Gene: HSP90AA1 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | HSP90AA1 | ||||||||||||||||
NCBI Gene ID | : | 3320 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | EL52 | epididymis luminal secretory protein 52 | FLJ31884 | heat shock 86 kDa | heat shock 90kD protein 1, alpha | heat shock 90kD protein 1, alpha-like 4 | heat shock 90kD protein, alpha-like 4 | heat shock 90kDa protein 1, alpha | heat shock protein 90kDa alpha (cytosolic), class A member 1 | heat shock protein HSP 90-alpha | HEAT-SHOCK 90-KD PROTEIN 1, ALPHA | HEAT-SHOCK 90-KD PROTEIN 1, ALPHA-LIKE 4 | HEAT-SHOCK PROTEIN, 90-KD, ALPHA, CLASS A, MEMBER 1 | HSP 86 | HSP86 | Hsp89 | HSP89-ALPHA | HSP89A | Hsp90 | HSP90A | HSP90AA1 | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | LAP2 | LIPOPOLYSACCHARIDE-ASSOCIATED PROTEIN 2 | LPS-ASSOCIATED PROTEIN 2 | renal carcinoma antigen NY-REN-38 Source: GPSDB |
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Gene Homologs | : | AGOS_AFL148C (Eremothecium gossypii) | HSC82 (Saccharomyces cerevisiae) | HSP82 (Saccharomyces cerevisiae) | HSP90-1 (Arabidopsis thaliana) | HSP90AA1 (Bos taurus) | HSP90AA1 (Canis lupus familiaris) | HSP90AA1 (Gallus gallus) | HSP90AA1 (Homo sapiens) | HSP90AA1 (Macaca mulatta) | Hsp90aa1 (Mus musculus) | HSP90AA1 (Pan troglodytes) | Hsp90aa1 (Rattus norvegicus) | hsp90aa1.2 (Danio rerio) | KLLA0D12958g (Kluyveromyces lactis) | MGG_06759 (Magnaporthe oryzae) | NCU04142 (Neurospora crassa) | swo1 (Schizosaccharomyces pombe) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000098 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Heat shock protein HSP 90-alpha | Homo sapiens | P07900 (UniProtKB/Swiss-Prot) | HS90A_HUMAN (UniProtKB/Swiss-Prot) | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009634 | Homo sapiens |
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Also known as Hsp90, HSP90AA1 is a molecular chaperone. Similar proteins have been suggested to impact on the ageing process of model organisms [0632]. HSP90AA1 is affected by ageing in rats [0909], though no evidence has directly linked HSP90AA1 to human ageing. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009022 | 2 | The HomoloGene homology group 68464 contains 2 genes with experimental evidence for ageing relevance (HSC82 - Saccharomyces cerevisiae | HSP90AA1 - Homo sapiens) and 15 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 68464 |
Sequences
HS90A_HUMAN | P07900 | Heat shock protein HSP 90-alpha (Homo sapiens) from UniProtKB/Swiss-Prot Length: 732 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 HS90A_HUMAN 1 MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD 732
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Bornman L, Polla BS, Gericke GS:
Heat-shock protein 90 and ubiquitin: developmental regulation during myogenesis.
Muscle Nerve. 1996; 19: 574-80.
PubMed (ID: 8618554), doi:10.1002/(SICI)1097-4598(199605)19:5<574::AID-MUS4>3.0.CO;2-8
MeSH Terms: Aging/metabolism; HSP90 Heat-Shock Proteins/metabolism; Muscle Development; Ubiquitins/metabolism - Selsby JT, Judge AR, Yimlamai T, Leeuwenburgh C, Dodd SL:
Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats.
Exp Gerontol. 2005; 40: 37-42.
PubMed (ID: 15664730), doi:10.1016/j.exger.2004.08.012
MeSH Terms: Caloric Restriction; Heat-Shock Proteins/metabolism; Muscle, Skeletal/metabolism; Proteasome Endopeptidase Complex/metabolism - Conconi M, Friguet B:
Proteasome inactivation upon aging and on oxidation-effect of HSP 90.
Mol Biol Rep. 1997; 24: 45-50.
PubMed (ID: 9228280)
MeSH Terms: Aging/physiology; Cysteine Endopeptidases/metabolism; HSP90 Heat-Shock Proteins/metabolism; Multienzyme Complexes/metabolism - Rutherford SL, Lindquist S:
Hsp90 as a capacitor for morphological evolution.
Nature. 1998; 396: 336-42.
PubMed (ID: 9845070), doi:10.1038/24550
MeSH Terms: Directed Molecular Evolution; Drosophila Proteins; HSP90 Heat-Shock Proteins/physiology - Verbeke P, Fonager J, Clark BF, Rattan SI:
Heat shock response and ageing: mechanisms and applications.
Cell Biol Int. 2001; 25: 845-57.
PubMed (ID: 11518492), doi:10.1006/cbir.2001.0789
MeSH Terms: Aging; Heat-Shock Response - Queitsch C, Sangster TA, Lindquist S:
Hsp90 as a capacitor of phenotypic variation.
Nature. 2002; 417: 618-24.
PubMed (ID: 12050657), doi:10.1038/nature749
MeSH Terms: Arabidopsis/genetics; Arabidopsis/metabolism; Genetic Variation/genetics; HSP90 Heat-Shock Proteins/metabolism - Nardai G, Csermely P, Söti C:
Chaperone function and chaperone overload in the aged. A preliminary analysis.
Exp Gerontol. 2002; 37: 1257-62.
PubMed (ID: 12470839)
MeSH Terms: Aging/metabolism; Liver/metabolism; Molecular Chaperones/physiology - Takahashi R, Toyoda E, Aoki Y, Suzuki KT, Goto S:
Paradoxical increase of heat-shock response with age in a substrain of F344 rats: comparison between F344/DuCrj and F344/Jcl.
Mech Ageing Dev. 2002; 123: 1605-15.
PubMed (ID: 12470898)
MeSH Terms: Aging/physiology; Heat-Shock Proteins; Heat-Shock Response/physiology; Hepatocytes/physiology - Sollars V, Lu X, Xiao L, Wang X, Garfinkel MD, Ruden DM:
Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution.
Nat Genet. 2003; 33: 70-4.
PubMed (ID: 12483213), doi:10.1038/ng1067
MeSH Terms: Biological Evolution; Drosophila melanogaster/genetics; Drosophila melanogaster/growth & development; HSP90 Heat-Shock Proteins/genetics - Murtha JM, Keller ET:
Characterization of the heat shock response in mature zebrafish (Danio rerio).
Exp Gerontol. 2003; 38: 683-91.
PubMed (ID: 12814804)
MeSH Terms: Aging/metabolism; Heat-Shock Proteins/biosynthesis; Heat-Shock Response/physiology; Zebrafish/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot