101 |
OB_005717 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
PHB1 |
853033 |
|
|
Deletion results in a reduction in mean and maximum replicative lifespan and a defect in mitochondrial membrane potential. |
9259555 |
GenAge |
102 |
OB_005720 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
PHB2 |
853146 |
|
|
Deletion results in a reduction in mean and maximum replicative lifespan and a defect in mitochondrial membrane potential. |
9259555 |
GenAge |
103 |
OB_005723 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
PHB2 |
853146 |
|
|
Two classes of prohibitin dependent mutation (pbd1 and pbd2) were isolated and characterised. The effect of these mutations on replicative lifespan was determined, demonstrating that the pbd1 mutant slightly extended lifespan by 11%, whereas in contrast, the pbd2 mutation resulted in a shortening in both the mean- and the maximum-lifespan by (28 and 17%, respectively). The pbd1 mutation was also found to reduce chronological lifespan. Reducing the expression of the PHB2 gene in the pbd mutants was found to retard the rate of growth and to affect replicative lifespan. As the two mutants behave in a different manner they probably affect different aspects of prohibitin function. |
16710639 |
GenAge |
104 |
OB_005728 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Plau |
18792 |
|
|
Overexpression in the brain of transgenic mice resulted in less food consumption (20%), reduced body weight (20%), reduced temperature, and a prolonged lifespan (20%). |
10638529 |
GenAge |
105 |
OB_005731 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
pnk-1 |
172327 |
|
|
RNAi let to a 42% decrease in median lifespan in daf-2 background and a 18% decrease in lifespan in daf-2/daf-16 double mutant background. |
18006689 |
GenAge |
106 |
OB_005733 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Bub3 |
12237 |
|
|
Haploinsufficiency of Bub3 and Rae1, but not haploinsufficiency of either gene by itself, reduces lifespan by 12% and appears to accelerate ageing. |
16476774 |
GenAge |
107 |
OB_005735 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Polg |
18975 |
|
|
Mice with a proof-reading-deficient version of Polg display an increased amount of mtDNA mutations and signs of premature ageing including a reduced lifespan, weight loss, reduced subcutaneous fat, alopecia, kyphosis, osteoporosis, anaemia, reduced fertility, and heart enlargement. |
15164064 |
GenAge |
108 |
OB_005737 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Polg |
18975 |
|
|
Mice with a proofreading-deficient version of the mitochondrial DNA polymerase g (POLG) resulted in premature aging and cancer. |
16020738 |
GenAge |
109 |
OB_005741 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Ppm1d |
53892 |
|
|
Knockout mice are resistant to spontaneous tumors but show a modest reduction in lifespan and reduced body weight. |
16652371 |
GenAge |
110 |
OB_005743 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
prdx-2 |
266858 |
|
|
RNA interference resulted in decreased lifespan and earlier accumulation of lipofuscin. |
16673436 |
GenAge |
111 |
OB_005745 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
prdx-3 |
175573 |
|
|
RNA interference resulted in decreased lifespan and earlier accumulation of lipofuscin. |
16673436 |
GenAge |
112 |
OB_005748 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Prdx1 |
18477 |
|
|
Knockout mice have a shortened lifespan and develop severe haemolytic anaemia and several malignant cancers. |
12891360 |
GenAge |
113 |
OB_005750 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Prop1 |
19127 |
|
|
Knockouts are dwarf but live approximately 1 year longer than controls. |
8900272 |
GenAge |
114 |
OB_005754 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
ptr-23 |
173362 |
|
|
RNA interference decreased median lifespan by 13% in wild type animals and 37% in daf-2 mutants. |
18006689 |
GenAge |
115 |
OB_005756 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
puc |
40958 |
|
|
Heterozygous loss-of-function mutations extend lifespan and increase resistance to oxidative stress. |
14602080 |
GenAge |
116 |
OB_005760 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
R11A5.4 |
172556 |
|
|
RNA interference increased mean lifespan by 11% in daf-2 mutants but had no significant effect on wild type animals. |
17673661 |
GenAge |
117 |
OB_005765 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
R12B2.6 |
187837 |
|
|
RNA interference decreased median lifespan by 22% in wild type animals and 24% in daf-2 mutants. |
18006689 |
GenAge |
118 |
OB_005768 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
rab-7 |
174834 |
|
|
RNA interference decreased median lifespan by 32% in wild type animals, 48% in a daf-2 background and 18% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
119 |
OB_005770 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
C01F1.1 |
173764 |
|
|
RNA interference decreased median lifespan by 28% in wild type animals, 37% in a daf-2 background and 14% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
120 |
OB_005772 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
RAD27 |
853747 |
|
|
Mutations result in signs of premature ageing. |
12024027 |
GenAge |
121 |
OB_005781 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
RAD9 |
851803 |
|
|
Deletion results in mutants with a 2-fold decrease in mean and maximum chronological lifespan under conditions of nutrient depletion. |
17710147 |
GenAge |
122 |
OB_005782 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Rae1 |
66679 |
|
|
Haploinsufficiency of Bub3 and Rae1, but not haploinsufficiency of either gene by itself, reduces lifespan by 12% and appears to accelerate ageing. |
16476774 |
GenAge |
123 |
OB_005796 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
rhi-1 |
180721 |
|
|
RNA interference resulted in decreased lifespan and earlier accumulation of lipofuscin. |
16673436 |
GenAge |
124 |
OB_005798 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
rho-7 |
36281 |
|
|
Knockout flies have severe neurological defects and a much reduced lifespan. |
16713954 |
GenAge |
125 |
OB_005806 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
rle-1 |
176525 |
|
|
Disruption of rle-1 extended maximum lifespan by about 30%, dependent on daf-16 since disruption of daf-16 in rle-1 mutants reversed the life-extending effects. Overexpression of daf-16 in rle-1 mutants further increased lifespan. Disrupted of rle-1 also resulted in partial embryonic lethality and fewer progeny. |
17276341 |
GenAge |
126 |
OB_005814 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
RPD3 |
855386 |
|
|
Deletion extended lifespan by 41%, independently of an intact Sir silencing complex. |
10512855 |
GenAge |
127 |
OB_005822 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
C06A5.1 |
182280 |
|
|
RNA interference decreased median lifespan by 39% in wild type animals, 24% in a daf-2 background and 71% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
128 |
OB_005824 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
RPL10 |
850764 |
|
|
Heterozygosity for rpl10D increased median replicative lifespan by 24%. |
17174052 |
GenAge |
129 |
OB_005835 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
RPO41 |
850507 |
|
|
Mutants exhibit reduced chronological lifespan accompanied by imbalanced mitochondrial translation, conditional inactivation of respiration, elevated production of reactive oxygen species, and increased oxidative stress. |
16782871 |
GenAge |
130 |
OB_005840 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
rps-15 |
172693 |
|
|
RNA interference in young adults reducing mRNA levels approximately two- to fivefold increased median lifespan 10-50% and maximum lifespan by about 40%. A life-extending effect was also observed in daf-16 mutants and sir-2.1 mutants but not in daf-2 mutants. TOR RNA interference further extended lifespan. |
17266679 |
GenAge |
131 |
OB_005845 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
C07A9.2 |
176368 |
|
|
RNA interference decreased median lifespan by 26% in wild type animals, 37% in a daf-2 background and 15% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
132 |
OB_005848 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Cebpb |
12608 |
|
|
Replacing the CEBPA gene by CEBPB increased lifespan by about 20%. |
15289464 |
GenAge |
133 |
OB_005856 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
rsks-1 |
176554 |
|
|
RNA interference reducing S6K (rsks-1) mRNA levels by about two-fold extended mean lifespan 13-47% and maximum lifespan by up to 60%. Deletion mutants also lived longer. A life-extending effect was also observed in daf-16 mutants and sir-2.1 mutants but not in daf-2 mutants. TOR RNA interference further extended lifespan. |
17266679 |
GenAge |
134 |
OB_005858 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
rsks-1 |
176554 |
|
|
RNAi resulted in a 22% maximum lifespan increase. In the rsks-1 (ok1255) mutant background, inhibition of ifg-1 led to a further extension of 40% in maximum lifespan. However, inhibition of let-363 (worm homologue of TOR) by RNAi in rsks-1 mutant background led to a slight shortening of MLS. In the daf-2 (e1370) mutant background, inhibition of either ifg-1 or rsks-1 further extended lifespan by 70% and 24%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan by 27% and 14%, respectively, in a daf-16 (mu86 ) background. Inhibition of either ifg-1 or rsks-1 in the clk-1(e2519) mutant background led to a further lifespan extension by 19% and 13%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan in the eat-2 background by 54% and 11%, respectively. In a sir-2.1 mutant background, ifg-1 inhibition extended lifespan by 93% and rsks-1 inhibition by 33%. |
17266680 |
GenAge |
135 |
OB_005859 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
rsr-2 |
174862 |
|
|
RNA interference decreased median lifespan by 34% in a daf-2 background and 20% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
136 |
OB_005871 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Scgdelta |
31129 |
|
|
Deletion has detrimental effects on the flight muscles of adult animals and heart function. Median lifespan was reduced 15-30%. |
17855453 |
GenAge |
137 |
OB_005873 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
SCH9 |
856612 |
|
|
Mutations increase resistance to oxidants and extend lifespan by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 are required for this life-extension. |
11292860 |
GenAge |
138 |
OB_005874 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
SCH9 |
856612 |
|
|
The deletion of SCH9, which encodes for a serine threonine kinase, triples the mean life span and increases resistance to oxidative and thermal stress. Mutations that decrease the activity of the Ras/Cyr1/PKA pathway also extend longevity and increase stress resistance by activating transcription factors Msn2/Msn4 and the mitochondrial antioxidant enzyme superoxide dismutase (Sod2). |
12855292 |
GenAge |
139 |
OB_005881 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
scl-1 |
186053 |
|
|
Required for life-extension of daf-2 and age-1 mutants. Downregulation of scl-1 reduces lifespan and stress resistance. |
12620193 |
GenAge |
140 |
OB_005884 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
SdhB |
35590 |
|
|
Mutant males are hypersensitive to oxygen and displays signs of premature ageing, including a 66% decrease in mean lifespan and a 17% decrease in maximum lifespan. |
17056719 |
GenAge |
141 |
OB_005892 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
sgk-1 |
181697 |
|
|
Deletion results in defective egg-laying, extended generation time, increased stress resistance, and life-extension. |
15068796 |
GenAge |
142 |
OB_005895 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
SGS1 |
855228 |
|
|
Mutations cause premature ageing in mother cells including a shortened lifespan, sterility, and redistribution of the Sir3 silencing protein from telomeres to the nucleolus. |
9271578 |
GenAge |
143 |
OB_005900 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Adcy5 |
224129 |
|
|
Knock out mice are resistant, have an increased median lifespan of 30% and an increased maximal lifespan of 12%. They are also protected from age-related reduced bone density and susceptibility to fractures, and reduced cardiac function. |
17662940 |
GenAge |
144 |
OB_005902 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
C11H1.3 |
181537 |
|
|
RNA interference decreased median lifespan by 10% in wild type animals, 14% in a daf-2 background and 41% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
145 |
OB_005906 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
SIP2 |
852664 |
|
|
Deletion results in reduced resistance to nutrient deprivation and a shorter lifespan accompanied by signs of accelerated ageing such as accumulation of extrachromosomal rDNA. |
10921902 |
GenAge |
146 |
OB_005911 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
sir-2.1 |
177924 |
|
|
Sir-2.1(ok434) mutants show a slight decrease in lifespan as well as sensitivity to various stresses. |
16280150 |
GenAge |
147 |
OB_005913 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Sir2 |
34708 |
|
|
Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons (10-30% median lifespan reduction) and ubiquitous silencing of the Sir2-like genes shortened lifespans. The effects were severer at 28°C than at 25°C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of lifespan in Drosophila. |
1715929 |
GenAge |
148 |
OB_005915 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Sir2 |
34708 |
|
|
Overexpression of dSir2 extends lifespan by up to 57%, whereas a decrease in dSir2 blocks the life-extending effect of caloric reduction or rpd3 mutations. |
15520384 |
GenAge |
149 |
OB_005918 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
SIR2 |
851520 |
|
|
Lack of Sir2 along with calorie restriction and/or mutations in the yeast AKT homolog, Sch9, or Ras pathways causes a dramatic chronological LS extension (6 fold). |
16286010 |
GenAge |
150 |
OB_005924 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
SIR4 |
851813 |
|
|
The short life span of a sir4 mutant (20% decrease in mean life span) is due to the simultaneous expression of a and alpha mating-type information, which indirectly causes an increase in rDNA recombination and likely increases the production of extrachromosomal rDNA circles. |
10521401 |
GenAge |
151 |
OB_005927 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Sirt2 |
42414 |
|
|
Decreased expression by RNA interference caused lethality during development. Silencing in neurons shortened mean lifespan by 20%. |
17159295 |
GenAge |
152 |
OB_005929 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Sirt6 |
50721 |
|
|
Knockout mice develop signs of premature ageing including a short lifespan. |
16439206 |
GenAge |
153 |
OB_005931 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
C14A4.9 |
174637 |
|
|
RNA interference decreased median lifespan by 14% in wild type animals and 41% in daf-2 mutants. |
18006689 |
GenAge |
154 |
OB_005933 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Sirt6 |
41254 |
|
|
Decreased expression by RNA interference caused lethality during development. Silencing in neurons shortened mean lifespan by 20%. |
17159295 |
GenAge |
155 |
OB_005935 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
skn-1 |
177343 |
|
|
RNA interference or mutations prevented the life-extension effects of dietary restriction. |
17538612 |
GenAge |
156 |
OB_005936 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
skn-1 |
177343 |
|
|
Mean lifespan extension by 5-20% after overexpression and opposite effect due to mutations. |
18358814 |
GenAge |
157 |
OB_005938 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
skr-1 |
172775 |
|
|
RNA interference in adulthood of skr-1 and skr-2 shortened the extended lifespan of daf-2(mu150) mutants by up to 44%. No effect in the lifespan of wild-type worms or in the extended lifespans of glp-1(e2141ts) or eat-2(ad1116) mutants was observed. |
17392428 |
GenAge |
158 |
OB_005939 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
skr-2 |
172773 |
|
|
RNA interference in adulthood of skr-1 and skr-2 shortened the extended lifespan of daf-2(mu150) mutants by up to 44%. No effect in the lifespan of wild-type worms or in the extended lifespans of glp-1(e2141ts) or eat-2(ad1116) mutants was observed. |
17392428 |
GenAge |
159 |
OB_005940 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Slc25a4 |
11739 |
|
|
Knockouts exhibited a shortened lifespan and increased hydrogen peroxide production and in some tissues. |
10220377 |
GenAge |
160 |
OB_005942 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
smk-1 |
179243 |
|
|
RNA interference of smk-1 completely suppressed the extended longevity of daf-2 mutations and partly the life-extension of clk-1 mutants. It only slightly shortened the lifespan of wild-type worms. |
16530049 |
GenAge |
161 |
OB_005944 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
smk-1 |
179243 |
|
|
RNAi led to a 44% decrease in median lifespan in daf-2 background and 21% decrease in lifespan in wild-type background. |
18006689 |
GenAge |
162 |
OB_005949 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
smn-1 |
172783 |
|
|
RNA interference results in a 40% decrease in median lifespan in daf-2 mutants, 13% decrease in lifespan in daf-2/daf-16 double mutants and a 26% decrease in median lifespan in a wild-type background. |
18006689 |
GenAge |
163 |
OB_005951 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
SNCA |
|
|
|
Transgenic lines overexpressing human SNCA lived about 25% longer, even in a daf-2 mutant background, and exhibited decreased pharyngeal pumping and egg-laying. |
16782295 |
GenAge |
164 |
OB_005953 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
SNF1 |
852088 |
|
|
Overexpression shortened lifespan accompanied by signs of premature ageing. |
10921902 |
GenAge |
165 |
OB_005961 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
SOD1 |
853568 |
|
|
Increasing the level of active Cu, Zn-Sod in yeast was found to require either growth in the presence of high copper, or the simultaneous overexpression of both SOD1 and CCS1 (the latter being the gene that encodes the chaperone dedicated to Cu(2+)-loading of Sod1p in vivo). Dual SOD1 + CCS1 overexpression elevated the levels of Cu,Zn-Sod activity six- to eight-fold in vegetative cultures. It also increased the optimized survival of stationary cells up to two-fold, showing this chronological lifespan is ultimately limited by oxidative stress. In contrast, several detrimental effects resulted when the SOD1 gene was overexpressed in the absence of either high copper or a simultaneous overexpression of CCS1. Both the chronological and the replicative lifespans were shortened; the cells displayed an abnormally high level of endogenous oxidative stress, resulting in a high rate of spontaneous mutation. Such harmful effects were all reversed through the overexpression of CCS1. |
15659212 |
GenAge |
166 |
OB_005964 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Sod |
39251 |
|
|
Mutant flies displayed infertility and a reduction in lifespan. |
2539600 |
GenAge |
167 |
OB_005966 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Sod |
39251 |
|
|
Overexpression of catalase and Sod1 resulted in a one-third lifespan extension, a slower rate of mortality acceleration, and a delayed loss in physical performance. |
8108730 |
GenAge |
168 |
OB_005968 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Sod |
39251 |
|
|
Cu/ZnSOD overexpression extended the mean lifespan by up to 48%. Simultaneous overexpression of catalase with Cu/ZnSOD had no added benefit, presumably due to a preexisting excess of catalase. |
9858546 |
GenAge |
169 |
OB_005973 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Sod2 |
36878 |
|
|
RNA interference results in increased oxidative stress and early-onset mortality in young adults. |
12456885 |
GenAge |
170 |
OB_005976 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
spe-26 |
177929 |
|
|
Mutation that reduced sperm production also increased mean lifespan by about 65%. |
1448167 |
GenAge |
171 |
OB_005980 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
spl-1 |
176857 |
|
|
RNA interference decreased median lifespan by 22% in wild type animals, 63% in a daf-2 background and 17% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
172 |
OB_005989 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
SSD1 |
851887 |
|
|
Overexpression increased lifespan longevity by 50%, independently of Sir2, although Sir2 further extends lifespan. |
15126388 |
GenAge |
173 |
OB_005994 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Stub1 |
56424 |
|
|
Knock-out mice exhibited a deregulation of protein quality control accompanied by a short lifespan and accelerated age-related pathophysiological features. |
18411298 |
GenAge |
174 |
OB_005998 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
sun |
44046 |
|
|
Mutations increase lifespan and resistance to oxidative stress. |
15133470 |
GenAge |
175 |
OB_006000 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Surf1 |
44498 |
|
|
Knockdown resulted in larval lethality. However, knockdown in the CNS not only bypassed the larval lethality but it resulted in an increase in maximum lifespan of about 20-30%. |
16172499 |
GenAge |
176 |
OB_006006 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
him-6 |
178201 |
|
|
Mutants have a low brood size, a shortened lifespan, and an increased amount of germ-line apoptosis. |
16181657 |
GenAge |
177 |
OB_006008 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
C25H3.6 |
173960 |
|
|
RNA interference decreased the median lifespan 42% in daf-2 long-lived mutants. |
18006689 |
GenAge |
178 |
OB_006016 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
T19B10.2 |
179551 |
|
|
RNA interference decreased median lifespan by 34% in wild type animals, 72% in a daf-2 background and 30% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
179 |
OB_006022 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
T22B11.2 |
188726 |
|
|
RNA interference decreased median lifespan by 10% in wild type animals and 26% in daf-2 mutants. |
18006689 |
GenAge |
180 |
OB_006027 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
T27F7.1 |
173863 |
|
|
RNA interference decreased median lifespan by 34% in wild type animals, 42% in a daf-2 background and 37% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
181 |
OB_006038 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
bus-8 |
180821 |
|
|
RNA interference decreased median lifespan by 58% in wild type animals, 81% in a daf-2 background and 45% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
182 |
OB_006040 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
C26B9.3 |
180804 |
|
|
RNA interference decreased median lifespan by 12% in wild type animals, 68% in a daf-2 background and 17% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
183 |
OB_006045 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
vps-36 |
179520 |
|
|
RNA interference decreased median lifespan by 27% in wild type animals, 27% in a daf-2 background and 9% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
184 |
OB_006047 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
bet-1 |
172054 |
|
|
RNA interference decreased median lifespan by 20% in daf-2 mutants. |
18006689 |
GenAge |
185 |
OB_006057 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Terf2 |
21750 |
|
|
Overexpression results in signs of premature ageing. |
16142233 |
GenAge |
186 |
OB_006059 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Tert |
21752 |
|
|
Overexpression of telomerase results in a high cancer incidence but also a modest lifespan extension accompanied by a lower incidence of some age-related degenerative diseases, in particular those related to kidney function and germline integrity. |
15688016 |
GenAge |
187 |
OB_006061 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Tert |
21752 |
|
|
9% up to 50% extension of the median lifespan, when overexpressed in mice engineered to be cancer resistant by means of enhanced expression of the tumor suppressors p53, p16, andp19ARF. |
19013273 |
GenAge |
188 |
OB_006062 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Tert |
21752 |
|
|
Telomerase reactivation in late generation TERT-ER mice extends telomeres, reduces DNA damage signalling and associated cellular checkpoint responses, allows resumption of proliferation in quiescent cultures, and eliminates degenerative phenotypes across multiple organs including testes, spleens and intestines. |
21113150 |
GenAge |
189 |
OB_006064 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
old-1 |
191737 |
|
|
Overexpression in transgenic animals increased lifespan by about 65% and increases stress resistance without altering development or fertility. |
9768365 |
GenAge |
190 |
OB_006068 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
tlf-1 |
172676 |
|
|
RNA interference decreased median lifespan by 33% in wild type animals and 49% in daf-2 mutants. |
18006689 |
GenAge |
191 |
OB_006070 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
top-1 |
266847 |
|
|
RNA interference decreased median lifespan by 19% in wild type animals and 42% in daf-2 mutants. |
18006689 |
GenAge |
192 |
OB_006072 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Top3b |
21976 |
|
|
Deletion results in a normal development but a shorter lifespan accompanied by lesions in multiple organs. |
11331780 |
GenAge |
193 |
OB_006076 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
TOR1 |
853529 |
|
|
Deletion of TOR1 substantially extended chronological life span, increasing median survival almost 3-fold (wild-type 4.5 days, tor1 null 12 days). By 21 days in culture, the vast majority of wild-type cells had died (>99.9%), whereas many tor1 null cells remained viable. Deletion of TOR1 also extended the chronological life span of the relatively short-lived strain BY4742, one of the two haploid genetic backgrounds of the widely used Yeast Knockout Collection available from Open Biosystems. Deletion of TOR1 fails to extendLS in Petite strains that are unable to respire |
17403371 |
GenAge |
194 |
OB_006082 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
C27F2.5 |
175672 |
|
|
RNA interference decreased median lifespan by 43% in wild type animals, 33% in a daf-2 background and 9% in daf-2/daf-16 double mutants. |
18006689 |
GenAge |
195 |
OB_006084 |
Saccharomyces cerevisiae |
Gene Symbol |
NCBI Gene ID |
TPK2 |
855898 |
|
|
Deletion of TPK2 in a tpk1 and tpk3 double mutant background extends lifespan by approximately 25%. |
11000115 |
GenAge |
196 |
OB_006096 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
Trx-2 |
34281 |
|
|
Mutants have a 25% reduction in maximum lifespan and exhibited lower tolerance to oxidative stress while animals carrying multiple copies of Trx-2 exhibited higher tolerance. |
17567437 |
GenAge |
197 |
OB_006098 |
Drosophila melanogaster |
Gene Symbol |
NCBI Gene ID |
TrxT |
31443 |
|
|
Overexpression in neurons increased the level of locomotor activity in aged flies and extended the mean lifespan by 15%. |
17301052 |
GenAge |
198 |
OB_006102 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
tub-1 |
174312 |
|
|
Mutation leads to life-extension dependent on daf-16. |
16054097 |
GenAge |
199 |
OB_006105 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
C29F9.1 |
175180 |
|
|
RNA interference decreased median lifespan by 35% in daf-2 mutants. |
18006689 |
GenAge |
200 |
OB_006107 |
Caenorhabditis elegans |
Gene Symbol |
NCBI Gene ID |
ubc-13 |
177073 |
|
|
RNA interference decreased median lifespan by 19% in daf-2 mutants. |
18006689 |
GenAge |