Gene: SIP2 - Saccharomyces cerevisiae(see also ageing factor AF_009003 *)
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | SIP2 | ||||||||||||||||||||||||||||
NCBI Gene ID | : | 852664 * | ||||||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||
Gene Synonyms | : | G1155 | SIP2 | Sip2p | SPM2 | YGL208W Source: GPSDB |
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Gene Homologs | : | aakb-1 (Caenorhabditis elegans) | aakb-2 (Caenorhabditis elegans) | amk2 (Schizosaccharomyces pombe) | KINB1 (Arabidopsis thaliana) | LOC100856379 (Canis lupus familiaris) | MGG_06930 (Magnaporthe oryzae) | NCU03837 (Neurospora crassa) | Os05g0491200 (Oryza sativa) | PRKAB2 (Bos taurus) | prkab2 (Danio rerio) | PRKAB2 (Gallus gallus) | PRKAB2 (Homo sapiens) | PRKAB2 (Macaca mulatta) | Prkab2 (Mus musculus) | PRKAB2 (Pan troglodytes) | Prkab2 (Rattus norvegicus) | SIP2 (Saccharomyces cerevisiae) | ||||||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000354 | ||||||||||||||||||||||||||||
Download | : | XML |
*
AgeFactDB contains further genes associated with gene symbol SIP2 and the species Saccharomyces cerevisiae: AF_009003
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_005906 | Saccharomyces cerevisiae |
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Deletion results in reduced resistance to nutrient deprivation and a shorter lifespan accompanied by signs of accelerated ageing such as accumulation of extrachromosomal rDNA. | 10921902 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | |||||||||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | |||||||||||||||||||||
1 | OB_005908 | Saccharomyces cerevisiae |
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increased | 20.00% | unknown | Replicative lifespan increased by 20% in the alpha strain | Managbanag et al. | 2008 | 19030232 | doi:10.1371/journal.pone.0003802 | GenAge | ||||||||||||||||||||||||||||||
2 | OB_000614 | Saccharomyces cerevisiae | YB332 |
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increased | 13.79% | 33 | 29 | divisions | median | 30 | ℃ | mata | Deletion of SIP2 shortens life span by about 50%. This decreased in life span is suppressed by deletion of SNF4 | Ashrafi et al. | 2000 | 10921902 | Lifespan Observations Database (ID: 1881) | ||||||||||||||||||||||||
3 | OB_004166 | Saccharomyces cerevisiae | BY4742 |
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increased | 6.34% | 28.5 | 26.8 | mean | 30 | ℃ | matalpha | The sip2 deletion from the MATalpha haploid yeast orf deletion collection had a replicative life span that was not significantly different (p=0.2) from wild type BY4742 cells. | Kaeberlein et al. | 2005 | 15722108 | doi:10.1016/j.mad.2004.10.007 | Lifespan Observations Database (ID: 857) | ||||||||||||||||||||||||
4 | OB_002222 | Saccharomyces cerevisiae | YB332 |
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decreased | -51.61% | 15 | 31 | divisions | mean | 30 | ℃ | mata | Deletion of SIP2 shortens life span by about 50%. This decreased in life span is suppressed by deletion of SNF4 Other phenotypes: sip2 deletion strains show biomarkers of aging, including progressive sterility, enlargement and fragmentation of the nucleolus, redistribution of Sir3p to the nucleolus, and more rapid accumulation of ERCs [ 10921902]. Null mutation causes an increase in the intracellular ATP and NAD+ levels in both young cells (generation 0-1) and older cells (generation 4), but the increase is greater in older cells [ 10921902]. | Ashrafi et al. | 2000 | 10921902 | Lifespan Observations Database (ID: 34) | ||||||||||||||||||||||||
5 | OB_005907 | Saccharomyces cerevisiae |
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decreased | unknown | Deletion results in reduced resistance to nutrient deprivation and a shorter lifespan accompanied by signs of accelerated ageing such as accumulation of extrachromosomal rDNA. | Ashrafi et al. | 2000 | 10921902 | GenAge | ||||||||||||||||||||||||||||||||
6 | OB_005909 | Saccharomyces cerevisiae |
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increased | unknown | Mean chronological lifespan increased in the a strain | Matecic et al. | 2010 | 20421943 | doi:10.1371/journal.pgen.1000921 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_008372 | 3 | The HomoloGene homology group 38046 contains 3 genes with experimental evidence for ageing relevance (SIP2 - Saccharomyces cerevisiae | aakb-1 - Caenorhabditis elegans | aakb-2 - Caenorhabditis elegans) and 14 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 38046 |
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Ashrafi K, Lin SS, Manchester JK, Gordon JI:
Sip2p and its partner snf1p kinase affect aging in S. cerevisiae.
Genes Dev. 2000; 14: 1872-85.
PubMed (ID: 10921902), PubMed Central (ID: PMC316829)
MeSH Terms: DNA-Binding Proteins/metabolism; Fungal Proteins/metabolism; Protein-Serine-Threonine Kinases/metabolism; Repressor Proteins/metabolism; Saccharomyces cerevisiae Proteins; Saccharomyces cerevisiae/physiology; Trans-Activators - Kaeberlein M, Kirkland KT, Fields S, Kennedy BK:
Genes determining yeast replicative life span in a long-lived genetic background.
Mech Ageing Dev. 2005; 126: 491-504.
PubMed (ID: 15722108), doi:10.1016/j.mad.2004.10.007
MeSH Terms: Cell Aging/genetics; Gene Expression Regulation, Fungal/genetics; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae/genetics - Managbanag JR, Witten TM, Bonchev D, Fox LA, Tsuchiya M, Kennedy BK, Kaeberlein M:
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.
PLoS ONE. 2008; 3: e3802.
PubMed (ID: 19030232), PubMed Central (ID: PMC2583956), doi:10.1371/journal.pone.0003802
MeSH Terms: Cell Physiological Phenomena/genetics; Gene Regulatory Networks; Saccharomyces cerevisiae/cytology; Saccharomyces cerevisiae/genetics - Matecic M, Smith DL, Pan X, Maqani N, Bekiranov S, Boeke JD, Smith JS:
A microarray-based genetic screen for yeast chronological aging factors.
PLoS Genet. 2010; 6: e1000921.
PubMed (ID: 20421943), PubMed Central (ID: PMC2858703), doi:10.1371/journal.pgen.1000921
MeSH Terms: Oligonucleotide Array Sequence Analysis; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/physiology
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed