Gene: Eps8 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Eps8 | ||||||||||||||||
NCBI Gene ID | : | 13860 | ||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||
Gene Synonyms | : | epidermal growth factor receptor kinase substrate 8 | epidermal growth factor receptor pathway substrate 8 | Eps8 Source: GPSDB |
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Gene Homologs | : | EPS8 (Bos taurus) | EPS8 (Canis lupus familiaris) | EPS8 (Gallus gallus) | EPS8 (Homo sapiens) | EPS8 (Macaca mulatta) | Eps8 (Mus musculus) | EPS8 (Pan troglodytes) | Eps8 (Rattus norvegicus) | zgc:56041 (Danio rerio) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000207 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Epidermal growth factor receptor kinase substrate 8 | Mus musculus | Q08509 (UniProtKB/Swiss-Prot) | EPS8_MOUSE (UniProtKB/Swiss-Prot) | Upon binding to EGF receptor/EGFR enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_006299 | Mus musculus |
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increased | 9.00% | maximum | Eps8 KO mice show a lean phenotype and increased lifespan. Mice appear to be caloric restricted, most probably due to an impaired fat absorption. Median survival of Eps8 KO mice was increased by 26%, mean survival by 37% and maximum survival by 9%. Lifespan was significantly extended both in male and female Eps8 KO mice. | Tocchetti et al. | 2010 | 20209148 | doi:10.1371/journal.pone.0009468 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | ||||||||||||||||||||||||||||||
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1 | OB_008386 |
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2 | The HomoloGene homology group 3272 contains 2 genes with experimental evidence for ageing relevance (EPS8 - Homo sapiens | Eps8 - Mus musculus) and 7 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 3272 |
Sequences
EPS8_MOUSE | Q08509 | Epidermal growth factor receptor kinase substrate 8 (Mus musculus) from UniProtKB/Swiss-Prot Length: 821 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 EPS8_MOUSE 1 MNGHMSNRSSGYGVYPSQLNGYGSSPPYSQMDREHSSRTSAKALYEQRKNYARDSVSSVSDVSQYRVEHLTTFVLDRKDAMITVEDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTISHCQAVVHACSYDSILALVCKEPTQSKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKRRPEALRMIAKADPGIPPPPRAPAPVPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKSKKSKRKGPGEGVLTLRAKPPPPDEFVDCFQKFKHGFNLLAKLKSHIQNPSASDLVHFLFTPLNMVVQATGGPELASSVLSPLLTKDTVDFLNYTATAEERKLWMSLGDSWVKVRAEWPKEQFIPPYVPRFRNGWEPPMLNFMGAPTEQDMYQLAESVANAEHQRKQDSKRLSTEHSNVSDYPPADGYAYSSSMYHRGPHADHGEAAMPFKSTPNHQVDRNYDAVKTQPKKYAKSKYDFVARNSSELSVMKDDVLEILDDRRQWWKVRNASGDSGFVPNNILDIMRTPESGVGRADPPYTHTIQKQRTEYGLRSADTPSAPSPPPTPAPVPVPLPPSVPAPVSVPKVPANVTRQNSSSSDSGGSIVRDSQRYKQLPVDRRKSQMEEVQDELFQRLTIGRSAAQRKFHVPRQNVPVINITYDSSPEEVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRSVCPEGARVFNQITVQKAALEDSNGSSELQEIMRRRQEKISAAASDSGVESFDEGSSH 821
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Tocchetti A, Soppo CB, Zani F, Bianchi F, Gagliani MC, Pozzi B, Rozman J, Elvert R, Ehrhardt N, Rathkolb B, Moerth C, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Klingenspor M, Wolf E, Hrabé de Angelis M, Scanziani E, Tacchetti C, Scita G, Di Fiore PP, Offenhäuser N:
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
PLoS ONE. 2010; 5: e9468.
PubMed (ID: 20209148), PubMed Central (ID: PMC2830459), doi:10.1371/journal.pone.0009468
MeSH Terms: Actins/metabolism; Adaptor Proteins, Signal Transducing/physiology; Cytoskeletal Proteins/physiology; Intestines/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot