Gene: EPS8 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | EPS8 | ||||||||||||||||
NCBI Gene ID | : | 2059 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | epidermal growth factor receptor kinase substrate 8 | EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 8 | epidermal growth factor receptor pathway substrate 8 | EPS8 Source: GPSDB |
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Gene Homologs | : | EPS8 (Bos taurus) | EPS8 (Canis lupus familiaris) | EPS8 (Gallus gallus) | EPS8 (Homo sapiens) | EPS8 (Macaca mulatta) | Eps8 (Mus musculus) | EPS8 (Pan troglodytes) | Eps8 (Rattus norvegicus) | zgc:56041 (Danio rerio) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000121 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Epidermal growth factor receptor kinase substrate 8 | Homo sapiens | Q12929 (UniProtKB/Swiss-Prot) | EPS8_HUMAN (UniProtKB/Swiss-Prot) | Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009866 | Homo sapiens |
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EPS8 knockout mice appear to be caloric restricted, most probably due to an impaired fat absorption, and show a lean phenotype and increased lifespan [2158]. EPS8 was shown to be involved in several type of cancer [2159] [2160] [2161] [2162]. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008386 |
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2 | The HomoloGene homology group 3272 contains 2 genes with experimental evidence for ageing relevance (EPS8 - Homo sapiens | Eps8 - Mus musculus) and 7 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 3272 |
Sequences
EPS8_HUMAN | Q12929 | Epidermal growth factor receptor kinase substrate 8 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 822 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 EPS8_HUMAN 1 MNGHISNHPSSFGMYPSQMNGYGSSPTFSQTDREHGSKTSAKALYEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKRRPDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLFTPLNMVVQATGGPELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATMEQDLYQLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEPLKTQPKKYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPTPAPVPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQKKFHVPRQNVPVINITYDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCPEGARVYSQITVQKAALEDSSGSSELQEIMRRRQEKISAAASDSGVESFDEGSSH 822
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Welsch T, Endlich K, Giese T, Büchler MW, Schmidt J:
Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization.
Cancer Lett. 2007; 255: 205-18.
PubMed (ID: 17537571), doi:10.1016/j.canlet.2007.04.008
MeSH Terms: Actins/metabolism; Intracellular Signaling Peptides and Proteins/physiology; Pancreatic Neoplasms/metabolism; Pancreatic Neoplasms/ultrastructure; Pseudopodia/metabolism - Yap LF, Jenei V, Robinson CM, Moutasim K, Benn TM, Threadgold SP, Lopes V, Wei W, Thomas GJ, Paterson IC:
Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation.
Oncogene. 2009; 28: 2524-34.
PubMed (ID: 19448673), doi:10.1038/onc.2009.105
MeSH Terms: Carcinoma, Squamous Cell/pathology; Cell Movement; Integrins/metabolism; Intracellular Signaling Peptides and Proteins/metabolism; Mouth Neoplasms/pathology; rac1 GTP-Binding Protein/metabolism - Tocchetti A, Soppo CB, Zani F, Bianchi F, Gagliani MC, Pozzi B, Rozman J, Elvert R, Ehrhardt N, Rathkolb B, Moerth C, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Klingenspor M, Wolf E, Hrabé de Angelis M, Scanziani E, Tacchetti C, Scita G, Di Fiore PP, Offenhäuser N:
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
PLoS ONE. 2010; 5: e9468.
PubMed (ID: 20209148), PubMed Central (ID: PMC2830459), doi:10.1371/journal.pone.0009468
MeSH Terms: Actins/metabolism; Adaptor Proteins, Signal Transducing/physiology; Cytoskeletal Proteins/physiology; Intestines/metabolism - Chen H, Wu X, Pan ZK, Huang S:
Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis.
Cancer Res. 2010; 70: 9979-90.
PubMed (ID: 21118970), PubMed Central (ID: PMC3059077), doi:10.1158/0008-5472.CAN-10-2394
MeSH Terms: Adaptor Proteins, Signal Transducing/metabolism; Cytoskeletal Proteins/metabolism; Intracellular Signaling Peptides and Proteins/metabolism; Ovarian Neoplasms/pathology; SOS1 Protein/metabolism - Abdel-Rahman WM, Ruosaari S, Knuutila S, Peltomäki P:
Differential roles of EPS8 in carcinogenesis: loss of protein expression in a subset of colorectal carcinoma and adenoma.
World J Gastroenterol. 2012; 18: 3896-903.
PubMed (ID: 22876043), PubMed Central (ID: PMC3413063), doi:10.3748/wjg.v18.i29.3896
MeSH Terms: Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; Colorectal Neoplasms/genetics; Colorectal Neoplasms/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot