Gene: Fgf23 - Mus musculus(see also ageing factor AF_008890 *)
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_007772 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Fgf23 |
64654 |
|
|
Knockouts have a short lifespan and display symptoms of premature ageing ageing-like including kyphosis, muscle wasting, osteopenia, emphysema, uncoordinated movement, atherosclerosis, and atrophy of the intestinal villi, skin, thymus, and spleen. |
16436465 |
GenAge |
2 |
OB_007774 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Fgf23 |
64654 |
|
|
Lack of Fgf-23 activities results in extensive premature ageing-like features and early mortality of Fgf-23 −/− mice, while restoring the systemic effects of FGF-23 significantly ameliorates these phenotypes, with the resultant effect being improved growth, restored fertility, and significantly prolonged survival of double mutants. |
18729070 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_007773 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Fgf23 |
Mus musculus |
64654 |
Knockout |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Knockouts have a short lifespan and display symptoms of premature ageing ageing-like including kyphosis, muscle wasting, osteopenia, emphysema, uncoordinated movement, atherosclerosis, and atrophy of the intestinal villi, skin, thymus, and spleen. |
Razzaque et al. |
2006 |
16436465 |
doi:10.1096/fj.05-5432fje |
GenAge |
2 |
OB_007775 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Fgf23 |
Mus musculus |
64654 |
Conditional restoration of Fgf23 activity in Fgf23 knockout mice |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Lack of Fgf-23 activities results in extensive premature ageing-like features and early mortality of Fgf-23 −/− mice, while restoring the systemic effects of FGF-23 significantly ameliorates these phenotypes, with the resultant effect being improved growth, restored fertility, and significantly prolonged survival of double mutants. |
DeLuca et al. |
2008 |
18729070 |
doi:10.1002/path.2409 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008197 |
|
2 |
The HomoloGene homology group 10771 contains 2 genes with experimental evidence for ageing relevance (FGF23 - Homo sapiens | Fgf23 - Mus musculus) and 7 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 10771 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Razzaque MS, Sitara D, Taguchi T, St-Arnaud R, Lanske B:
Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process.
FASEB J. 2006; 20: 720-2.
PubMed (ID: 16436465), PubMed Central (ID: PMC2899884), doi:10.1096/fj.05-5432fje
MeSH Terms: Aging, Premature/metabolism; Fibroblast Growth Factors/deficiency; Fibroblast Growth Factors/metabolism; Vitamin D/metabolism
- DeLuca S, Sitara D, Kang K, Marsell R, Jonsson K, Taguchi T, Erben RG, Razzaque MS, Lanske B:
Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23.
J Pathol. 2008; 216: 345-55.
PubMed (ID: 18729070), PubMed Central (ID: PMC2776048), doi:10.1002/path.2409
MeSH Terms: Aging, Premature/genetics; Fibroblast Growth Factors/genetics; Osteoblasts/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources