Gene: Pou1f1 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Pou1f1 | ||||||||||||||||||||||||
NCBI Gene ID | : | 18736 | ||||||||||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||||||||||
Gene Synonyms | : | dw | dwarf | GHF-1 | growth hormone factor 1 | Hmp1 | Pit-1 | Pit1 | Pit1-rs1 | pituitary specific transcription factor 1, related sequence 1 | pituitary-specific positive transcription factor 1 | pituitary-specific positive transcription factor 1 variant w | POU domain, class 1, transcription factor 1 | POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) | Pou1f1 Source: GPSDB |
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Gene Homologs | : | POU1F1 (Bos taurus) | POU1F1 (Canis lupus familiaris) | pou1f1 (Danio rerio) | POU1F1 (Gallus gallus) | POU1F1 (Homo sapiens) | POU1F1 (Macaca mulatta) | Pou1f1 (Mus musculus) | POU1F1 (Pan troglodytes) | Pou1f1 (Rattus norvegicus) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000402 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Pituitary-specific positive transcription factor 1 | Mus musculus | Q00286 (UniProtKB/Swiss-Prot) | PIT1_MOUSE (UniProtKB/Swiss-Prot) | Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_005724 | Mus musculus |
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increased | 40.00% | maximum | Deletion resulted in more than 40% increase in mean and maximal longevity on the relatively long-lived (C3H/HeJ x DW/J)F(1) background. | Flurkey et al. | 2001 | 11371619 | doi:10.1073/pnas.111158898 | GenAge | |||||||||||||||||||||||
2 | OB_000297 | Mus musculus | (C3H/HeJ x DW/J)F1 |
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increased | Homozygous Pit1 dw/dw animals show a 42% increase in mean life span. Other phenotypes: Mutant mice also show delays in age-dependent collagen cross-linking and age-dependent indices of immune system status [ 11371619]. Pit1 is required for normal development of the anterior pituitary. Activation of the Prop1 pathway is required for Pit1 expression [ 8961267] [ 8934515]. | Flurkey et al. | 2001 | 11371619 | doi:10.1073/pnas.111158898 | Lifespan Observations Database (ID: 12) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | ||||||||||||||||||||||||||||||
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1 | OB_008233 |
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2 | The HomoloGene homology group 259 contains 2 genes with experimental evidence for ageing relevance (POU1F1 - Homo sapiens | Pou1f1 - Mus musculus) and 7 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 259 |
Sequences
PIT1_MOUSE | Q00286 | Pituitary-specific positive transcription factor 1 (Mus musculus) from UniProtKB/Swiss-Prot Length: 291 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 PIT1_MOUSE 1 MSCQSFTSADTFITLNSDASAALPLRMHHSAAECLPASNHATNVMSTATGLHYSVPSCHYGNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPLHQPLLAEDPAASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISVAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR 291
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Flurkey K, Papaconstantinou J, Miller RA, Harrison DE:
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production.
Proc Natl Acad Sci USA. 2001; 98: 6736-41.
PubMed (ID: 11371619), PubMed Central (ID: PMC34422), doi:10.1073/pnas.111158898
MeSH Terms: Aging; Collagen/chemistry; DNA-Binding Proteins/genetics; Growth Hormone/physiology; Longevity; T-Lymphocytes/physiology; Transcription Factors/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot