Gene: Slc9a3r1 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Slc9a3r1 | ||||||||||||
NCBI Gene ID | : | 26941 | ||||||||||||
Species | : | Mus musculus | ||||||||||||
Gene Synonyms | : | EBP-50 | EBP50 | ezrin-radixin-moesin-binding phosphoprotein 50 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | NHE-RF | Nherf | NHERF-1 | NHERF1 | Nherf1 | regulatory cofactor of Na(+)/H(+) exchanger | RP23-342L24.4 | Slc9a3r1 | sodium-hydrogen exchanger regulatory factor | sodium-hydrogen exchanger regulatory factor 1 | solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | solute carrier family 9 isoform A3 regulatory factor 1 Source: GPSDB |
||||||||||||
Gene Homologs | : | LOC100329719 (Danio rerio) | SLC9A3R1 (Bos taurus) | SLC9A3R1 (Canis lupus familiaris) | slc9a3r1 (Danio rerio) | SLC9A3R1 (Gallus gallus) | SLC9A3R1 (Homo sapiens) | SLC9A3R1 (Macaca mulatta) | Slc9a3r1 (Mus musculus) | SLC9A3R1 (Pan troglodytes) | Slc9a3r1 (Rattus norvegicus) | tag-60 (Caenorhabditis elegans) | ||||||||||||
Ageing Relevance Analysis | : |
|
||||||||||||
Ageing Factor Stable ID | : | AF_000012 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | Mus musculus | P70441 (UniProtKB/Swiss-Prot) | NHRF1_MOUSE (UniProtKB/Swiss-Prot) | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling (By similarity). May participate in HTR4 targeting to microvilli. Involved in the regulation of phosphate reabsorption in the renal proximal tubules. | View |
Solute carrier family 9 (Sodium/hydrogen exchanger), isoform 3 regulator 1 | Mus musculus | Q3TG37 (UniProtKB/TrEMBL) | Q3TG37_MOUSE (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009433 | 1 | The HomoloGene homology group 3137 contains 1 gene with experimental evidence for ageing relevance (mpz-2 - Caenorhabditis elegans) and 10 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 3137 |
Sequences
NHRF1_MOUSE | P70441 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Mus musculus) from UniProtKB/Swiss-Prot Length: 355 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 NHRF1_MOUSE 1 MSADAAAGEPLPRLCCLEKGPNGYGFHLHGEKGKVGQFIRLVEPGSPAEKSGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDERLKKLGVSIREELLRPQEKSEQAEPPAAADTHEAGDQNEAEKSHLRELRPRLCTMKKGPNGYGFNLHSDKSKPGQFIRAVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIKGGGDEAKLLVVDKETDEFFKKCKVIPSQEHLDGPLPEPFSNGEIQKESSREALVEPASESPRPALARSASSDTSEELNSQDSPKRQVSTEPSSTSSSSSDPILDLNISLAVAKERAHQKRSSKRAPQMDWSKKNELFSNL 355
Q3TG37_MOUSE | Q3TG37 | Solute carrier family 9 (Sodium/hydrogen exchanger), isoform 3 regulator 1 (Mus musculus) from UniProtKB/TrEMBL Length: 355 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 Q3TG37_MOUSE 1 MSADAAAGEPLPRLCCLEKGPNGYGFHLHGEKGKVGQFIRLVEPGSPAEKSGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDERLKKLGVSIREELLRPQEKSEQAEPPAAADTHEAGDQNEAEKSHLRELRPRLCTMKKGPNGYGFNLHSDKSKPGQFIRAVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIKGGGDEAKLLVVDKETDEFFKKCKVIPSQEHLDGPLPEPFSNGEIQKESSREALVEPASESPRPALARSASSDTSEELNSQDSPKRQVSTEPSSTSSSSSDPILDLNISLAVAKERAHQKRSSKRAPQMDWSKKNELFSNL 355
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL