101 |
OB_000101 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CIT2 |
Saccharomyces cerevisiae |
850361 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of CIT2 has no effect on life-span. Other phenotypes: Overexpression of CIT2 has no effect on life-span [ 10224252]. CIT2 is not required for the strain specific life-span extension in petite cells. CIT2 is transcribed up to 30-fold higher in petite cells relative to grande cells [ 1986232]. |
Lifespan Observations Database (ID: 110) |
10224252 |
102 |
OB_000102 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CYT1 |
Saccharomyces cerevisiae |
854231 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
rho0 |
Absence of mitochondrial DNA. |
|
PSY316AUT rho0 cells also deleted for CYT1 are short-lived, but still have their life span extended by dietary restriction. These data demonstrate that mitochondrial respiration is not required for life span extension from dietary restriction in the PSY316AUT strain background. |
Lifespan Observations Database (ID: 1110) |
16311627 |
103 |
OB_000103 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CYT1 |
Saccharomyces cerevisiae |
854231 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
rho0 |
Absence of mitochondrial DNA. |
|
PSY316AUT rho0 cells also deleted for CYT1 are short-lived, but still have their life span extended by dietary restriction. These data demonstrate that mitochondrial respiration is not required for life span extension from dietary restriction in the PSY316AUT strain background. |
Lifespan Observations Database (ID: 1111) |
16311627 |
104 |
OB_000104 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CYT1 |
Saccharomyces cerevisiae |
854231 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.5% glucose |
|
Dietary restriction at either 0.5% or 0.05% glucose increases the replicative life span of CYT1 deletion mutants in the PSY316AUT strain background, demonstrating that mitochondrial respiration is not required for life span extension from dietary restriction. |
Lifespan Observations Database (ID: 1112) |
16311627 |
105 |
OB_000105 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CYT1 |
Saccharomyces cerevisiae |
854231 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Dietary restriction at either 0.5% or 0.05% glucose increases the replicative life span of CYT1 deletion mutants in the PSY316AUT strain background, demonstrating that mitochondrial respiration is not required for life span extension from dietary restriction. |
Lifespan Observations Database (ID: 1113) |
16311627 |
106 |
OB_000106 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
Addition of 5 mM nicotinamide shortens replicative life span in the BY4742 strain background to the same extent as deletion of SIR2. The combination of SIR2 deletion with 5 mM nicotinamide does not further shorten life span. This indicates that 5 mM nicotinamide is likely reducing life span by inhibition of SIR2. |
Lifespan Observations Database (ID: 1116) |
16311627 |
107 |
OB_000107 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Addition of 5 mM nicotinamide shortens replicative life span in the BY4742 strain background to the same extent as deletion of SIR2. The combination of SIR2 deletion with 5 mM nicotinamide does not further shorten life span. This indicates that 5 mM nicotinamide is likely reducing life span by inhibition of SIR2. |
Lifespan Observations Database (ID: 1118) |
16311627 |
108 |
OB_000108 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. |
Lifespan Observations Database (ID: 1119) |
16311627 |
109 |
OB_000109 |
2 |
Mus musculus |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Ercc2 |
Mus musculus |
13871 |
non-null recessive |
- |
unknown |
unknown |
|
|
|
Homozygous mutation of XPD results in an extreme shortening of life-span (mean life-span = 7 months) relative to wild type (mean life-span > 24 months). Other phenotypes: The shortened life span of the mutant mouse is accompanied by symptoms of premature aging including including osteoporosis, early graying, cachexia, and infertility [ 11950998]. Mouse model for the brittle hair disorder trichothiodystrophy (TTD). Phenotypes include brittle hair, UV sensitivity, and developmental defects [ 9651581]. |
Lifespan Observations Database (ID: 111) |
11950998 |
110 |
OB_000110 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. |
Lifespan Observations Database (ID: 1120) |
16311627 |
111 |
OB_000111 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. |
Lifespan Observations Database (ID: 1121) |
16311627 |
112 |
OB_000112 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Addition of 5 mM nicotinamide has no effect on replicative life span in BY4742 sir2 fob1 double mutant cells. Dietary restriction is still able to increase life span of sir2 fob1 double mutant cells treated with 5 mM nicotinamide. These data demonstrate that SIR2 and other nicotinamide-sensitive sirtuins are not required for life span extension from dietary restriction in the BY4742 strain background. |
Lifespan Observations Database (ID: 1122) |
16311627 |
113 |
OB_000113 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. |
Lifespan Observations Database (ID: 1123) |
16741098 |
114 |
OB_000114 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.5% glucose |
|
Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. |
Lifespan Observations Database (ID: 1124) |
16741098 |
115 |
OB_000115 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. |
Lifespan Observations Database (ID: 1125) |
16741098 |
116 |
OB_000116 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.005% glucose |
|
Dietary restriction at 0.5%, 0.05%, or 0.005% glucose significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from dietary restriction. |
Lifespan Observations Database (ID: 1126) |
16741098 |
117 |
OB_000117 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of HXK2 significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from deletion of HXK2. Deletion of HXK2 is proposed as a genetic mimic of dietary restriction [ 11000115]. |
Lifespan Observations Database (ID: 1127) |
16741098 |
118 |
OB_000118 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of HXK2 significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from deletion of HXK2. Deletion of HXK2 is proposed as a genetic mimic of dietary restriction [ 11000115]. |
Lifespan Observations Database (ID: 1128) |
16741098 |
119 |
OB_000119 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of HXK2 significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from deletion of HXK2. Deletion of HXK2 is proposed as a genetic mimic of dietary restriction [ 11000115]. |
Lifespan Observations Database (ID: 1129) |
16741098 |
120 |
OB_000120 |
2 |
Mus musculus |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
GHR |
Mus musculus |
|
deletion / null |
- |
unknown |
unknown |
|
|
|
Mice homozygous for disruption of GHR/BP have a life-span that is 40-50% longer than wild type or heterozygous mice. Other phenotypes: The GHR/BP knockout mouse is a model for the rare human disease Laron syndrome [ 9371826]. Serum levels of GH are elevated in mutant mice [ 9371826]. Mutant mice are smaller than wild type mice. IGF-I and IGFBP-3 levels are also reduc |
Lifespan Observations Database (ID: 112) |
10875265 |
121 |
OB_000121 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of HST1, HST2, or HST4 had no effect on replicative life span of BY4742 mother cells. Deletion of either SIR2 or HST3 shortened life span. |
Lifespan Observations Database (ID: 1133) |
17129213 |
122 |
OB_000122 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of HST1, HST2, or HST4 had no effect on replicative life span of BY4742 mother cells. Deletion of either SIR2 or HST3 shortened life span. |
Lifespan Observations Database (ID: 1134) |
17129213 |
123 |
OB_000123 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of HST1, HST2, or HST4 had no effect on replicative life span of BY4742 mother cells. Deletion of either SIR2 or HST3 shortened life span. |
Lifespan Observations Database (ID: 1135) |
17129213 |
124 |
OB_000124 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of HST1, HST2, or HST4 had no effect on replicative life span of BY4742 mother cells. Deletion of either SIR2 or HST3 shortened life span. |
Lifespan Observations Database (ID: 1136) |
17129213 |
125 |
OB_000125 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of HST1, HST2, or HST4 had no effect on replicative life span of BY4742 mother cells. Deletion of either SIR2 or HST3 shortened life span. |
Lifespan Observations Database (ID: 1137) |
17129213 |
126 |
OB_000126 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of HST2 had no effect on replicative life span of W303AR5 mother cells. |
Lifespan Observations Database (ID: 1138) |
17129213 |
127 |
OB_000127 |
2 |
Homo sapiens |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Mot-2 |
Homo sapiens |
|
over-expression |
- |
unknown |
unknown |
|
|
|
Transfection of normal human fiboblasts with human or murine Mot-2 overexpression vectors led to an increase in the number of population doublings the cells could sustain before senescing (percent increase varying from 32% to 60%, depending on the exact construct used). Other phenotypes: Mot-2 is an hsp70 family member found to be differentially distributed and/or translated in normal vs. transformed cells [ 8454632]. Mot-2 overexpressing cells exhibited a reduction in p53 transcriptional activation, as measured by expression from vectors containing either luciferase or beta-galactosidase driven by p53 binding sites [ 10838077]. Furthermore, the transfected cells retained a youthful morphology longer than the control cells, and there was a delay in appearance of senescence associated beta-galactosidase activity [ 10838077]. |
Lifespan Observations Database (ID: 113) |
8454632 |
128 |
OB_000128 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1142) |
17129213 |
129 |
OB_000129 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1143) |
17129213 |
130 |
OB_000130 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1144) |
17129213 |
131 |
OB_000131 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1145) |
17129213 |
132 |
OB_000132 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1146) |
17129213 |
133 |
OB_000133 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1147) |
17129213 |
134 |
OB_000134 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
25 |
millimolar |
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1148) |
17129213 |
135 |
OB_000135 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
25 |
millimolar |
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1149) |
17129213 |
136 |
OB_000136 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hsp-6 |
Caenorhabditis elegans |
178873 |
over-expression |
- |
unknown |
unknown |
|
|
|
Overexpression of hsp70F from a muscle-specific promoter increased life-span (mean increase: 43%, maximum increase: 45%) relative to animals expressing GFP from the same promoter. Other phenotypes: C. elegans hsp70F is the homolog of mammalian mortalin (mot-2/mthsp70/Grp75) [ 2766926], which has been shown to be capable of increasing the proliferative potential of normal fibroblasts when overexpressed [ 10838077]. The hsp70F transgene was integrated into the genome, not an extrachromosomal array. It was confirmed immunohistochemically to be expressed predominantly in muscle [ 11959102]. |
Lifespan Observations Database (ID: 114) |
11959102 |
137 |
OB_000137 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1150) |
17129213 |
138 |
OB_000138 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1151) |
17129213 |
139 |
OB_000139 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1152) |
17129213 |
140 |
OB_000140 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1153) |
17129213 |
141 |
OB_000141 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
25 |
millimolar |
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1154) |
17129213 |
142 |
OB_000142 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1155) |
17129213 |
143 |
OB_000143 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.5% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1156) |
17129213 |
144 |
OB_000144 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1157) |
17129213 |
145 |
OB_000145 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.005% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1158) |
17129213 |
146 |
OB_000146 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1159) |
17129213 |
147 |
OB_000147 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
clk-1 |
Caenorhabditis elegans |
175729 |
non-null recessive |
- |
unknown |
unknown |
daf-2 |
Caenorhabditis elegans |
175410 |
non-null recessive |
- |
unknown |
unknown |
|
|
|
Mutation of both clk-1 and daf-2 results in a nearly 5-fold (500%) increase in life-span. Other phenotypes: Overexpression of clk-1 increases mitochondrial activity and shortens life-span [ 10202142]. Loss of function mutation increases adult life-span by 30% [ 8638122]. Mutations in clk-1 are highly pleiotropic resulting in an average lengthening of embryonic development, post-embryonic development, and adult rhythmic behaviors such as defecation, swimming, and pharyngeal pumping [ 7768437]. |
Lifespan Observations Database (ID: 115) |
8638122 |
148 |
OB_000148 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1160) |
17129213 |
149 |
OB_000149 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1161) |
17129213 |
150 |
OB_000150 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1162) |
17129213 |
151 |
OB_000151 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1163) |
17129213 |
152 |
OB_000152 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1164) |
17129213 |
153 |
OB_000153 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1165) |
17129213 |
154 |
OB_000154 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1166) |
17129213 |
155 |
OB_000155 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1167) |
17129213 |
156 |
OB_000156 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1168) |
17129213 |
157 |
OB_000157 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1169) |
17129213 |
158 |
OB_000158 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
clk-1 |
Caenorhabditis elegans |
175729 |
non-null recessive |
- |
unknown |
unknown |
|
|
|
Loss of function mutation increases adult life-span by 30%. Other phenotypes: Mutation of both clk-1 and daf-2 results in a nearly 5-fold (500%) increase in life-span [ 8638122]. Overexpression of clk-1 increases mitochondrial activity and shortens life-span [ 10202142]. Mutations in clk-1 are highly pleiotropic resulting in an average lengthening of embryonic development, post-embryonic development, and adult rhythmic behaviors such as defecation, swimming, and pharyngeal pumping [ 7768437]. |
Lifespan Observations Database (ID: 116) |
8638122 |
159 |
OB_000159 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.5% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1170) |
17129213 |
160 |
OB_000160 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1171) |
17129213 |
161 |
OB_000161 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.005% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1172) |
17129213 |
162 |
OB_000162 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1173) |
17129213 |
163 |
OB_000163 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1174) |
17129213 |
164 |
OB_000164 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1175) |
17129213 |
165 |
OB_000165 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
Compound Name |
Quantity |
Quantity Unit |
Nicotinamide |
5 |
millimolar |
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1176) |
17129213 |
166 |
OB_000166 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1177) |
17129213 |
167 |
OB_000167 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
hst3 |
Saccharomyces cerevisiae |
854190 |
deletion / null |
- |
unknown |
unknown |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1178) |
17129213 |
168 |
OB_000168 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hst4 |
Saccharomyces cerevisiae |
851772 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Data from Table 1: Replicative lifespans of different sirtuin mutants in response to calorie restriction or nicotinamide. |
Lifespan Observations Database (ID: 1179) |
17129213 |
169 |
OB_000169 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HAP4 |
Saccharomyces cerevisiae |
853751 |
over-expression |
- |
unknown |
unknown |
|
|
|
Overexpression of HAP4 from the ADH1 promoter extends life-span approximately 40% under growth conditions favoring fermentation (2% glucose). Other phenotypes: Overexpression of HAP4 combined with calorie restriction (CR) fails to further extend life-span. Like CR, life-span extension by HAP4 requires SIR2. HAP4 overexpressing cells demonstrate a transcriptional response resembling cells undergoing diauxic shift, consume more oxygen than wild type cells, and show increased Sir2p-dependent transcriptional silencing at telomeres and rDNA [ 12124627]. |
Lifespan Observations Database (ID: 117) |
12124627 |
170 |
OB_000170 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
AFG3 |
Saccharomyces cerevisiae |
856737 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1180) |
18340043 |
171 |
OB_000171 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
IDH2 |
Saccharomyces cerevisiae |
854303 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1181) |
18340043 |
172 |
OB_000172 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
INP53 |
Saccharomyces cerevisiae |
854276 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1182) |
18340043 |
173 |
OB_000173 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
RPL19A |
Saccharomyces cerevisiae |
852379 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1183) |
18340043 |
174 |
OB_000174 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
RPL6B |
Saccharomyces cerevisiae |
851169 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1184) |
18340043 |
175 |
OB_000175 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SPT4 |
Saccharomyces cerevisiae |
852955 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1185) |
18340043 |
176 |
OB_000176 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TIF1 |
Saccharomyces cerevisiae |
853933 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1186) |
18340043 |
177 |
OB_000177 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TIF2 |
Saccharomyces cerevisiae |
853303 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1187) |
18340043 |
178 |
OB_000178 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TIF4631 |
Saccharomyces cerevisiae |
853071 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1188) |
18340043 |
179 |
OB_000179 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1189) |
18340043 |
180 |
OB_000180 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CYT1 |
Saccharomyces cerevisiae |
854231 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of CYT1 has no effect on life-span, but prevents life-span extension by overexpression of HAP4. Other phenotypes: CYT1 is required for respiration in yeast. |
Lifespan Observations Database (ID: 118) |
12124627 |
181 |
OB_000181 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ADH1 |
Saccharomyces cerevisiae |
854068 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1190) |
18340043 |
182 |
OB_000182 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ALG12 |
Saccharomyces cerevisiae |
855764 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1191) |
18340043 |
183 |
OB_000183 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
DBP3 |
Saccharomyces cerevisiae |
852802 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1192) |
18340043 |
184 |
OB_000184 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HSE1 |
Saccharomyces cerevisiae |
856387 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1193) |
18340043 |
185 |
OB_000185 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
IDH1 |
Saccharomyces cerevisiae |
855691 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1194) |
18340043 |
186 |
OB_000186 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
INP51 |
Saccharomyces cerevisiae |
854815 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1195) |
18340043 |
187 |
OB_000187 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PKH2 |
Saccharomyces cerevisiae |
854053 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1196) |
18340043 |
188 |
OB_000188 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PMR1 |
Saccharomyces cerevisiae |
852709 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1197) |
18340043 |
189 |
OB_000189 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SAM1 |
Saccharomyces cerevisiae |
850877 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1198) |
18340043 |
190 |
OB_000190 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1199) |
18340043 |
191 |
OB_000191 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SOD1 |
Saccharomyces cerevisiae |
853568 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of Cu-Zn superoxide dismutase decreases replicative life-span by approximately 40%. Other phenotypes: The magnitude of the decrease in life-span does not appear to be dependent on oxygen concentration in the atmosphere [ 12020810]. Deletion of SOD1 shortens chronological life-span as well as replicative life span [ 10222047]. Overexpression of SOD1 has no effect on replicative life-span [ 10224252]. |
Lifespan Observations Database (ID: 119) |
12020810 |
192 |
OB_000192 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB2 |
Saccharomyces cerevisiae |
853146 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of both PHB1 and PHB2 results in a life span that is approximately 40% shorter than wild type. Other phenotypes: Deletion of PHB1 results in approximately 20% shorter lifespan. Phenotypic changes characteristic of aging cells may suggest that PHB1/PHB2 mutants undergo premature aging, not simply reduction in viability. These changes include lengthening of cell cycle and characteristic morphological changes [ 9259555]. No reduction in stress resistance or bulk growth rate. A strong defect in mitochondrial potential was detected in the phb1 phb2 double mutant., and a slight defect in the phb1 single mutant [ 9259555]. |
Lifespan Observations Database (ID: 11) |
9259555 |
193 |
OB_000193 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIS2 |
Saccharomyces cerevisiae |
853946 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1200) |
18340043 |
194 |
OB_000194 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TIS11 |
Saccharomyces cerevisiae |
850827 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1201) |
18340043 |
195 |
OB_000195 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YGR130C |
Saccharomyces cerevisiae |
853031 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1202) |
18340043 |
196 |
OB_000196 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YPT6 |
Saccharomyces cerevisiae |
850966 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1203) |
18340043 |
197 |
OB_000197 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YPT6 |
Saccharomyces cerevisiae |
850966 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1204) |
18340043 |
198 |
OB_000198 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YGR130C |
Saccharomyces cerevisiae |
853031 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1205) |
18340043 |
199 |
OB_000199 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TIS11 |
Saccharomyces cerevisiae |
850827 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1206) |
18340043 |
200 |
OB_000200 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIS2 |
Saccharomyces cerevisiae |
853946 |
deletion / null |
- |
unknown |
unknown |
|
|
|
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Lifespan Observations Database (ID: 1207) |
18340043 |