus Gene Synonyms:
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog | Egfr | epidermal growth factor receptor | Erbb | Errb1 | Errp | RP23-295E4.1 | wa-2 | wa2 | Wa5 | waved 2
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000177
112 Egr1 gene 13653 Mus musculus Gene Synonyms:
early growth response 1 | early growth response protein 1 | egr | Egr-1 | Egr1 | ETR103 | Krox-1 | Krox-24 | Krox-24 nuclear protein | Krox24 | nerve growth factor-induced protein A | NGF1-A | NGFI-A | NGFIA | TIS8 | transcription factor Zif268 | Zenk | Zfp-6 | Zif268 | zinc finger protein Krox-24
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000168
113 Eif2s2 gene 296302 Rattus norvegicus Gene Synonyms:
Eif2s2 | eukaryotic translation initiation factor 2 subunit 2 | eukaryotic translation initiation factor 2, subunit 2 beta | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000185
114 Eif2s3x gene 26905 Mus musculus Gene Synonyms:
eIF-2-gamma X | Eif-2gx | Eif2s3x | eukaryotic translation initiation factor 2 subunit 3, X-linked | eukaryotic translation initiation factor 2 subunit gamma, X-linked | eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked | RP23-99I10.1
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000182
115 Eif3a gene 292148 Rattus norvegicus Gene Synonyms:
eIF-3-theta | Eif3a | Eif3s10 | Eif3s10_predicted | eukaryotic translation initiation factor 3 subunit 10 | eukaryotic translation initiation factor 3 subunit A | eukaryotic translation initiation factor 3, subunit 10 (theta) | eukaryotic translation initiation factor 3, subunit A | LOC292148 | ZH12
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000186
116 Eif3b gene 288516 Rattus norvegicus Gene Synonyms:
eIF-3-eta | Eif3b | Eif3s9 | Eif3s9_predicted | eukaryotic translation initiation factor 3 subunit 9 | eukaryotic translation initiation factor 3 subunit B | eukaryotic translation initiation factor 3, subunit 9 (eta) | eukaryotic translation initiation factor 3, subunit B | LOC288516 | MGC112720
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000187
117 Eif3f gene 66085 Mus musculus Gene Synonyms:
deubiquitinating enzyme eIF3f | eIF-3-epsilon | eIF3 p47 | Eif3f | Eif3s5 | eukaryotic translation initiation factor 3 subunit 5 epsilon | eukaryotic translation initiation factor 3 subunit F | eukaryotic translation initiation factor 3, subunit 5 (epsilon) | eukaryotic translation initiation factor 3, subunit F
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000188
118 Eif4a1 gene 287436 Rattus norvegicus Gene Synonyms:
Eif4a1 | eukaryotic initiation factor 4A-I | eukaryotic translation initiation factor 4A | eukaryotic translation initiation factor 4A1
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000190
119 Eif5a2 gene 310261 Rattus norvegicus Gene Synonyms:
Eif5a2 | Eif5a2_predicted | eIF5AII | eukaryotic translation initiation factor 5A2 | LOC310261
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000193
120 Eln gene 13717 Mus musculus Gene Synonyms:
elastin | Eln | tropoelastin
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000195
121 Eln gene 25043 Rattus norvegicus Gene Synonyms:
elastin | Eln | RATTREL11 | TREL11 | TRELA | Trela | Trela26 | Tropoelastin
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000194
122 Emd gene 13726 Mus musculus Gene Synonyms:
Emd | emerin | RP23-436K3.2 | Sta
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000197
123 Emd gene 25437 Rattus norvegicus Gene Synonyms:
Emd | emerin
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000198
124 Epc2 gene 227867 Mus musculus Gene Synonyms:
5830499L14 | enhancer of polycomb homolog 2 | enhancer of polycomb homolog 2 (Drosophila) | Epc2 | RP23-282J1.1
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000160
125 Epc2 gene 362132 Rattus norvegicus Gene Synonyms:
enhancer of polycomb homolog 2 | enhancer of polycomb homolog 2 (Drosophila) | Epc2 | Epc2_predicted | LOC362132
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000205
126 Epc2l1 gene 499105 Rattus norvegicus Gene Synonyms:
enhancer of polycomb homolog 2 (Drosophila)-like 1 | Epc2l1 | RGD1561337
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000204
127 Eps8 gene 13860 Mus musculus Gene Synonyms:
epidermal growth factor receptor kinase substrate 8 | epidermal growth factor receptor pathway substrate 8 | Eps8
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000207
128 Erbb2 gene 13866 Mus musculus Gene Synonyms:
avian erythroblastosis oncogene B 2 | c-erbB-2 | c-erbB2 | c-neu | ErbB-2 | Erbb-2 | Erbb2 | HER-2 | HER2 | Kiaa3023 | mKIAA3023 | Neu | Neu oncogene | p185erbB2 | proto-oncogene c-ErbB-2 | proto-oncogene NEU | receptor tyrosine-protein kinase erbB-2 | RP23-355L10.8 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000208
129 Ercc4 gene 304719 Rattus norvegicus Gene Synonyms:
Ercc4 | Ercc4 protein-like | excision repair cross-complementing rodent repair deficiency, complementation group 4 | RGD1560340
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000210
130 Ercc5 gene 301382 Rattus norvegicus Gene Synonyms:
Ercc5 | Ercc5_mapped | excision repair cross-complementing rodent repair deficiency, complementation group 5 | Xpg
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000212
131 ERG6 gene 855003 Saccharomyces cerevisiae Gene Synonyms:
ERG6 | Erg6p | ISE1 | LIS1 | SED6 | sterol 24-C-methyltransferase | VID1 | YM9571.10C | YML008C
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenDR icon]GenDR
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000133
132 Ern1 gene 498013 Rattus norvegicus Gene Synonyms:
endoplasmic reticulum (ER) to nucleus signalling 1 | endoplasmic reticulum to nucleus signaling 1 | Ern1 | RGD1559716 | serine/threonine-protein kinase/endoribonuclease IRE1
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000214
133 ERO1 gene 854909 Saccharomyces cerevisiae Gene Synonyms:
ERO1 | Ero1p | YM4987.05C | YML130C
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000149
134 ero1l gene 393321 Danio rerio Gene Synonyms:
endoplasmic oxidoreductin-1-like protein | ERO1-L | ERO1-L-alpha | ERO1-like (S. cerevisiae) | ERO1-like protein alpha | ero1l | oxidoreductin-1-L-alpha | zgc:63959
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000147
135 ERO1L gene 30001 Homo sapiens Gene Synonyms:
endoplasmic oxidoreductin-1-like protein | ERO1 (S. cerevisiae)-like | ERO1-alpha | ERO1-L | ERO1-L-alpha | ERO1-like (S. cerevisiae) | ERO1-like protein alpha | ERO1A | ERO1L | oxidoreductin-1-L-alpha | UNQ434/PRO865
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000144
136 Ero1l gene 50527 Mus musculus Gene Synonyms:
endoplasmic oxidoreductin-1-like protein | endoplasmic reticulum oxidation 1 | endoplasmic reticulum oxidoreductin-1-like protein | ERO1-L | ERO1-L-alpha | ERO1-like (S. cerevisiae) | ERO1-like protein alpha | Ero1l | oxidoreductin-1-L-alpha
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000146
137 Ero1l gene 171562 Rattus norvegicus Gene Synonyms:
endoplasmic oxidoreductin-1-like protein | ERO1-L | ERO1-L-alpha | ERO1-like (S. cerevisiae) | ERO1-like protein alpha | Ero1l | Ero1l_predicted | Giig11 | global ischemia-induced protein 11 | LOC360278 | oxidoreductin-1-L-alpha
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000148
138 ERV2 gene 856152 Saccharomyces cerevisiae Gene Synonyms:
ERV2 | Erv2p | YP3085.03C | YPR037C
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000150
139 ESC2 gene 851965 Saccharomyces cerevisiae Gene Synonyms:
ESC2 | Esc2p | YDR363W
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000153
140 ESR1 gene 2099 Homo sapiens Gene Synonyms:
ER | ER-alpha | Era | ESR | ESR1 | ESRA | estradiol receptor | estrogen nuclear receptor alpha | ESTROGEN RECEPTOR | estrogen receptor | ESTROGEN RECEPTOR 1 | estrogen receptor 1 | estrogen receptor alpha 3*,4,5,6,7*/822 isoform | estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform | estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform | estrogen receptor alpha delta 4 +49 isoform | estrogen receptor alpha delta 4*,5,6,7*/654 isoform | estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform | estrogen receptor alpha E1-E2-1-2 | estrogen receptor alpha E1-N2-E2-1-2 | ESTROGEN RECEPTOR, ALPHA | NR3A1 | nuclear receptor subfamily 3 group A member 1 | RP1-130E4.1
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000152
141 Esr1 gene 13982 Mus musculus Gene Synonyms:
ER | ER-alpha | ER[a] | ERa | ERalpha | ESR | Esr | Esr1 | Estr | Estra | estradiol receptor | estrogen receptor | estrogen receptor 1 (alpha) | Nr3a1 | nuclear receptor subfamily 3 group A member 1
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000151
142 ESS1 gene 853475 Saccharomyces cerevisiae Gene Synonyms:
ESS1 | Ess1p | J1452 | peptidylprolyl isomerase ESS1 | PIN1 | PTF1 | YJR017C
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000165
143 Etfb gene 110826 Mus musculus Gene Synonyms:
beta-ETF | electron transfer flavoprotein subunit beta | electron transferring flavoprotein, beta polypeptide | Etfb
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000219
144 Etfb gene 292845 Rattus norvegicus Gene Synonyms:
beta-ETF | electron transfer flavoprotein subunit beta | electron transferring flavoprotein, beta polypeptide | electron-transfer-flavoprotein, beta polypeptide | Etfb
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000220
145 Exosc3 gene 66362 Mus musculus Gene Synonyms:
Exosc3 | exosome complex component RRP40 | exosome complex exonuclease RRP40 | exosome component 3 | ribosomal RNA-processing protein 40 | RP23-76I24.4 | Rrp40
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000223
146 Exosc3 gene 313243 Rattus norvegicus Gene Synonyms:
Exosc3 | Exosc3_predicted | exosome complex exonuclease RRP40 | exosome component 3 | LOC313243
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000222
147 Exosc5 gene 27998 Mus musculus Gene Synonyms:
Exosc5 | exosome complex component RRP46 | exosome complex exonuclease RRP46 | exosome component 5 | ribosomal RNA-processing protein 46 | Rrp46
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000225
148 Exosc5 gene 308441 Rattus norvegicus Gene Synonyms:
Exosc5 | Exosc5_predicted | exosome complex exonuclease RRP46 | exosome component 5 | LOC308441
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000224
149 FAR10 gene 850939 Saccharomyces cerevisiae Gene Synonyms:
FAR10 | Far10p | YLR238W
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
AF_000244
150 FAR7 gene 850559 Saccharomyces cerevisiae Gene Synonyms:
FAR7 | Far7p | YFR008W
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000245
151 FAR8 gene 855044 Saccharomyces cerevisiae Gene Synonyms:
FAR8 | Far8p | YM9973.02C | YMR029C
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000246
152 FAT1 gene 852329 Saccharomyces cerevisiae Gene Synonyms:
FAT1 | Fat1p | long-chain fatty acid transporter FAT1 | YBR0411 | YBR041W
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000251
153 fbxw11a gene 334373 Danio rerio Gene Synonyms:
btrc2 | F-box and WD-40 domain protein 11 | F-box and WD-40 domain protein 11a | fbxw11 | fbxw11a | fbxw11b | fbxw1b | wu:fd14d12 | wu:fi43f07
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000228
154 fbxw11b gene 406825 Danio rerio Gene Synonyms:
btrc2 | F-box and WD-40 domain protein 11b | fbxw11 | fbxw11a | fbxw11b | wu:fa12e12 | wu:fb11f03 | zgc:63728
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000227
155 FCY1 gene 856175 Saccharomyces cerevisiae Gene Synonyms:
cytosine deaminase | FCY1 | Fcy1p | yCD | YP9499.17 | YPR062W
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
Ageing Phenotype Observation—Data Type 2 [Lifespan Observations Database icon]Lifespan Observations Database
AF_000257
156 Fen1 gene 14156 Mus musculus Gene Synonyms:
FEN-1 | Fen-1 | Fen1 | flap endonuclease 1 | flap structure specific endonuclease 1 | flap structure-specific endonuclease 1
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000262
157 Fen1 gene 84490 Rattus norvegicus Gene Synonyms:
FEN-1 | Fen1 | flap endonuclease 1 | flap structure-specific endonuclease 1 | MGC94425
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000261
158 FET3 gene 855080 Saccharomyces cerevisiae Gene Synonyms:
FET3 | Fet3p | YM9796.11 | YMR058W
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenDR icon]GenDR
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000263
159 FEZ2 gene 9637 Homo sapiens Gene Synonyms:
FASCICULATION AND ELONGATION PROTEIN ZETA 2 | fasciculation and elongation protein zeta 2 (zygin II) | fasciculation and elongation protein zeta-2 | FASCICULATION AND ELONGATION PROTEIN ZYGIN II | FEZ2 | HUM3CL | pre-T/NK cell associated protein (3Cl) | zygin 2 | zygin II | zygin-2
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000247
160 Fgf23 gene 64654 Mus musculus Gene Synonyms:
FGF-23 | Fgf23 | fibroblast growth factor 23
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000266
161 Fgf23 gene 170583 Rattus norvegicus Gene Synonyms:
FGF-23 | Fgf23 | fibroblast growth factor 23
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000265
162 Fgfr1 gene 14182 Mus musculus Gene Synonyms:
basic fibroblast growth factor receptor 1 | bFGF-R-1 | c-fgr | Eask | Fgfr-1 | Fgfr1 | fibroblast growth factor receptor 1 | FLG | Flg | Flt-2 | Hspy | MFR | proto-oncogene c-Fgr
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000173
163 Fgfr1 gene 79114 Rattus norvegicus Gene Synonyms:
basic fibroblast growth factor receptor 1 | bFGF-R | bFGF-R-1 | c-fgr | FGF receptor-1 | FGFR-1 | Fgfr1 | Fibroblast growth factor receptor 1 | fibroblast growth factor receptor 1 | Flg | MFR | proto-oncogene c-Fgr
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000264
164 FIG4 gene 855392 Saccharomyces cerevisiae Gene Synonyms:
FIG4 | Fig4p | N0330 | phosphatidylinositol-3,5-bisphosphate 5-phosphatase | YNL325C
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000269
165 FIN1 gene 851708 Saccharomyces cerevisiae Gene Synonyms:
FIN1 | Fin1p | YD9302.05C | YDR130C
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
AF_000271
166 Flt1 gene 14254 Mus musculus Gene Synonyms:
embryonic receptor kinase 2 | Emrk2 | Flt | Flt-1 | Flt1 | FMS-like tyrosine kinase 1 | sFlt1 | tyrosine-protein kinase receptor FLT | vascular endothelial growth factor receptor 1 | vascular endothelial growth factor receptor-1 | vascular permeability factor receptor | VEGFR-1 | VEGFR1 | Vegfr1
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000199
167 Fxn gene 14297 Mus musculus Gene Synonyms:
FA | FARR | frataxin | frataxin, mitochondrial | Frda | Friedreich ataxia | Fxn | X25
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000252
168 Gsk3b gene 84027 Rattus norvegicus Gene Synonyms:
FA | factor A | glycogen synthase kinase 3 beta | glycogen synthase kinase-3 beta | GSK-3 beta | Gsk3b | serine/threonine-protein kinase GSK3B
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000253
169 Ift57 gene 73916 Mus musculus Gene Synonyms:
Esrrbl1 | estrogen-related receptor beta like 1 | HIP1-interacting protein | HIPPI | Hippi | huntingtin-interacting protein-1 protein interactor | Ift57 | intraflagellar transport 57 | intraflagellar transport 57 homolog | intraflagellar transport protein 57 homolog | MHS4R2 | Vestrogen-related receptor beta like 1
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000218
170 Ift57 gene 303968 Rattus norvegicus Gene Synonyms:
Esrrbl1 | Esrrbl1_predicted | estrogen-related receptor beta like 1 | Ift57 | Ift57_predicted | intraflagellar transport 57 homolog (Chlamydomonas) | intraflagellar transport protein 57 homolog | LOC303968
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000217
171 ILK gene 3611 Homo sapiens Gene Synonyms:
59 kDa serine/threonine-protein kinase | ILK | ILK-1 | ILK-2 | ILK1 | ILK2 | INTEGRIN-LINKED KINASE | integrin-linked kinase | integrin-linked kinase-2 | integrin-linked protein kinase | P59 | p59 | p59ILK
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000169
172 MAPK1 gene 5594 Homo sapiens Gene Synonyms:
ERK | ERK-2 | ERK2 | ERT1 | EXTRACELLULAR SIGNAL-REGULATED KINASE 2 | extracellular signal-regulated kinase 2 | MAP kinase 1 | MAP kinase 2 | MAP kinase isoform p42 | MAPK 2 | MAPK1 | MAPK2 | MITOGEN-ACTIVATED PROTEIN KINASE 1 | mitogen-activated protein kinase 1 | mitogen-activated protein kinase 2 | p38 | p40 | p41 | p41mapk | p42-MAPK | P42MAPK | p42MAPK | PRKM1 | PRKM2 | PROTEIN KINASE, MITOGEN-ACTIVATED, 1 | PROTEIN KINASE, MITOGEN-ACTIVATED, 2 | PROTEIN TYROSINE KINASE ERK2 | protein tyrosine kinase ERK2
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000143
173 Mapk1 gene 116590 Rattus norvegicus Gene Synonyms:
ERK-2 | Erk2 | ERT1 | extracellular signal-regulated kinase 2 | extracellular-signal-regulated kinase 2 | MAP kinase 1 | MAP kinase 2 | MAP kinase isoform p42 | Mapk | MAPK 1 | MAPK 2 | Mapk1 | mitogen activated protein kinase 1 | mitogen-activated protein kinase 1 | mitogen-activated protein kinase 2 | p42-MAPK | Prkm1
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000139
174 mapk3 gene 399480 Danio rerio Gene Synonyms:
ERK1 | fi06b09 | mapk3 | mitogen-activated protein kinase 3 | wu:fi06b09 | zERK1
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000141
175 MAPK3 gene 5595 Homo sapiens Gene Synonyms:
ERK-1 | ERK1 | ERT2 | EXTRACELLULAR SIGNAL-REGULATED KINASE 1 | extracellular signal-regulated kinase 1 | extracellular signal-related kinase 1 | HS44KDAP | HUMKER1A | insulin-stimulated MAP2 kinase | MAP kinase 1 | MAP kinase 3 | MAP kinase isoform p44 | MAPK 1 | MAPK3 | microtubule-associated protein 2 kinase | mitogen-activated protein kinase 1 | MITOGEN-ACTIVATED PROTEIN KINASE 3 | mitogen-activated protein kinase 3 | p44-ERK1 | p44-MAPK | P44ERK1 | p44ERK1 | p44erk1 | P44MAPK | p44MAPK | p44mapk | PRKM3 | PROTEIN KINASE, MITOGEN-ACTIVATED, 3
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000138
176 Mapk3 gene 26417 Mus musculus Gene Synonyms:
Erk-1 | Erk1 | Ert2 | Esrk1 | extracellular signal-regulated kinase 1 | insulin-stimulated MAP2 kinase | MAP kinase 3 | Mapk3 | microtubule-associated protein 2 kinase | mitogen-activated protein kinase 3 | Mnk1 | Mtap2k | p44 | p44 MAP kinase | p44erk1 | p44mapk | pp42/MAP kinase | Prkm3
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000213
177 Mapk3 gene 50689 Rattus norvegicus Gene Synonyms:
Erk-1 | ERK1 | Erk1 | ERT2 | Esrk1 | extracellular signal-regulated kinase 1 | insulin-stimulated MAP2 kinase | MAP kinase 1 | MAP kinase 3 | MAP kinase isoform p44 | MAPK 1 | MAPK 3 | MAPK1 | Mapk3 | microtubule-associated protein 2 kinase | mitogen activated protein kinase 3 | mitogen-activated 3 | mitogen-activated protein kinase 1 | mitogen-activated protein kinase 3 | MNK1 | p44 | p44erk1 | p44mapk | Prkm3
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000140
178 Meis1 gene 17268 Mus musculus Gene Synonyms:
Evi8 | homeobox protein Meis1 | Meis homeobox 1 | Meis1 | myeloid ecotropic viral integration site 1 | RP23-377H12.3
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000221
179 MTOR gene 2475 Homo sapiens Gene Synonyms:
FK506 binding protein 12-rapamycin associated protein 1 | FK506 binding protein 12-rapamycin associated protein 2 | FK506-BINDING PROTEIN 12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1 | FK506-binding protein 12-rapamycin complex-associated protein 1 | FKBP-rapamycin associated protein | FKBP12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1 | FKBP12-rapamycin complex-associated protein 1 | FLJ44809 | FRAP | FRAP1 | FRAP2 | MAMMALIAN TARGET OF RAPAMYCIN | mammalian target of rapamycin | mechanistic target of rapamycin (serine/threonine kinase) | MTOR | RAFT1 | rapamycin and FKBP12 target 1 | rapamycin associated protein FRAP2 | rapamycin target protein | rapamycin target protein 1 | RAPT1 | serine/threonine-protein kinase mTOR
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000272
180 PMP2 gene 5375 Homo sapiens Gene Synonyms:
FABP8 | M-FABP | MP2 | MYELIN P2 PROTEIN | myelin P2 protein | P2 | PERIPHERAL MYELIN PROTEIN 2 | peripheral myelin protein 2 | PMP2
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000236
181 pof11 gene 2541707 Schizosaccharomyces pombe Gene Synonyms:
F-box protein Pof11 | mug156 | pof11 | SPAC29E6.01 | SPAC30.05
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000229
182 PTK2 gene 5747 Homo sapiens Gene Synonyms:
FADK | FADK 1 | FAK | FAK-related non-kinase polypeptide | FAK1 | FOCAL ADHESION KINASE | FOCAL ADHESION KINASE 1 | focal adhesion kinase 1 | focal adhesion kinase-related nonkinase | FRNK | p125FAK | pp125FAK | PPP1R71 | protein phosphatase 1 regulatory subunit 71 | protein phosphatase 1, regulatory subunit 71 | PROTEIN-TYROSINE KINASE, CYTOPLASMIC | PTK2 | PTK2 protein tyrosine kinase 2
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000241
183 Ptk2 gene 14083 Mus musculus Gene Synonyms:
Fadk | FADK 1 | FAK | Fak | fak | Fak1 | focal adhesion kinase 1 | focal adhesion kinase-related nonkinase | focal ashension kinase 1 | FRNK | Kiaa4203 | mKIAA4203 | p125FAK | pp125FAK | protein-tyrosine kinase 2 | Ptk2 | PTK2 protein tyrosine kinase 2
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000239
184 Ptk2 gene 25614 Rattus norvegicus Gene Synonyms:
FADK 1 | FAK | Fak | Fak1 | focal adhesion kinase 1 | focal adhesion kinase-related nonkinase | FRNK | p125FAK | pp125FAK | protein tyrosine kinase 2 | protein-tyrosine kinase 2 | Ptk2 | PTK2 protein tyrosine kinase 2
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000240
185 rad2 gene 2543164 Schizosaccharomyces pombe Gene Synonyms:
FEN-1 endonuclease Rad2 | fen1 | rad2 | SPAC3G6.06c
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000260
186 RTT107 gene 856559 Saccharomyces cerevisiae Gene Synonyms:
ESC4 | RTT107 | Rtt107p | YHR154W
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000154
187 SAM1 gene 850877 Saccharomyces cerevisiae Gene Synonyms:
ETH10 | L9470.9 | methionine adenosyltransferase SAM1 | SAM1 | Sam1p | YLR180W
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
Ageing Phenotype Observation—Data Type 2 [Lifespan Observations Database icon]Lifespan Observations Database
AF_000167
188 SET2 gene 853271 Saccharomyces cerevisiae Gene Synonyms:
EZL1 | J0520 | KMT3 | SET2 | Set2p | YJL168C
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000171
189 Sirt2 gene 361532 Rattus norvegicus Gene Synonyms:
5E5 antigen | MGC105900 | NAD-dependent deacetylase sirtuin-2 | NAD-dependent protein deacetylase sirtuin-2 | regulatory protein SIR2 homolog 2 | SIR2-like protein 2 | Sir2l2 | Sirt2 | sirtuin 2
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000191
190 snf8 gene 492771 Danio rerio Gene Synonyms:
ESCRT-II complex subunit VPS22 | si:dkey-220f10.1 | snf8 | SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) | vacuolar sorting snf8 ELL associated of 30kDa | vacuolar-sorting protein SNF8 | zgc:101578
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000162
191 sst4 gene 2542403 Schizosaccharomyces pombe Gene Synonyms:
ESCRT 0 complex subunit sst4 | SPAC19A8.05c | sst4 | vps27
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000155
192 TBC1D24 gene 57465 Homo sapiens Gene Synonyms:
FIME | KIAA1171 | TBC1 domain family member 24 | TBC1 DOMAIN FAMILY, MEMBER 24 | TBC1 domain family, member 24 | TBC1D24
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000270
193 Tert gene 21752 Mus musculus Gene Synonyms:
EST2 | TCS1 | telomerase catalytic subunit | telomerase reverse transcriptase | telomerase reverse transcriptase beta | Tert | TP2 | TR | TRT
Source: [GPSDB icon]GPSDB
Ageing Phenotype Observation—Data Type 1 [GenAge icon]GenAge
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
Ageing Phenotype Observation—Data Type 2 [Lifespan Observations Database icon]Lifespan Observations Database
AF_000166
194 vps20 gene 2540725 Schizosaccharomyces pombe Gene Synonyms:
ESCRT III complex subunit Vps20 | SPBC215.14c | vps20
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000158
195 vps24 gene 2542234 Schizosaccharomyces pombe Gene Synonyms:
ESCRT III complex subunit Vps24 | SPAC9E9.14 | vps24
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000159
196 vps36 gene 335810 Danio rerio Gene Synonyms:
ESCRT-II complex subunit VPS36 | fj33d07 | vacuolar protein sorting 36 homolog (S. cerevisiae) | vacuolar protein-sorting-associated protein 36 | vps36 | wu:fj33d07 | zgc:55965
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000164
197 Vps36 gene 70160 Mus musculus Gene Synonyms:
Eap45 | ESCRT-II complex subunit VPS36 | vacuolar protein sorting 36 (yeast) | vacuolar protein-sorting-associated protein 36 | Vps36
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000163
198 VPS37B gene 79720 Homo sapiens Gene Synonyms:
ESCRT-I complex subunit VPS37B | FLJ12750 | hVps37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | VACUOLAR PROTEIN SORTING 37, YEAST, HOMOLOG OF, B | vacuolar protein sorting 37B | vacuolar protein sorting 37B (yeast) | vacuolar protein sorting-associated protein 37B | VPS37B
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000161
199 Ywhaz gene 22631 Mus musculus Gene Synonyms:
14-3-3 protein zeta/delta | 14-3-3 zeta | 14-3-3zeta | KCIP-1 | protein kinase C inhibitor protein 1 | SEZ-2 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | Ywhaz
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000200
200 Ywhaz gene 25578 Rattus norvegicus Gene Synonyms:
14-3-3 protein zeta/delta | 14-3-3z | KCIP-1 | mitochondrial import stimulation factor S1 subunit | Msfs1 | protein kinase C inhibitor protein 1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | Ywhaz
Source: [GPSDB icon]GPSDB
Homology Analysis Data [putative] [AgeFactDB Homology Analysis icon]AgeFactDB Homology Analysis
AF_000235