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Ageing Phenotype Observations List—Data Type 2

NOTE:

We distinguish between different types of ageing relevance evidence. Experimental studies on ageing factors result in observations with experimental ageing relevance evidence (1). According to our definition of ageing factors a comparison of two situations, with and without the action of the ageing factor, is required. Almost all data in AgeFactDB is of this type. There are however also a few lifespan data for populations or species included that are certainly relevant to ageing with a slightly different meaning of the term ageing relevance, however. But in this case there is no intervention study and therefore these data cannot be assigned to an ageing factor (2). Furthermore, there are experimental studies where no significant effect of an assumed ageing factor was found (3). And finally there are genes included that are homologous to known ageing-relevant genes for which there is no experimental evidence. They are considered as putative ageing-relevant genes with computational evidence (4).
Order of importance:

  1. yes (Experimental Analysis)
  2. yes, but no ageing factor assigned (Experimental Analysis)
  3. no (Experimental Analysis)
  4. putative (Computational Analysis)
The color indicating the ageing relevance type of an observation may differ from the corresponding color for the ageing factor related to this observation. The reason is that for ageing factors associated with more than one observation, the most important observation color is chosen as ageing factor color. This is always the color with the lowest number in the order given above.

Ageing phenotype observations are considered as experimental analysis. They confirm or reject the ageing relevance for particular ageing factor(s). For genes that are homologous to known ageing-relevant genes there is thus far no experimental evidence. They are considered as candidate genes.
Due to the different data structures of ageing phenotype observation data integrated from other databases we subdivide these observations into type 1 and 2. Observations of type 1 contain the phenotype data mostly unseparated within a single description. Observations of type 2 contain lifespan data in a more structured form (e.g.: separated into lifespan effect, lifespan change, lifespan value). Currently there might be an overlap between the observations of type 1 and 2 from the same source, namely GenAge. But we are working on a reduction of this overlap.

Ageing Relevance:
101 ... 200 [previous icon] [next icon]
Organism Ageing Factor Lifespan Observation Reference
# Observation Stable ID Species Strain Gene Compound Other Ageing Factor Significant Lifespan Effect Change Observed Lifespan Reference Lifespan Lifespan Unit Measure Temperature Temperature Unit Sex/Mating Type Description Author Year PubMed DOI Source
101 OB_000155 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 76.63% 46.1 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1167)
102 OB_000116 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.005% glucose
increased 76.52% 43.6 24.7 30 ℃ matalpha Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. Kaeberlein et al. 2006 16741098 [DOI icon]doi:10.1126/science.1124608 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1126)
103 OB_000151 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 75.86% 45.9 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1163)
104 OB_000117 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
HXK2 Saccharomyces cerevisiae 852639 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
increased 70.82% 43.9 25.7 30 ℃ matalpha Deletion of HXK2 significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from deletion of HXK2. Deletion of HXK2 is proposed as a genetic mimic of dietary restriction [[PubMed icon] 11000115]. Kaeberlein et al. 2006 16741098 [DOI icon]doi:10.1126/science.1124608 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1127)
105 OB_000115 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 70.45% 42.1 24.7 30 ℃ matalpha Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. Kaeberlein et al. 2006 16741098 [DOI icon]doi:10.1126/science.1124608 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1125)
106 OB_000144 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 68.20% 43.9 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1157)
107 OB_000161 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.005% glucose
increased 67.05% 43.6 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1172)
108 OB_000160 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 61.30% 42.1 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1171)
109 OB_000110 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 61.17% 44 27.3 divisions mean 30 ℃ matalpha Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1120)
110 OB_000145 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.005% glucose
increased 57.09% 41 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1158)
111 OB_000150 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 53.64% 40.1 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1162)
112 OB_000193 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SIS2 Saccharomyces cerevisiae 853946 deletion / null - unknown unknown
increased 46.60% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1200)
113 OB_000105 Saccharomyces cerevisiae PSY316AUT
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CYT1 Saccharomyces cerevisiae 854231 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 45.00% 29 20 divisions mean 30 ℃ matalpha Dietary restriction at either 0.5% or 0.05% glucose increases the replicative life span of CYT1 deletion mutants in the PSY316AUT strain background, demonstrating that mitochondrial respiration is not required for life span extension from dietary restriction. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1113)
114 OB_000175 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SPT4 Saccharomyces cerevisiae 852955 deletion / null - unknown unknown
increased 40.90% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1185)
115 OB_000190 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SCH9 Saccharomyces cerevisiae 856612 deletion / null - unknown unknown
increased 40.00% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1199)
116 OB_000188 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
PMR1 Saccharomyces cerevisiae 852709 deletion / null - unknown unknown
increased 37.00% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1197)
117 OB_000177 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TIF2 Saccharomyces cerevisiae 853303 deletion / null - unknown unknown
increased 33.80% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1187)
118 OB_000183 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
DBP3 Saccharomyces cerevisiae 852802 deletion / null - unknown unknown
increased 33.60% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1192)
119 OB_000194 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TIS11 Saccharomyces cerevisiae 850827 deletion / null - unknown unknown
increased 32.20% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1201)
120 OB_000195 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YGR130C Saccharomyces cerevisiae 853031 deletion / null - unknown unknown
increased 31.90% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1202)
121 OB_000148 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 5 millimolar
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 31.03% 34.2 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1160)
122 OB_000172 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
INP53 Saccharomyces cerevisiae 854276 deletion / null - unknown unknown
increased 30.70% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1182)
123 OB_000196 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YPT6 Saccharomyces cerevisiae 850966 deletion / null - unknown unknown
increased 30.30% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1203)
124 OB_000163 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 29.89% 33.9 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1174)
125 OB_000176 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TIF1 Saccharomyces cerevisiae 853933 deletion / null - unknown unknown
increased 29.30% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1186)
126 OB_000173 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL19A Saccharomyces cerevisiae 852379 deletion / null - unknown unknown
increased 28.40% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1183)
127 OB_000200 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SIS2 Saccharomyces cerevisiae 853946 deletion / null - unknown unknown
increased 27.70% divisions mean 30 ℃ mata From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1207)
128 OB_000114 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.5% glucose
increased 26.72% 31.3 24.7 30 ℃ matalpha Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. Kaeberlein et al. 2006 16741098 [DOI icon]doi:10.1126/science.1124608 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1124)
129 OB_000199 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TIS11 Saccharomyces cerevisiae 850827 deletion / null - unknown unknown
increased 25.70% divisions mean 30 ℃ mata From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1206)
130 OB_000184 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
HSE1 Saccharomyces cerevisiae 856387 deletion / null - unknown unknown
increased 25.50% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1193)
131 OB_000108 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 5 millimolar
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 25.27% 34.2 27.3 divisions mean 30 ℃ matalpha Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1119)
132 OB_000182 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
ALG12 Saccharomyces cerevisiae 855764 deletion / null - unknown unknown
increased 24.70% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1191)
133 OB_000119 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
HXK2 Saccharomyces cerevisiae 852639 deletion / null - unknown unknown
increased 24.12% 31.9 25.7 30 ℃ matalpha Deletion of HXK2 significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from deletion of HXK2. Deletion of HXK2 is proposed as a genetic mimic of dietary restriction [[PubMed icon] 11000115]. Kaeberlein et al. 2006 16741098 [DOI icon]doi:10.1126/science.1124608 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1129)
134 OB_000170 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
AFG3 Saccharomyces cerevisiae 856737 deletion / null - unknown unknown
increased 23.30% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1180)
135 OB_000181 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
ADH1 Saccharomyces cerevisiae 854068 deletion / null - unknown unknown
increased 23.20% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1190)
136 OB_000187 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
PKH2 Saccharomyces cerevisiae 854053 deletion / null - unknown unknown
increased 22.20% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1196)
137 OB_000178 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TIF4631 Saccharomyces cerevisiae 853071 deletion / null - unknown unknown
increased 21.20% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1188)
138 OB_000179 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
increased 20.30% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1189)
139 OB_000159 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.5% glucose
increased 19.92% 31.3 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1170)
140 OB_000198 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YGR130C Saccharomyces cerevisiae 853031 deletion / null - unknown unknown
increased 19.20% divisions mean 30 ℃ mata From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1205)
141 OB_000189 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SAM1 Saccharomyces cerevisiae 850877 deletion / null - unknown unknown
increased 18.90% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1198)
142 OB_000143 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.5% glucose
increased 17.62% 30.7 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1156)
143 OB_000171 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
IDH2 Saccharomyces cerevisiae 854303 deletion / null - unknown unknown
increased 17.30% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1181)
144 OB_000185 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
IDH1 Saccharomyces cerevisiae 855691 deletion / null - unknown unknown
increased 16.20% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1194)
145 OB_000154 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
hst3 Saccharomyces cerevisiae 854190 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 15.33% 30.1 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1166)
146 OB_000104 Saccharomyces cerevisiae PSY316AUT
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CYT1 Saccharomyces cerevisiae 854231 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.5% glucose
increased 15.00% 23 20 divisions mean 30 ℃ matalpha Dietary restriction at either 0.5% or 0.05% glucose increases the replicative life span of CYT1 deletion mutants in the PSY316AUT strain background, demonstrating that mitochondrial respiration is not required for life span extension from dietary restriction. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1112)
147 OB_000103 Saccharomyces cerevisiae PSY316AUT
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CYT1 Saccharomyces cerevisiae 854231 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
rho0 Absence of mitochondrial DNA.
increased 14.62% 24.3 21.2 divisions mean 30 ℃ matalpha PSY316AUT rho0 cells also deleted for CYT1 are short-lived, but still have their life span extended by dietary restriction. These data demonstrate that mitochondrial respiration is not required for life span extension from dietary restriction in the PSY316AUT strain background. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1111)
148 OB_000174 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL6B Saccharomyces cerevisiae 851169 deletion / null - unknown unknown
increased 13.90% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1184)
149 OB_000186 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
INP51 Saccharomyces cerevisiae 854815 deletion / null - unknown unknown
increased 13.20% divisions mean 30 ℃ matalpha From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1195)
150 OB_000152 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
increased 11.11% 29 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1164)
151 OB_000197 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YPT6 Saccharomyces cerevisiae 850966 deletion / null - unknown unknown
increased 10.70% divisions mean 30 ℃ mata From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. Smith et al. 2008 18340043 [DOI icon]doi:10.1101/gr.074724.107 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1204)
152 OB_000162 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
increased 6.51% 27.8 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1173)
153 OB_000157 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
increased 6.13% 27.7 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1169)
154 OB_000146 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 5 millimolar
increased 5.75% 27.6 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1159)
155 OB_000118 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
increased 5.06% 27 25.7 30 ℃ matalpha Deletion of HXK2 significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from deletion of HXK2. Deletion of HXK2 is proposed as a genetic mimic of dietary restriction [[PubMed icon] 11000115]. Kaeberlein et al. 2006 16741098 [DOI icon]doi:10.1126/science.1124608 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1128)
156 OB_000142 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
none 3.45% 27 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1155)
157 OB_000113 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
none 2.83% 25.4 24.7 30 ℃ matalpha Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. Kaeberlein et al. 2006 16741098 [DOI icon]doi:10.1126/science.1124608 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1123)
158 OB_000165 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 5 millimolar
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
none 2.30% 26.7 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1176)
159 OB_000149 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
none 1.15% 26.4 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1161)
160 OB_000111 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 5 millimolar
none 1.10% 27.6 27.3 divisions mean 30 ℃ matalpha Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1121)
161 OB_000112 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
none 0.73% 27.5 27.3 divisions mean 30 ℃ matalpha Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1122)
162 OB_000130 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
none 0.38% 26.2 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1144)
163 OB_000131 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
none 0.38% 26.2 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1145)
164 OB_000168 Saccharomyces cerevisiae W303AR5
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
none 0.00% 24.4 24.4 divisions mean 30 ℃ mata Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1179)
165 OB_000121 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
none -0.76% 26.2 26.4 divisions mean 30 ℃ matalpha Deletion of HST1, HST2, or HST4 had no effect on replicative life span of BY4742 mother cells. Deletion of either SIR2 or HST3 shortened life span. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1133)
166 OB_000122 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
none -0.76% 26.2 26.4 divisions mean 30 ℃ matalpha Deletion of HST1, HST2, or HST4 had no effect on replicative life span of BY4742 mother cells. Deletion of either SIR2 or HST3 shortened life span. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1134)
167 OB_000101 Saccharomyces cerevisiae YPK9
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CIT2 Saccharomyces cerevisiae 850361 deletion / null - unknown unknown
none -1.10% 18 18.2 divisions mean 30 ℃ mata Deletion of CIT2 has no effect on life-span. Other phenotypes: Overexpression of CIT2 has no effect on life-span [[PubMed icon] 10224252]. CIT2 is not required for the strain specific life-span extension in petite cells. CIT2 is transcribed up to 30-fold higher in petite cells relative to grande cells [[PubMed icon] 1986232]. Kirchman et al. 1999 10224252 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 110)
168 OB_000124 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
none -2.27% 25.8 26.4 divisions mean 30 ℃ matalpha Deletion of HST1, HST2, or HST4 had no effect on replicative life span of BY4742 mother cells. Deletion of either SIR2 or HST3 shortened life span. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1136)
169 OB_000164 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 5 millimolar
none -2.30% 25.5 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1175)
170 OB_000138 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
none -2.68% 25.4 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1151)
171 OB_000126 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
none -3.94% 24.4 25.4 divisions mean 30 ℃ matalpha Deletion of HST2 had no effect on replicative life span of W303AR5 mother cells. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1138)
172 OB_000156 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
decreased -13.79% 22.5 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1168)
173 OB_000123 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst3 Saccharomyces cerevisiae 854190 deletion / null - unknown unknown
decreased -28.79% 18.8 26.4 divisions mean 30 ℃ matalpha Deletion of HST1, HST2, or HST4 had no effect on replicative life span of BY4742 mother cells. Deletion of either SIR2 or HST3 shortened life span. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1135)
174 OB_000132 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst3 Saccharomyces cerevisiae 854190 deletion / null - unknown unknown
decreased -32.95% 17.5 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1146)
175 OB_000153 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
hst3 Saccharomyces cerevisiae 854190 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
decreased -36.02% 16.7 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1165)
176 OB_000106 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 5 millimolar
decreased -44.14% 14.3 25.6 divisions mean 30 ℃ matalpha Addition of 5 mM nicotinamide shortens replicative life span in the BY4742 strain background to the same extent as deletion of SIR2. The combination of SIR2 deletion with 5 mM nicotinamide does not further shorten life span. This indicates that 5 mM nicotinamide is likely reducing life span by inhibition of SIR2. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1116)
177 OB_000102 Saccharomyces cerevisiae PSY316AUT
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CYT1 Saccharomyces cerevisiae 854231 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
rho0 Absence of mitochondrial DNA.
decreased -45.28% 11.6 21.2 divisions mean 30 ℃ matalpha PSY316AUT rho0 cells also deleted for CYT1 are short-lived, but still have their life span extended by dietary restriction. These data demonstrate that mitochondrial respiration is not required for life span extension from dietary restriction in the PSY316AUT strain background. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1110)
178 OB_000107 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
decreased -47.27% 13.5 25.6 divisions mean 30 ℃ matalpha Addition of 5 mM nicotinamide shortens replicative life span in the BY4742 strain background to the same extent as deletion of SIR2. The combination of SIR2 deletion with 5 mM nicotinamide does not further shorten life span. This indicates that 5 mM nicotinamide is likely reducing life span by inhibition of SIR2. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1118)
179 OB_000125 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
decreased -47.35% 13.9 26.4 divisions mean 30 ℃ matalpha Deletion of HST1, HST2, or HST4 had no effect on replicative life span of BY4742 mother cells. Deletion of either SIR2 or HST3 shortened life span. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1137)
180 OB_000128 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
decreased -48.66% 13.4 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1142)
181 OB_000137 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 5 millimolar
decreased -49.43% 13.2 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1150)
182 OB_000129 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 5 millimolar
decreased -54.02% 12 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1143)
183 OB_000135 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 25 millimolar
decreased -72.80% 7.1 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1149)
184 OB_000166 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
hst3 Saccharomyces cerevisiae 854190 deletion / null - unknown unknown
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
decreased -73.56% 6.9 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1177)
185 OB_000167 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
HST1 Saccharomyces cerevisiae 854086 deletion / null - unknown unknown
HST2 Saccharomyces cerevisiae 856092 deletion / null - unknown unknown
hst3 Saccharomyces cerevisiae 854190 deletion / null - unknown unknown
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
decreased -75.10% 6.5 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1178)
186 OB_000139 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst3 Saccharomyces cerevisiae 854190 deletion / null - unknown unknown
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
decreased -78.54% 5.6 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1152)
187 OB_000133 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst3 Saccharomyces cerevisiae 854190 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 5 millimolar
decreased -83.52% 4.3 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1147)
188 OB_000134 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst3 Saccharomyces cerevisiae 854190 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 25 millimolar
decreased -83.91% 4.2 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1148)
189 OB_000141 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst3 Saccharomyces cerevisiae 854190 deletion / null - unknown unknown
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 25 millimolar
decreased -84.67% 4 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1154)
190 OB_000140 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hst3 Saccharomyces cerevisiae 854190 deletion / null - unknown unknown
hst4 Saccharomyces cerevisiae 851772 deletion / null - unknown unknown
Compound Name Quantity Quantity Unit
Nicotinamide 5 millimolar
decreased -85.82% 3.7 26.1 divisions mean 30 ℃ matalpha Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. Tsuchiya et al. 2006 17129213 [DOI icon]doi:10.1111/j.1474-9726.2006.00240.x [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1153)
191 OB_000109 Mus musculus R722W/R722W
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
Ercc2 Mus musculus 13871 non-null recessive - unknown unknown
decreased Homozygous mutation of XPD results in an extreme shortening of life-span (mean life-span = 7 months) relative to wild type (mean life-span > 24 months). Other phenotypes: The shortened life span of the mutant mouse is accompanied by symptoms of premature aging including including osteoporosis, early graying, cachexia, and infertility [[PubMed icon] 11950998]. Mouse model for the brittle hair disorder trichothiodystrophy (TTD). Phenotypes include brittle hair, UV sensitivity, and developmental defects [[PubMed icon] 9651581]. de Boer et al. 2002 11950998 [DOI icon]doi:10.1126/science.1070174 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 111)
192 OB_000120 Mus musculus 129Ola and BalbC
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
GHR Mus musculus deletion / null - unknown unknown
increased Mice homozygous for disruption of GHR/BP have a life-span that is 40-50% longer than wild type or heterozygous mice. Other phenotypes: The GHR/BP knockout mouse is a model for the rare human disease Laron syndrome [[PubMed icon] 9371826]. Serum levels of GH are elevated in mutant mice [[PubMed icon] 9371826]. Mutant mice are smaller than wild type mice. IGF-I and IGFBP-3 levels are also reduc Coschigano et al. 2000 10875265 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 112)
193 OB_000127 Homo sapiens MRC-5 lung fibroblasts
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
Mot-2 Homo sapiens over-expression - unknown unknown
increased Transfection of normal human fiboblasts with human or murine Mot-2 overexpression vectors led to an increase in the number of population doublings the cells could sustain before senescing (percent increase varying from 32% to 60%, depending on the exact construct used). Other phenotypes: Mot-2 is an hsp70 family member found to be differentially distributed and/or translated in normal vs. transformed cells [[PubMed icon] 8454632]. Mot-2 overexpressing cells exhibited a reduction in p53 transcriptional activation, as measured by expression from vectors containing either luciferase or beta-galactosidase driven by p53 binding sites [[PubMed icon] 10838077]. Furthermore, the transfected cells retained a youthful morphology longer than the control cells, and there was a delay in appearance of senescence associated beta-galactosidase activity [[PubMed icon] 10838077]. Wadhwa et al. 1993 8454632 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 113)
194 OB_000136 Caenorhabditis elegans Bristol N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hsp-6 Caenorhabditis elegans 178873 over-expression - unknown unknown
increased Overexpression of hsp70F from a muscle-specific promoter increased life-span (mean increase: 43%, maximum increase: 45%) relative to animals expressing GFP from the same promoter. Other phenotypes: C. elegans hsp70F is the homolog of mammalian mortalin (mot-2/mthsp70/Grp75) [[PubMed icon] 2766926], which has been shown to be capable of increasing the proliferative potential of normal fibroblasts when overexpressed [[PubMed icon] 10838077]. The hsp70F transgene was integrated into the genome, not an extrachromosomal array. It was confirmed immunohistochemically to be expressed predominantly in muscle [[PubMed icon] 11959102]. Yokoyama et al. 2002 11959102 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 114)
195 OB_000147 Caenorhabditis elegans Bristol N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
clk-1 Caenorhabditis elegans 175729 non-null recessive - unknown unknown
daf-2 Caenorhabditis elegans 175410 non-null recessive - unknown unknown
increased Mutation of both clk-1 and daf-2 results in a nearly 5-fold (500%) increase in life-span. Other phenotypes: Overexpression of clk-1 increases mitochondrial activity and shortens life-span [[PubMed icon] 10202142]. Loss of function mutation increases adult life-span by 30% [[PubMed icon] 8638122]. Mutations in clk-1 are highly pleiotropic resulting in an average lengthening of embryonic development, post-embryonic development, and adult rhythmic behaviors such as defecation, swimming, and pharyngeal pumping [[PubMed icon] 7768437]. Lakowski et al. 1996 8638122 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 115)
196 OB_000158 Caenorhabditis elegans Bristol N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
clk-1 Caenorhabditis elegans 175729 non-null recessive - unknown unknown
increased Loss of function mutation increases adult life-span by 30%. Other phenotypes: Mutation of both clk-1 and daf-2 results in a nearly 5-fold (500%) increase in life-span [[PubMed icon] 8638122]. Overexpression of clk-1 increases mitochondrial activity and shortens life-span [[PubMed icon] 10202142]. Mutations in clk-1 are highly pleiotropic resulting in an average lengthening of embryonic development, post-embryonic development, and adult rhythmic behaviors such as defecation, swimming, and pharyngeal pumping [[PubMed icon] 7768437]. Lakowski et al. 1996 8638122 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 116)
197 OB_000169 Saccharomyces cerevisiae PSY316
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
HAP4 Saccharomyces cerevisiae 853751 over-expression - unknown unknown
increased Overexpression of HAP4 from the ADH1 promoter extends life-span approximately 40% under growth conditions favoring fermentation (2% glucose). Other phenotypes: Overexpression of HAP4 combined with calorie restriction (CR) fails to further extend life-span. Like CR, life-span extension by HAP4 requires SIR2. HAP4 overexpressing cells demonstrate a transcriptional response resembling cells undergoing diauxic shift, consume more oxygen than wild type cells, and show increased Sir2p-dependent transcriptional silencing at telomeres and rDNA [[PubMed icon] 12124627]. Lin et al. 2002 12124627 [DOI icon]doi:10.1038/nature00829 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 117)
198 OB_000180 Saccharomyces cerevisiae PSY316
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CYT1 Saccharomyces cerevisiae 854231 deletion / null - unknown unknown
none Deletion of CYT1 has no effect on life-span, but prevents life-span extension by overexpression of HAP4. Other phenotypes: CYT1 is required for respiration in yeast. Lin et al. 2002 12124627 [DOI icon]doi:10.1038/nature00829 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 118)
199 OB_000191 Saccharomyces cerevisiae SP-4
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SOD1 Saccharomyces cerevisiae 853568 deletion / null - unknown unknown
decreased Deletion of Cu-Zn superoxide dismutase decreases replicative life-span by approximately 40%. Other phenotypes: The magnitude of the decrease in life-span does not appear to be dependent on oxygen concentration in the atmosphere [[PubMed icon] 12020810]. Deletion of SOD1 shortens chronological life-span as well as replicative life span [[PubMed icon] 10222047]. Overexpression of SOD1 has no effect on replicative life-span [[PubMed icon] 10224252]. Wawryn et al. 2002 12020810 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 119)
200 OB_000192 Saccharomyces cerevisiae S150-2B
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
PHB2 Saccharomyces cerevisiae 853146 deletion / null - unknown unknown
decreased Deletion of both PHB1 and PHB2 results in a life span that is approximately 40% shorter than wild type. Other phenotypes: Deletion of PHB1 results in approximately 20% shorter lifespan. Phenotypic changes characteristic of aging cells may suggest that PHB1/PHB2 mutants undergo premature aging, not simply reduction in viability. These changes include lengthening of cell cycle and characteristic morphological changes [[PubMed icon] 9259555]. No reduction in stress resistance or bulk growth rate. A strong defect in mitochondrial potential was detected in the phb1 phb2 double mutant., and a slight defect in the phb1 single mutant [[PubMed icon] 9259555]. Coates et al. 1997 9259555 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 11)