Gene: LAG2 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | LAG2 | ||||||||||||||||||||
NCBI Gene ID | : | 854133 | ||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||
Gene Synonyms | : | ECM36 | LAG2 | Lag2p | YOL025W Source: GPSDB |
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Gene Homologs | : | |||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000071 | ||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_005483 | Saccharomyces cerevisiae |
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increased | 54.00% | maximum | Overexpression extended mean and maximum lifespan by 36% and 54%, respectively. | Childress et al. | 1996 | 8760941 | GenAge | ||||||||||||||||||||||||
2 | OB_003847 | Saccharomyces cerevisiae |
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increased | 36.00% | Overexpression extended mean and maximum lifespan by 36% and 54%, respectively. | Childress et al. | 1996 | 8760941 | Lifespan Observations Database (ID: 569) | |||||||||||||||||||||||||
3 | OB_004167 | Saccharomyces cerevisiae | BY4742 |
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increased | 10.00% | 26.1 | mean | 30 | ℃ | The lag2 deletion from the MATalpha haploid yeast orf deletion collection had a replicative life span that was not significantly different (p=0.2) from wild type BY4742 cells. | Kaeberlein et al. | 2005 | 15722108 | doi:10.1016/j.mad.2004.10.007 | Lifespan Observations Database (ID: 858) |
Homology Analysis
no homology analysis observation available
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Childress AM, Franklin DS, Pinswasdi C, Kale S:
LAG2, a gene that determines yeast longevity.
Microbiology (Reading, Engl). 1996; 142 ( Pt 8: 2289-97.
PubMed (ID: 8760941)
MeSH Terms: Fungal Proteins/biosynthesis; Genes, Fungal; Saccharomyces cerevisiae Proteins; Saccharomyces cerevisiae/physiology - Kaeberlein M, Kirkland KT, Fields S, Kennedy BK:
Genes determining yeast replicative life span in a long-lived genetic background.
Mech Ageing Dev. 2005; 126: 491-504.
PubMed (ID: 15722108), doi:10.1016/j.mad.2004.10.007
MeSH Terms: Cell Aging/genetics; Gene Expression Regulation, Fungal/genetics; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- NCBI Taxonomy
- PubMed