Gene: TOPORS - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | TOPORS | ||||||||||||||||
NCBI Gene ID | : | 10210 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | E3 ubiquitin-protein ligase Topors | LUN | p53-BINDING PROTEIN 3 | P53BP3 | retinitis pigmentosa 31 (autosomal dominant) | RP11-205M20.5 | RP31 | SUMO1-protein E3 ligase Topors | topoisomerase I binding, arginine/serine-rich | topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase | TOPOISOMERASE I-BINDING ARGININE/SERINE-RICH PROTEIN | topoisomerase I-binding RING finger protein | TOPORS | TP53BPL | tumor suppressor p53-binding protein 3 Source: GPSDB |
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Gene Homologs | : | si:ch211-145b13.4 (Danio rerio) | TOPORS (Bos taurus) | TOPORS (Canis lupus familiaris) | TOPORS (Gallus gallus) | TOPORS (Homo sapiens) | TOPORS (Macaca mulatta) | Topors (Mus musculus) | TOPORS (Pan troglodytes) | Topors (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000006 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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E3 ubiquitin-protein ligase Topors | Homo sapiens | Q9NS56 (UniProtKB/Swiss-Prot) | TOPRS_HUMAN (UniProtKB/Swiss-Prot) | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_009799 | Homo sapiens |
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TOPORS is an E3 ubiquitin-protein ligase and an E3 SUMO1-protein ligase, which acts as a tumor suppressor and is involved in cell growth, cell proliferation and apoptosis, regulating p53 stability through ubiquitin-dependent degradation [2182]. Homozygote knockout mice exhibited a significantly reduced lifespan, while a slight reduction in lifespan was observed for the heterozygote knockout. Several mice showed some signs of premature aging, including kyphosis, and a high incidence of multiple forms of cancer tumors [2183]. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008696 | 2 | The HomoloGene homology group 4237 contains 2 genes with experimental evidence for ageing relevance (TOPORS - Homo sapiens | Topors - Mus musculus) and 7 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 4237 |
Sequences
TOPRS_HUMAN | Q9NS56 | E3 ubiquitin-protein ligase Topors (Homo sapiens) from UniProtKB/Swiss-Prot Length: 1045 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 TOPRS_HUMAN 1 MGSQPPLGSPLSREEGEAPPPAPASEGRRRSRRVRLRGSCRHRPSFLGCRELAASAPARPAPASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFVTPDRRFRYRTTLTRERNASVYSPSGPVNRRTTTPPDSGVLFEGLGISTRPRDVEIPQFMRQIAVRRPTTADERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDINVATVSQAPWDDETPGPSYSSSEQVHVTMSSLLNTSDSSDEELVTGGATSQIQGVQTNDDLNNDSDDSSDNCVIVGFVKPLAERTPELVELSSDSEDLGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLGKDEQINKGHCDSSTRIKSKKEEKRSTSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSSDSRSQSRSGHDQKNHRKHHGKKRMKSKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRVQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSRTASTGTDRVRNEKPGGKRKYKTRHLEGTNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNESDTFSDSRSSDRETKHKRRKRKTRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDNASRSPVVITIDSDSDKDSEVKEDTECDNSGPQDPLQNEFLAPSLEPFETKDVVTIEAEFGVLDKECDIATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQPSNIVSLQTEPSRQLPSPRTSLMSVCLGRDCDMS 1045
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Lin L, Ozaki T, Takada Y, Kageyama H, Nakamura Y, Hata A, Zhang JH, Simonds WF, Nakagawara A, Koseki H:
topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage.
Oncogene. 2005; 24: 3385-96.
PubMed (ID: 15735665), doi:10.1038/sj.onc.1208554
MeSH Terms: Apoptosis/genetics; Carrier Proteins/genetics; Carrier Proteins/pharmacology; DNA Damage; DNA-Binding Proteins/genetics; DNA-Binding Proteins/pharmacology; Gene Expression Regulation; Neoplasm Proteins/genetics; Neoplasm Proteins/pharmacology; Nuclear Proteins/genetics; Nuclear Proteins/pharmacology; Transcription Factors/genetics; Transcription Factors/pharmacology; Tumor Suppressor Protein p53/biosynthesis; Tumor Suppressor Protein p53/pharmacology - Marshall H, Bhaumik M, Aviv H, Moore D, Yao M, Dutta J, Rahim H, Gounder M, Ganesan S, Saleem A, Rubin E:
Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.
BMC Mol Biol. 2010; 11: 31.
PubMed (ID: 20429939), PubMed Central (ID: PMC2873312), doi:10.1186/1471-2199-11-31
MeSH Terms: Neoplasms/genetics; Tumor Suppressor Proteins/metabolism; Ubiquitin-Protein Ligases/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot