Gene: YWHAZ - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | YWHAZ | ||||||||||||||||
NCBI Gene ID | : | 7534 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | 14-3-3 delta | 14-3-3 protein zeta/delta | 14-3-3 protein/cytosolic phospholipase A2 | 14-3-3 zeta | 14-3-3-ZETA | 14-3-3-zeta | BRAIN PROTEIN 14-3-3, ZETA ISOFORM | KCIP-1 | phospholipase A2 | protein kinase C inhibitor protein 1 | protein kinase C inhibitor protein-1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide | TYROSINE 3-MONOOXYGENASE/TRYPTOPHAN 5-MONOOXYGENASE ACTIVATION PROTEIN, ZETA ISOFORM | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide | YWHAD | YWHAZ Source: GPSDB |
||||||||||||||||
Gene Homologs | : | 14-3-3zeta (Drosophila melanogaster) | AgaP_AGAP007643 (Anopheles gambiae) | ftt-2 (Caenorhabditis elegans) | LOC100855903 (Canis lupus familiaris) | par-5 (Caenorhabditis elegans) | ywhaqa (Danio rerio) | ywhaqb (Danio rerio) | YWHAZ (Gallus gallus) | YWHAZ (Homo sapiens) | YWHAZ (Macaca mulatta) | Ywhaz (Mus musculus) | YWHAZ (Pan troglodytes) | Ywhaz (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
|
||||||||||||||||
Ageing Factor Stable ID | : | AF_000049 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
14-3-3 protein zeta/delta | Homo sapiens | P63104 (UniProtKB/Swiss-Prot) | 1433Z_HUMAN (UniProtKB/Swiss-Prot) | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. | View |
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide | Homo sapiens | D0PNI1 (UniProtKB/TrEMBL) | D0PNI1_HUMAN (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009820 | Homo sapiens |
|
YWHAZ is an adapter protein implicated in several signal transduction pathways [0997]. Although YWHAZ has not been directly related to ageing, because it interacts with so many proteins, including many associated with ageing such as the INS/IGF1 pathway [0996], it is possible that YWHAZ itself plays some role in human ageing. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008896 | 3 | The HomoloGene homology group 56528 contains 3 genes with experimental evidence for ageing relevance (YWHAZ - Homo sapiens | ftt-2 - Caenorhabditis elegans | par-5 - Caenorhabditis elegans) and 10 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 56528 |
Sequences
1433Z_HUMAN | P63104 | 14-3-3 protein zeta/delta (Homo sapiens) from UniProtKB/Swiss-Prot Length: 245 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 1433Z_HUMAN 1 MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN 245
D0PNI1_HUMAN | D0PNI1 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide (Homo sapiens) from UniProtKB/TrEMBL Length: 245 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 D0PNI1_HUMAN 1 MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN 245
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T:
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
J Biol Chem. 1997; 272: 25267-74.
PubMed (ID: 9312143)
MeSH Terms: Insulin/pharmacology; Myocardium/metabolism; Phosphoproteins/chemistry; Phosphoproteins/metabolism; Phosphotyrosine; Proteins/chemistry; Proteins/metabolism; Receptor, Insulin/metabolism; Tyrosine 3-Monooxygenase - Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ, Cantley LC:
The structural basis for 14-3-3:phosphopeptide binding specificity.
Cell. 1997; 91: 961-71.
PubMed (ID: 9428519)
MeSH Terms: Enzyme Inhibitors/metabolism; Phosphopeptides/metabolism; Phosphoserine/metabolism; Proteins/metabolism; Tyrosine 3-Monooxygenase - Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L:
Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt.
Proc Natl Acad Sci USA. 2004; 101: 15370-5.
PubMed (ID: 15492215), PubMed Central (ID: PMC524456), doi:10.1073/pnas.0406499101
MeSH Terms: 14-3-3 Proteins/metabolism; Cytoskeletal Proteins/metabolism; Protein-Serine-Threonine Kinases/metabolism; Proteome; Proto-Oncogene Proteins/metabolism; Trans-Activators/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL