Gene: EGFR - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | EGFR | ||||||||||||||||
NCBI Gene ID | : | 1956 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | avian erythroblastic leukemia viral (v-erb-b) oncogene homolog | cell growth inhibiting protein 40 | cell proliferation-inducing protein 61 | EGFR | EPIDERMAL GROWTH FACTOR RECEPTOR | epidermal growth factor receptor | epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) | ERBB | ERBB1 | erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian) | HER1 | mENA | ONCOGENE ERBB | PIG61 | proto-oncogene c-ErbB-1 | receptor tyrosine-protein kinase erbB-1 | SA7 | SPECIES ANTIGEN 7 | V-ERB-B AVIAN ERYTHROBLASTIC LEUKEMIA VIRAL ONCOGENE HOMOLOG Source: GPSDB |
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Gene Homologs | : | EGFR (Bos taurus) | EGFR (Canis lupus familiaris) | EGFR (Gallus gallus) | EGFR (Homo sapiens) | EGFR (Macaca mulatta) | Egfr (Mus musculus) | EGFR (Pan troglodytes) | Egfr (Rattus norvegicus) | egfra (Danio rerio) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000086 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Epidermal growth factor receptor | Homo sapiens | P00533 (UniProtKB/Swiss-Prot) | EGFR_HUMAN (UniProtKB/Swiss-Prot) | Isoform 2 may act as an antagonist of EGF action. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009860 | Homo sapiens |
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EGFR is a glycoprotein and oncogene involved in cell proliferation. It has been associated with age-related declines in stress-response [1161], but it is not known whether this is a cause or effect of ageing. EGFR has also been related to age-related declines in rat hepatocytes [0346]. Whether EGFR plays a role in human ageing remains to be determined. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009443 |
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1 | The HomoloGene homology group 74545 contains 1 gene with experimental evidence for ageing relevance (EGFR - Homo sapiens) and 8 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 74545 |
Sequences
EGFR_HUMAN | P00533 | Epidermal growth factor receptor (Homo sapiens) from UniProtKB/Swiss-Prot Length: 1210 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 1210 EGFR_HUMAN 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA 1210
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Reenstra WR, Yaar M, Gilchrest BA:
Effect of donor age on epidermal growth factor processing in man.
Exp Cell Res. 1993; 209: 118-22.
PubMed (ID: 8223996), doi:10.1006/excr.1993.1291
MeSH Terms: Aging; Epidermal Growth Factor/metabolism; Receptor, Epidermal Growth Factor/metabolism - Tran KT, Rusu SD, Satish L, Wells A:
Aging-related attenuation of EGF receptor signaling is mediated in part by increased protein tyrosine phosphatase activity.
Exp Cell Res. 2003; 289: 359-67.
PubMed (ID: 14499637)
MeSH Terms: Adaptor Proteins, Signal Transducing; Cell Aging/physiology; Fibroblasts/metabolism; Protein Tyrosine Phosphatases/metabolism; Receptor, Epidermal Growth Factor/metabolism; Receptors, Cell Surface; Signal Transduction/physiology; Up-Regulation/physiology - Majumdar AP:
Regulation of gastrointestinal mucosal growth during aging.
J Physiol Pharmacol. 2003; 54 Suppl 4: 143-54.
PubMed (ID: 15075456)
MeSH Terms: Aging/physiology; Gastric Mucosa/growth & development; Gastrointestinal Tract/growth & development - Holbro T, Hynes NE:
ErbB receptors: directing key signaling networks throughout life.
Annu Rev Pharmacol Toxicol. 2004; 44: 195-217.
PubMed (ID: 14744244), doi:10.1146/annurev.pharmtox.44.101802.121440
MeSH Terms: Aging/metabolism; Receptor, Epidermal Growth Factor/metabolism; Receptor, erbB-2/metabolism; Receptor, erbB-3/metabolism; Signal Transduction/physiology - Enwere E, Shingo T, Gregg C, Fujikawa H, Ohta S, Weiss S:
Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination.
J Neurosci. 2004; 24: 8354-65.
PubMed (ID: 15385618), doi:10.1523/JNEUROSCI.2751-04.2004
MeSH Terms: Aging/physiology; Cell Proliferation; Discrimination (Psychology)/physiology; Olfactory Bulb/metabolism; Receptor, Epidermal Growth Factor/metabolism; Smell/physiology - Tureaud J, Sarkar FH, Fligiel SE, Kulkarni S, Jaszewski R, Reddy K, Yu Y, Majumdar AP:
Increased expression of EGFR in gastric mucosa of aged rats.
Am J Physiol. 1997; 273: G389-98.
PubMed (ID: 9277418)
MeSH Terms: Aging/metabolism; Gastric Mucosa/metabolism; Receptor, Epidermal Growth Factor/metabolism - Zhao YY, Sawyer DR, Baliga RR, Opel DJ, Han X, Marchionni MA, Kelly RA:
Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes.
J Biol Chem. 1998; 273: 10261-9.
PubMed (ID: 9553078)
MeSH Terms: Aging/genetics; Cell Division/physiology; Cell Survival/physiology; Heart Ventricles/cytology; Nerve Tissue Proteins/metabolism; Receptor, Epidermal Growth Factor/genetics; Receptor, erbB-2/genetics - Chen B, Bronson RT, Klaman LD, Hampton TG, Wang JF, Green PJ, Magnuson T, Douglas PS, Morgan JP, Neel BG:
Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.
Nat Genet. 2000; 24: 296-9.
PubMed (ID: 10700187), doi:10.1038/73528
MeSH Terms: Aortic Valve/abnormalities; Protein Tyrosine Phosphatases/physiology; Pulmonary Valve/abnormalities; Receptor, Epidermal Growth Factor/physiology - Shiraha H, Gupta K, Drabik K, Wells A:
Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors.
J Biol Chem. 2000; 275: 19343-51.
PubMed (ID: 10764734), doi:10.1074/jbc.M000008200
MeSH Terms: Cell Aging; Epidermal Growth Factor/metabolism; Receptor, Epidermal Growth Factor/metabolism; Signal Transduction - Hutter D, Yo Y, Chen W, Liu P, Holbrook NJ, Roth GS, Liu Y:
Age-related decline in Ras/ERK mitogen-activated protein kinase cascade is linked to a reduced association between Shc and EGF receptor.
J Gerontol A Biol Sci Med Sci. 2000; 55: B125-34.
PubMed (ID: 10795716)
MeSH Terms: Adaptor Proteins, Signal Transducing; Cell Aging/physiology; MAP Kinase Signaling System/physiology; Receptor, Epidermal Growth Factor/metabolism; Ribosomal Protein S6 Kinases/metabolism; ras Proteins/metabolism - Botella JA, Kretzschmar D, Kiermayer C, Feldmann P, Hughes DA, Schneuwly S:
Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap.
Mol Biol Cell. 2003; 14: 241-50.
PubMed (ID: 12529440), PubMed Central (ID: PMC140241), doi:10.1091/mbc.E02-05-0297
MeSH Terms: Aging/physiology; Brain/physiology; Drosophila/physiology; Receptor, Epidermal Growth Factor/metabolism; Signal Transduction/physiology; ras GTPase-Activating Proteins/metabolism - Smith LL, Coller HA, Roberts JM:
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation.
Nat Cell Biol. 2003; 5: 474-9.
PubMed (ID: 12717449), doi:10.1038/ncb985
MeSH Terms: Breast/enzymology; Cell Division/genetics; Cell Transformation, Neoplastic/metabolism; Epithelial Cells/enzymology; Gene Expression Regulation, Neoplastic/genetics; Neoplasms/enzymology; Telomerase/metabolism - Li J, Holbrook NJ:
Common mechanisms for declines in oxidative stress tolerance and proliferation with aging.
Free Radic Biol Med. 2003; 35: 292-9.
PubMed (ID: 12885591)
MeSH Terms: Aging; Oxidative Stress
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot