Gene: Prkag2 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Prkag2 | ||||||||||||
NCBI Gene ID | : | 108099 | ||||||||||||
Species | : | Mus musculus | ||||||||||||
Gene Synonyms | : | 5'-AMP-activated protein kinase subunit gamma-2 | 5-AMP-activated protein kinase, gamma-2 subunit | AAKG | AAKG2 | AMPK gamma-2 chain | AMPK gamma2 | AMPK subunit gamma-2 | H91620p | Prkag2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | WPWS Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP001446 (Anopheles gambiae) | AGOS_AFL015C (Eremothecium gossypii) | KLLA0F10769g (Kluyveromyces lactis) | MGG_04005 (Magnaporthe oryzae) | NCU01471 (Neurospora crassa) | Os04g0401300 (Oryza sativa) | PRKAG2 (Canis lupus familiaris) | PRKAG2 (Gallus gallus) | PRKAG2 (Homo sapiens) | Prkag2 (Mus musculus) | PRKAG2 (Pan troglodytes) | Prkag2 (Rattus norvegicus) | SNF4 (Saccharomyces cerevisiae) | SNF4Agamma (Drosophila melanogaster) | SPAC1F12.01c (Schizosaccharomyces pombe) | zgc:153329 (Danio rerio) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000033 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
5'-AMP-activated protein kinase subunit gamma-2 | Mus musculus | Q91WG5 (UniProtKB/Swiss-Prot) | AAKG2_MOUSE (UniProtKB/Swiss-Prot) | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. | View |
Putative uncharacterized protein | Mus musculus | Q3TMN8 (UniProtKB/TrEMBL) | Q3TMN8_MOUSE (UniProtKB/TrEMBL) | View | |
5'-AMP-activated protein kinase subunit gamma-2 | Mus musculus | Q8BIQ9 (UniProtKB/TrEMBL) | Q8BIQ9_MOUSE (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008570 | 2 | The HomoloGene homology group 90952 contains 2 genes with experimental evidence for ageing relevance (SNF4 - Saccharomyces cerevisiae | SNF4Agamma - Drosophila melanogaster) and 14 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 90952 |
Sequences
AAKG2_MOUSE | Q91WG5 | 5'-AMP-activated protein kinase subunit gamma-2 (Mus musculus) from UniProtKB/Swiss-Prot Length: 566 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 AAKG2_MOUSE 1 MGSAAMDTKKKKEVSSPGGSSGKKNPSLKRRSLRVHIPDLSSFAMPLLDGDVENSEKHSSRKVDSPFSSGSPSRGLFSRGPQPRPSSPVSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPSTSPGGIRFFSRSRKTSSVSSSPSTPTQVTKQHPFPLESYKQEPERPESRIYASSSPPDTGQRFCLAFQSPARPPLASPTYHAPLRTAVLAAAPGPAEAGMLEKLEFQEEEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCSKLETLETIVDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAGAKQKETETE 566
Q3TMN8_MOUSE | Q3TMN8 | Putative uncharacterized protein (Mus musculus) from UniProtKB/TrEMBL Length: 326 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 Q3TMN8_MOUSE 1 MLEKLEFQEEEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCSKLETLETIVDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAGAKQKETETE 326
Q8BIQ9_MOUSE | Q8BIQ9 | 5'-AMP-activated protein kinase subunit gamma-2 (Mus musculus) from UniProtKB/TrEMBL Length: 443 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 Q8BIQ9_MOUSE 1 MKRFGSLRGTKKPKDQNRSTQRRQSEPHGLFASSVSSSPSTPTQVTKQHPFPLESYKQEPERPESRIYASSSPPDTGQRFCLAFQSPARPPLASPTYHAPLRTAVLAAAPGPAEAGMLEKLEFQEEAEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCSKLETLETIVDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAGAKQKETETE 443
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL