Gene: Irs2 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Irs2 |
NCBI Gene ID |
: |
384783 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
4PS | insulin receptor substrate 2 | Irs-2 | Irs2
Source: GPSDB |
Gene Homologs |
: |
IRS2 (Canis lupus familiaris) | IRS2 (Gallus gallus) | IRS2 (Homo sapiens) | IRS2 (Macaca mulatta) | Irs2 (Mus musculus) | IRS2 (Pan troglodytes) | Irs2 (Rattus norvegicus) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
increased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_000025 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005446 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Irs2 |
384783 |
|
|
Irs2 brain-specific knockout mice were overweight, hyperinsulinemic, glucose intolerant, yet more active and lived up to 18% longer. |
17641201 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_005447 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Irs2 |
Mus musculus |
384783 |
Knockout |
- |
wildtype |
yes |
|
|
|
increased |
18.00% |
|
|
|
unknown |
|
|
|
Irs2 brain-specific knockout mice were overweight, hyperinsulinemic, glucose intolerant, yet more active and lived up to 18% longer. |
Taguchi et al. |
2007 |
17641201 |
doi:10.1126/science.1142179 |
GenAge |
2 |
OB_002800 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Irs2 |
Mus musculus |
384783 |
loss of function |
- |
unknown |
unknown |
|
|
|
increased |
17.24% |
925 |
789 |
days |
median |
21 |
℃ |
|
Irs2 brain-specific knockout mice lived up to 18% longer. Other phenotypes: Also were overweight, hyperinsulinemic, glucose intolerant, yet more active. |
Taguchi et al. |
2007 |
17641201 |
doi:10.1126/science.1142179 |
Lifespan Observations Database (ID: 4090) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008511 |
|
2 |
The HomoloGene homology group 2778 contains 2 genes with experimental evidence for ageing relevance (IRS2 - Homo sapiens | Irs2 - Mus musculus) and 5 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 2778 |
Sequences
Sources
Ageing-related Data Sources
Additional Data Sources