Gene: EEF2 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | EEF2 | ||||||||||||||||
NCBI Gene ID | : | 1938 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | EEF-2 | EEF2 | EF-2 | EF2 | ELONGATION FACTOR 2 | elongation factor 2 | EUKARYOTIC TRANSLATION ELONGATION FACTOR 2 | eukaryotic translation elongation factor 2 | POLYPEPTIDYL-tRNA TRANSLOCASE | polypeptidyl-tRNA translocase Source: GPSDB |
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Gene Homologs | : | AGOS_AFR142C (Eremothecium gossypii) | AT3G12915.1 (Arabidopsis thaliana) | EEF2 (Bos taurus) | EEF2 (Canis lupus familiaris) | EEF2 (Gallus gallus) | EEF2 (Homo sapiens) | EEF2 (Macaca mulatta) | Eef2 (Mus musculus) | Eef2 (Rattus norvegicus) | eef2l2 (Danio rerio) | EFT1 (Saccharomyces cerevisiae) | EFT2 (Saccharomyces cerevisiae) | eft201 (Schizosaccharomyces pombe) | eft202 (Schizosaccharomyces pombe) | KLLA0E02993g (Kluyveromyces lactis) | LOC100614367 (Pan troglodytes) | MGG_01742 (Magnaporthe oryzae) | NCU07700 (Neurospora crassa) | Os02g0519900 (Oryza sativa) | Os04g0118400 (Oryza sativa) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000074 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Elongation factor 2 | Homo sapiens | P13639 (UniProtKB/Swiss-Prot) | EF2_HUMAN (UniProtKB/Swiss-Prot) | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_009857 | Homo sapiens |
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EEF2 is involved in protein synthesis. Age-dependent changes to EEF2 in rats have been reported, which could account for the decline in protein synthesis in old animals [0540]. EEF2 has not been directly related to human ageing. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
EF2_HUMAN | P13639 | Elongation factor 2 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 858 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 EF2_HUMAN 1 MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGLVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLDKL 858
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Takahashi R, Mori N, Goto S:
Accumulation of heat-labile elongation factor 2 in the liver of mice and rats.
Exp Gerontol. 1985; 20: 325-31.
PubMed (ID: 3833544)
MeSH Terms: Liver/metabolism; Peptide Elongation Factors/metabolism - Rattan SI, Ward WF, Glenting M, Svendsen L, Riis B, Clark BF:
Dietary calorie restriction does not affect the levels of protein elongation factors in rat livers during ageing.
Mech Ageing Dev. 1991; 58: 85-91.
PubMed (ID: 2038215)
MeSH Terms: Aging/metabolism; Energy Intake; Liver/metabolism; Peptide Elongation Factors/metabolism - Riis B, Rattan SI, Palmquist K, Nilsson A, Nygård O, Clark BF:
Elongation factor 2-specific calcium and calmodulin dependent protein kinase III activity in rat livers varies with age and calorie restriction.
Biochem Biophys Res Commun. 1993; 192: 1210-6.
PubMed (ID: 8389544), doi:10.1006/bbrc.1993.1545
MeSH Terms: Aging/metabolism; Energy Intake; Liver/metabolism; Peptide Elongation Factors/metabolism; Protein Kinases/metabolism - Parrado J, Bougria M, Ayala A, Castaño A, Machado A:
Effects of aging on the various steps of protein synthesis: fragmentation of elongation factor 2.
Free Radic Biol Med. 1999; 26: 362-70.
PubMed (ID: 9895228)
MeSH Terms: Aging/metabolism; Peptide Elongation Factors/metabolism; Phosphoproteins/metabolism - Jäger D, Holtz J, Redpath NT, Müller SP, Pönicke K, Heinroth-Hoffmann I, Werdan K, Müller-Werdan U:
The ageing heart: influence of cellular and tissue ageing on total content and distribution of the variants of elongation factor-2.
Mech Ageing Dev. 2002; 123: 1305-19.
PubMed (ID: 12297334)
MeSH Terms: Aging/metabolism; Heart/physiology; Myocardium/metabolism; Peptide Elongation Factor 2/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot