Gene: Emd - Rattus norvegicus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Emd | ||||||||||||
NCBI Gene ID | : | 25437 | ||||||||||||
Species | : | Rattus norvegicus | ||||||||||||
Gene Synonyms | : | Emd | emerin Source: GPSDB |
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Gene Homologs | : | EMD (Bos taurus) | EMD (Homo sapiens) | EMD (Macaca mulatta) | Emd (Mus musculus) | EMD (Pan troglodytes) | Emd (Rattus norvegicus) | LOC492249 (Canis lupus familiaris) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000198 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Emerin | Rattus norvegicus | Q63190 (UniProtKB/Swiss-Prot) | EMD_RAT (UniProtKB/Swiss-Prot) | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | ||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008638 |
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1 | The HomoloGene homology group 91 contains 1 gene with experimental evidence for ageing relevance (EMD - Homo sapiens) and 6 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 91 |
Sequences
EMD_RAT | Q63190 | Emerin (Rattus norvegicus) from UniProtKB/Swiss-Prot Length: 260 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 EMD_RAT 1 MDDYAVLSDTELAAVLRQYNIPHGPILGSTRKLYEKKIFEYETQRRRLSPPSSSSSSFSYRFSDLDSASVDSDMYDLPKKEDALLYQSKDYNDDYYEESYLTTRTYGEPESVGMSKSFRRPGTSLVDADDTFHHQVRDDIFSSSEEEGKDRERPIYGRDSAYQSIAEYRPISNVSRSSLGLSYYPRSSTSSVSSSSSSPSSWLTRRAIRPEKQAPTAALGQDRQVPLWGQLLLFLAFATFLLFVYYSIQAQEGNPFWMDP 260
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot