Gene: ERN1 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | ERN1 | ||||||||||||
NCBI Gene ID | : | 2081 | ||||||||||||
Species | : | Homo sapiens | ||||||||||||
Gene Synonyms | : | endoplasmic reticulum to nucleus signaling 1 | ENDOPLASMIC RETICULUM-TO-NUCLEUS SIGNALING 1 | endoplasmic reticulum-to-nucleus signaling 1 | ER to nucleus signalling 1 | ERN1 | hIRE1p | inositol-requiring 1 | inositol-requiring enzyme 1 | INOSITOL-REQUIRING ENZYME 1, S. CEREVISIAE, HOMOLOG OF | inositol-requiring protein 1 | IRE1 | IRE1-ALPHA | ire1-alpha | IRE1A | IRE1a | IRE1P | protein kinase/endoribonuclease | serine/threonine-protein kinase/endoribonuclease IRE1 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP004176 (Anopheles gambiae) | ERN1 (Bos taurus) | ERN1 (Canis lupus familiaris) | ERN1 (Gallus gallus) | ERN1 (Homo sapiens) | ERN1 (Macaca mulatta) | Ern1 (Mus musculus) | ERN1 (Pan troglodytes) | Ern1 (Rattus norvegicus) | ern2 (Danio rerio) | ire-1 (Caenorhabditis elegans) | Ire1 (Drosophila melanogaster) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000115 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Serine/threonine-protein kinase/endoribonuclease IRE1 | Homo sapiens | O75460 (UniProtKB/Swiss-Prot) | ERN1_HUMAN (UniProtKB/Swiss-Prot) | Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009011 | 1 | The HomoloGene homology group 55580 contains 1 gene with experimental evidence for ageing relevance (ire-1 - Caenorhabditis elegans) and 11 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 55580 |
Sequences
ERN1_HUMAN | O75460 | Serine/threonine-protein kinase/endoribonuclease IRE1 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 977 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 ERN1_HUMAN 1 MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL 977
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot