Gene: EPOR - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | EPOR | ||||||||||||||||
NCBI Gene ID | : | 2057 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | EPO-R | EPOR | ERYTHROPOIETIN RECEPTOR | erythropoietin receptor Source: GPSDB |
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Gene Homologs | : | EPOR (Bos taurus) | EPOR (Canis lupus familiaris) | epor (Danio rerio) | EPOR (Homo sapiens) | EPOR (Macaca mulatta) | Epor (Mus musculus) | Epor (Rattus norvegicus) | LOC100534667 (Danio rerio) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000123 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Erythropoietin receptor | Homo sapiens | P19235 (UniProtKB/Swiss-Prot) | EPOR_HUMAN (UniProtKB/Swiss-Prot) | Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009865 | Homo sapiens |
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Erythropoietin receptor involved in inflammation, EPOR has been related to age-related changes [0383]. It has not been shown to play a major role in ageing, though. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008200 |
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1 | The HomoloGene homology group 95 contains 1 gene with experimental evidence for ageing relevance (EPOR - Homo sapiens) and 7 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 95 |
Sequences
EPOR_HUMAN | P19235 | Erythropoietin receptor (Homo sapiens) from UniProtKB/Swiss-Prot Length: 508 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 EPOR_HUMAN 1 MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS 508
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Nakamura Y, Komatsu N, Nakauchi H:
A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells.
Science. 1992; 257: 1138-41.
PubMed (ID: 1324524)
MeSH Terms: Erythrocyte Aging/physiology; Receptors, Cell Surface/physiology - Moritz KM, Lim GB, Wintour EM:
Developmental regulation of erythropoietin and erythropoiesis.
Am J Physiol. 1997; 273: R1829-44.
PubMed (ID: 9435635)
MeSH Terms: Aging/physiology; Embryonic and Fetal Development; Erythropoiesis/physiology; Erythropoietin/biosynthesis; Gene Expression Regulation, Developmental; Receptors, Erythropoietin/biosynthesis - Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M:
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.
Cell. 2000; 102: 221-31.
PubMed (ID: 10943842)
MeSH Terms: Erythropoiesis/physiology; Mitogen-Activated Protein Kinases/physiology - Divoky V, Liu Z, Ryan TM, Prchal JF, Townes TM, Prchal JT:
Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene.
Proc Natl Acad Sci USA. 2001; 98: 986-91.
PubMed (ID: 11158582), PubMed Central (ID: PMC14696), doi:10.1073/pnas.98.3.986
MeSH Terms: Polycythemia/genetics; Receptors, Erythropoietin/genetics; Sequence Deletion - Digicaylioglu M, Lipton SA:
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades.
Nature. 2001; 412: 641-7.
PubMed (ID: 11493922), doi:10.1038/35088074
MeSH Terms: Apoptosis; Erythropoietin/physiology; NF-kappa B/metabolism; Neurons/metabolism; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot