Gene: EGF - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | EGF | ||||||||||||||||
NCBI Gene ID | : | 1950 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | beta-urogastrone | EGF | EPIDERMAL GROWTH FACTOR | epidermal growth factor | epidermal growth factor (beta-urogastrone) | HOMG4 | pro-epidermal growth factor | URG | UROGASTRONE Source: GPSDB |
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Gene Homologs | : | EGF (Bos taurus) | EGF (Canis lupus familiaris) | egf (Danio rerio) | EGF (Gallus gallus) | EGF (Homo sapiens) | EGF (Macaca mulatta) | Egf (Mus musculus) | EGF (Pan troglodytes) | Egf (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000087 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Epidermal growth factor | Homo sapiens | E7EVD2 (UniProtKB/TrEMBL) | E7EVD2_HUMAN (UniProtKB/TrEMBL) | View | |
Pro-epidermal growth factor | Homo sapiens | P01133 (UniProtKB/Swiss-Prot) | EGF_HUMAN (UniProtKB/Swiss-Prot) | EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009859 | Homo sapiens |
|
EGF stimulates the growth of several epidermal and epithelial cell types. It is also involved in differentiation [0366]. Expression of EGF in transgenic mice causes stunted growth [0367]. An attenuation of EGF signalling has been reported with age [0346], but it is unclear whether these are causes or effects of ageing. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008845 |
|
1 | The HomoloGene homology group 1483 contains 1 gene with experimental evidence for ageing relevance (EGF - Homo sapiens) and 8 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 1483 |
Sequences
E7EVD2_HUMAN | E7EVD2 | Epidermal growth factor (Homo sapiens) from UniProtKB/TrEMBL Length: 1166 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 E7EVD2_HUMAN 1 MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ 1166
EGF_HUMAN | P01133 | Pro-epidermal growth factor (Homo sapiens) from UniProtKB/Swiss-Prot Length: 1207 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 EGF_HUMAN 1 MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ 1207
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Carpenter G, Cohen S:
Epidermal growth factor.
Annu Rev Biochem. 1979; 48: 193-216.
PubMed (ID: 382984), doi:10.1146/annurev.bi.48.070179.001205
MeSH Terms: Epidermal Growth Factor/pharmacology; Epidermal Growth Factor/physiology; Peptides/pharmacology - Chan SY, Wong RW:
Expression of epidermal growth factor in transgenic mice causes growth retardation.
J Biol Chem. 2000; 275: 38693-8.
PubMed (ID: 11001946), doi:10.1074/jbc.M004189200
MeSH Terms: Bone Development; Epidermal Growth Factor/physiology; Growth Disorders/genetics - Li J, Holbrook NJ:
Common mechanisms for declines in oxidative stress tolerance and proliferation with aging.
Free Radic Biol Med. 2003; 35: 292-9.
PubMed (ID: 12885591)
MeSH Terms: Aging; Oxidative Stress - Majumdar AP:
Regulation of gastrointestinal mucosal growth during aging.
J Physiol Pharmacol. 2003; 54 Suppl 4: 143-54.
PubMed (ID: 15075456)
MeSH Terms: Aging/physiology; Gastric Mucosa/growth & development; Gastrointestinal Tract/growth & development - Enwere E, Shingo T, Gregg C, Fujikawa H, Ohta S, Weiss S:
Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination.
J Neurosci. 2004; 24: 8354-65.
PubMed (ID: 15385618), doi:10.1523/JNEUROSCI.2751-04.2004
MeSH Terms: Aging/physiology; Cell Proliferation; Discrimination (Psychology)/physiology; Olfactory Bulb/metabolism; Receptor, Epidermal Growth Factor/metabolism; Smell/physiology - Zhong N, Radu G, Ju W, Brown WT:
Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C.
Biochem Biophys Res Commun. 2005; 338: 855-61.
PubMed (ID: 16248985), doi:10.1016/j.bbrc.2005.10.020
MeSH Terms: Cell Nucleus/metabolism; DNA-Binding Proteins/metabolism; Epidermal Growth Factor/metabolism; Heterogeneous-Nuclear Ribonucleoproteins/metabolism; Lamin Type A/metabolism; Progeria/metabolism; Ubiquitin-Conjugating Enzymes/metabolism - Ota H, Tokunaga E, Chang K, Hikasa M, Iijima K, Eto M, Kozaki K, Akishita M, Ouchi Y, Kaneki M:
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
Oncogene. 2006; 25: 176-85.
PubMed (ID: 16170353), doi:10.1038/sj.onc.1209049
MeSH Terms: Benzamides/pharmacology; Cell Aging/drug effects; Enzyme Activation/drug effects; Genes, ras/physiology; Naphthols/pharmacology; Signal Transduction/drug effects; p38 Mitogen-Activated Protein Kinases/metabolism - Reenstra WR, Yaar M, Gilchrest BA:
Effect of donor age on epidermal growth factor processing in man.
Exp Cell Res. 1993; 209: 118-22.
PubMed (ID: 8223996), doi:10.1006/excr.1993.1291
MeSH Terms: Aging; Epidermal Growth Factor/metabolism; Receptor, Epidermal Growth Factor/metabolism - Matuoka K, Shibasaki F, Shibata M, Takenawa T:
Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.
EMBO J. 1993; 12: 3467-73.
PubMed (ID: 8253073), PubMed Central (ID: PMC413623)
MeSH Terms: Adaptor Proteins, Signal Transducing; Cell Division/physiology; Cytoskeleton/ultrastructure; Epidermal Growth Factor/pharmacology; GTP-Binding Proteins/metabolism; Platelet-Derived Growth Factor/pharmacology; Proteins/physiology; Signal Transduction - Liu Y, Guyton KZ, Gorospe M, Xu Q, Kokkonen GC, Mock YD, Roth GS, Holbrook NJ:
Age-related decline in mitogen-activated protein kinase activity in epidermal growth factor-stimulated rat hepatocytes.
J Biol Chem. 1996; 271: 3604-7.
PubMed (ID: 8631968)
MeSH Terms: Aging/metabolism; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Cell Cycle Proteins; Epidermal Growth Factor/pharmacology; Liver/enzymology; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases - Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG:
The p66shc adaptor protein controls oxidative stress response and life span in mammals.
Nature. 1999; 402: 309-13.
PubMed (ID: 10580504), doi:10.1038/46311
MeSH Terms: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Longevity/physiology; Oxidative Stress; Proteins/physiology - Wong RW, Kwan RW, Mak PH, Mak KK, Sham MH, Chan SY:
Overexpression of epidermal growth factor induced hypospermatogenesis in transgenic mice.
J Biol Chem. 2000; 275: 18297-301.
PubMed (ID: 10748057), doi:10.1074/jbc.M001965200
MeSH Terms: Epidermal Growth Factor/physiology; Oligospermia/etiology; Spermatogenesis/physiology - Shiraha H, Gupta K, Drabik K, Wells A:
Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors.
J Biol Chem. 2000; 275: 19343-51.
PubMed (ID: 10764734), doi:10.1074/jbc.M000008200
MeSH Terms: Cell Aging; Epidermal Growth Factor/metabolism; Receptor, Epidermal Growth Factor/metabolism; Signal Transduction - Hutter D, Yo Y, Chen W, Liu P, Holbrook NJ, Roth GS, Liu Y:
Age-related decline in Ras/ERK mitogen-activated protein kinase cascade is linked to a reduced association between Shc and EGF receptor.
J Gerontol A Biol Sci Med Sci. 2000; 55: B125-34.
PubMed (ID: 10795716)
MeSH Terms: Adaptor Proteins, Signal Transducing; Cell Aging/physiology; MAP Kinase Signaling System/physiology; Receptor, Epidermal Growth Factor/metabolism; Ribosomal Protein S6 Kinases/metabolism; ras Proteins/metabolism - De-Fraja C, Conti L, Govoni S, Battaini F, Cattaneo E:
STAT signalling in the mature and aging brain.
Int J Dev Neurosci. 2000; 18: 439-46.
PubMed (ID: 10817928)
MeSH Terms: Aging/physiology; Brain/growth & development; Brain/metabolism; DNA-Binding Proteins/metabolism; Signal Transduction/physiology; Trans-Activators/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL