Gene: htr1b - Mus musculus(see also ageing factor AF_008907 *)
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | htr1b | ||||||||||||||||
NCBI Gene ID | : | 15551 * | ||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||
Gene Synonyms | : | 5-HT-1B | 5-HT1B receptor | 5-HT<1B> receptor | 5-hydroxytryptamine (serotonin) receptor 1B | 5-hydroxytryptamine receptor 1B | 5ht1b | 5HT1B receptor | Htr1b | serotonin receptor 1B Source: GPSDB |
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Gene Homologs | : | 5-HT7 (Drosophila melanogaster) | GPR5HT7 (Anopheles gambiae) | GPRNNA20 (Anopheles gambiae) | HTR1B (Bos taurus) | HTR1B (Canis lupus familiaris) | htr1b (Danio rerio) | HTR1B (Gallus gallus) | HTR1B (Homo sapiens) | HTR1B (Macaca mulatta) | htr1b (Mus musculus) | HTR1B (Pan troglodytes) | Htr1b (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000042 | ||||||||||||||||
Download | : | XML |
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AgeFactDB contains further genes associated with gene symbol htr1b and the species Mus musculus: AF_008907
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
5-hydroxytryptamine receptor 1B | Mus musculus | P28334 (UniProtKB/Swiss-Prot) | 5HT1B_MOUSE (UniProtKB/Swiss-Prot) | This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. | View |
5-hydroxytryptamine (Serotonin) receptor 1B | Mus musculus | Q0VES5 (UniProtKB/TrEMBL) | Q0VES5_MOUSE (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_005394 | Mus musculus |
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Knockout mice displayed a decreased lifespan and early age-related motor decline. | 17420766 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_005395 | Mus musculus |
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decreased | unknown | Knockout mice displayed a decreased lifespan and early age-related motor decline. | Sibille et al. | 2007 | 17420766 | doi:10.1038/sj.mp.4001990 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008921 | 1 | The HomoloGene homology group 669 contains 1 gene with experimental evidence for ageing relevance (Htr1b - Mus musculus) and 11 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 669 |
Sequences
5HT1B_MOUSE | P28334 | 5-hydroxytryptamine receptor 1B (Mus musculus) from UniProtKB/Swiss-Prot Length: 386 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 5HT1B_MOUSE 1 MEEQGIQCAPPPPAASQTGVPLTNLSHNCSADGYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVEYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEMLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRAPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG 386
Q0VES5_MOUSE | Q0VES5 | 5-hydroxytryptamine (Serotonin) receptor 1B (Mus musculus) from UniProtKB/TrEMBL Length: 386 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 Q0VES5_MOUSE 1 MEEQGIQCAPPPPAASQTGVPLTNLSHNCSADGYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVEYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEMLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRAPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCAG 386
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Sibille E, Su J, Leman S, Le Guisquet AM, Ibarguen-Vargas Y, Joeyen-Waldorf J, Glorioso C, Tseng GC, Pezzone M, Hen R, Belzung C:
Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity.
Mol Psychiatry. 2007; 12: 1042-56, 975.
PubMed (ID: 17420766), PubMed Central (ID: PMC2515886), doi:10.1038/sj.mp.4001990
MeSH Terms: Aging/physiology; Gene Expression Regulation/genetics; Gene Expression/genetics; Motor Activity/genetics; Receptor, Serotonin, 5-HT1B/deficiency
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/TrEMBL
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot