Gene: Efemp1 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Efemp1 |
NCBI Gene ID |
: |
216616 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
Efemp1 | EGF-containing fibulin-like extracellular matrix protein 1 | epidermal growth factor-containing fibulin-like extracellular matrix protein 1 | Fbln3 | FIBL-3 | fibulin-3 | RP23-298H6.2
Source: GPSDB |
Gene Homologs |
: |
EFEMP1 (Bos taurus) | EFEMP1 (Canis lupus familiaris) | EFEMP1 (Gallus gallus) | EFEMP1 (Homo sapiens) | Efemp1 (Mus musculus) | EFEMP1 (Pan troglodytes) | Efemp1 (Rattus norvegicus) | LOC100332567 (Danio rerio) | LOC455416 (Pan troglodytes) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
decreased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_000083 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
EGF-containing fibulin-like extracellular matrix protein 1 |
Mus musculus |
Q8BPB5 (UniProtKB/Swiss-Prot) |
FBLN3_MOUSE (UniProtKB/Swiss-Prot) |
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_007633 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Efemp1 |
216616 |
|
|
Knockout mice exhibited an early onset of ageing-associated phenotypes including a 20% shorted median lifespan and 30% shorter maximum lifespan, decreased body mass, lordokyphosis, reduced hair growth, and atrophy. |
17872905 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_002564 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Efemp1 |
Mus musculus |
216616 |
loss of function |
- |
unknown |
unknown |
|
|
|
decreased |
-19.13% |
93 |
115 |
|
median |
|
|
|
Knockout mice exhibited a 20% shortened median lifespan. Other phenotypes: Also exhibited a 30% shorter maximum lifespan, decreased body mass, lordokyphosis, reduced hair growth, and atrophy. |
McLaughlin et al. |
2007 |
17872905 |
doi:10.1093/hmg/ddm264 |
Lifespan Observations Database (ID: 3814) |
2 |
OB_002565 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Efemp1 |
Mus musculus |
216616 |
loss of function |
- |
unknown |
unknown |
|
|
|
decreased |
-28.82% |
121 |
170 |
|
max |
|
|
|
Knockout mice exhibited a 20% shortened median lifespan. Other phenotypes: Also exhibited a 30% shorter maximum lifespan, decreased body mass, lordokyphosis, reduced hair growth, and atrophy. |
McLaughlin et al. |
2007 |
17872905 |
doi:10.1093/hmg/ddm264 |
Lifespan Observations Database (ID: 3815) |
3 |
OB_007634 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Efemp1 |
Mus musculus |
216616 |
Knockout |
- |
wildtype |
yes |
|
|
|
decreased |
-30.00% |
|
|
|
maximum |
|
|
|
Knockout mice exhibited an early onset of ageing-associated phenotypes including a 20% shorted median lifespan and 30% shorter maximum lifespan, decreased body mass, lordokyphosis, reduced hair growth, and atrophy. |
McLaughlin et al. |
2007 |
17872905 |
doi:10.1093/hmg/ddm264 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009546 |
|
2 |
The HomoloGene homology group 3028 contains 2 genes with experimental evidence for ageing relevance (EFEMP1 - Homo sapiens | Efemp1 - Mus musculus) and 7 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 3028 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- McLaughlin PJ, Bakall B, Choi J, Liu Z, Sasaki T, Davis EC, Marmorstein AD, Marmorstein LY:
Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice.
Hum Mol Genet. 2007; 16: 3059-70.
PubMed (ID: 17872905), doi:10.1093/hmg/ddm264
MeSH Terms: Aging, Premature/genetics; Extracellular Matrix Proteins/genetics; Hernia/genetics
Sources
Ageing-related Data Sources
Additional Data Sources