Gene: RAD27 - Saccharomyces cerevisiae(see also ageing factor AF_008792 *)
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | RAD27 | ||||||||||||||||
NCBI Gene ID | : | 853747 * | ||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||
Gene Synonyms | : | ERC11 | FEN1 | RAD27 | Rad27p | RTH1 | YKL113C | YKL510 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP011448 (Anopheles gambiae) | crn-1 (Caenorhabditis elegans) | FEN1 (Arabidopsis thaliana) | FEN1 (Bos taurus) | FEN1 (Canis lupus familiaris) | Fen1 (Drosophila melanogaster) | FEN1 (Gallus gallus) | FEN1 (Homo sapiens) | FEN1 (Macaca mulatta) | Fen1 (Mus musculus) | FEN1 (Pan troglodytes) | Fen1 (Rattus norvegicus) | KLLA0F02992g (Kluyveromyces lactis) | MGG_03419 (Magnaporthe oryzae) | NCU10776 (Neurospora crassa) | Os05g0540100 (Oryza sativa) | rad2 (Schizosaccharomyces pombe) | RAD27 (Saccharomyces cerevisiae) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000129 | ||||||||||||||||
Download | : | XML |
*
AgeFactDB contains further genes associated with gene symbol RAD27 and the species Saccharomyces cerevisiae: AF_008792
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_005772 | Saccharomyces cerevisiae |
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Mutations result in signs of premature ageing. | 12024027 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_005774 | Saccharomyces cerevisiae |
|
decreased | -50.00% | unknown | Mean chronological lifespan decreased in the a strain by more than 50% | Laschober et al. | 2010 | 20883526 | doi:10.1111/j.1474-9726.2010.00637.x | GenAge | |||||||||||||||||||||||
2 | OB_005773 | Saccharomyces cerevisiae |
|
decreased | unknown | Mutations result in signs of premature ageing. | Hoopes et al. | 2002 | 12024027 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008389 | 2 | The HomoloGene homology group 3034 contains 2 genes with experimental evidence for ageing relevance (FEN1 - Homo sapiens | RAD27 - Saccharomyces cerevisiae) and 16 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 3034 |
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Hoopes LL, Budd M, Choe W, Weitao T, Campbell JL:
Mutations in DNA replication genes reduce yeast life span.
Mol Cell Biol. 2002; 22: 4136-46.
PubMed (ID: 12024027), PubMed Central (ID: PMC133874)
MeSH Terms: Adenosine Triphosphatases/genetics; DNA Helicases/genetics; DNA Replication/genetics; DNA-Binding Proteins; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Yeasts/physiology - Laschober GT, Ruli D, Hofer E, Muck C, Carmona-Gutierrez D, Ring J, Hutter E, Ruckenstuhl C, Micutkova L, Brunauer R, Jamnig A, Trimmel D, Herndler-Brandstetter D, Brunner S, Zenzmaier C, Sampson N, Breitenbach M, Fröhlich KU, Grubeck-Loebenstein B, Berger P, Wieser M, Grillari-Voglauer R, Thallinger GG, Grillari J, Trajanoski Z, Madeo F, Lepperdinger G, Jansen-Dürr P:
Identification of evolutionarily conserved genetic regulators of cellular aging.
Aging Cell. 2010; 9: 1084-97.
PubMed (ID: 20883526), PubMed Central (ID: PMC2997327), doi:10.1111/j.1474-9726.2010.00637.x
MeSH Terms: Cell Aging/genetics; Evolution, Molecular; Gene Expression Regulation
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed