Gene: GSTA4 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | GSTA4 | ||||||||||||||||
NCBI Gene ID | : | 2941 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | glutathione S-alkyltransferase A4 | glutathione S-aralkyltransferase A4 | glutathione S-aryltransferase A4 | GLUTATHIONE S-TRANSFERASE A4 | glutathione S-transferase A4 | glutathione S-transferase A4-4 | glutathione S-transferase alpha 4 | GLUTATHIONE S-TRANSFERASE, ALPHA-4 | glutathione transferase A4-4 | GST class-alpha member 4 | GSTA4 | GSTA4-4 | GTA4 | RP1-214M20.1 | S-(hydroxyalkyl)glutathione lyase A4 Source: GPSDB |
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Gene Homologs | : | GSTA4 (Bos taurus) | GSTA4 (Canis lupus familiaris) | GSTA4 (Homo sapiens) | GSTA4 (Macaca mulatta) | GSTA4 (Pan troglodytes) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000426 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Glutathione S-transferase A4 | Homo sapiens | O15217 (UniProtKB/Swiss-Prot) | GSTA4_HUMAN (UniProtKB/Swiss-Prot) | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). | View |
Glutathione S-transferase | Homo sapiens | Q6P4G1 (UniProtKB/TrEMBL) | Q6P4G1_HUMAN (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009615 | Homo sapiens |
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GSTA4 is part of the glutathione system involved in oxidative protection [0044]. Expression of GSTA4 increases in the aged rat cerebral cortex [0746]. There is no causal evidence, however, linking GSTA4 to ageing in humans or in model organisms. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008174 |
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1 | The HomoloGene homology group 55585 contains 1 gene with experimental evidence for ageing relevance (GSTA4 - Homo sapiens) and 4 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 55585 |
Sequences
GSTA4_HUMAN | O15217 | Glutathione S-transferase A4 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 222 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 GSTA4_HUMAN 1 MAARPKLHYPNGRGRMESVRWVLAAAGVEFDEEFLETKEQLYKLQDGNHLLFQQVPMVEIDGMKLVQTRSILHYIADKHNLFGKNLKERTLIDMYVEGTLDLLELLIMHPFLKPDDQQKEVVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPFLQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP 222
Q6P4G1_HUMAN | Q6P4G1 | Glutathione S-transferase (Homo sapiens) from UniProtKB/TrEMBL Length: 129 10 20 30 40 50 60 70 80 90 100 110 120 Q6P4G1_HUMAN 1 MYVEGTLDLLELLIMHPFLKPDDQQKEVVNMAQKAIIRYFPVFEKILRGHGQSFLVGNQLSLADVILLQTILALEEKIPNILSAFPFLQEYTVKLSNIPTIKRFLEPGSKKKPPPDEIYVRTVYNIFRP 129
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Bonafè M, Barbi C, Storci G, Salvioli S, Capri M, Olivieri F, Valensin S, Monti D, Gonos ES, De Benedictis G, Franceschi C:
What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians.
Exp Gerontol. 2002; 37: 1263-71.
PubMed (ID: 12470840)
MeSH Terms: Neoplasms/genetics - Martínez-Lara E, Siles E, Hernández R, Cañuelo AR, Luisa del Moral M, Jiménez A, Blanco S, López-Ramos JC, Esteban FJ, Pedrosa JA, Peinado MA:
Glutathione S-transferase isoenzymatic response to aging in rat cerebral cortex and cerebellum.
Neurobiol Aging. 2003; 24: 501-9.
PubMed (ID: 12600725)
MeSH Terms: Aging/physiology; Astrocytes/enzymology; Bacterial Proteins; Cerebellum/enzymology; Cerebral Cortex/enzymology; Glutathione Transferase/metabolism; Isoenzymes/metabolism; Oligodendroglia/enzymology - Cho CG, Kim HJ, Chung SW, Jung KJ, Shim KH, Yu BP, Yodoi J, Chung HY:
Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process.
Exp Gerontol. 2003; 38: 539-48.
PubMed (ID: 12742531)
MeSH Terms: Aging/physiology; Caloric Restriction/methods; DNA-(Apurinic or Apyrimidinic Site) Lyase; Drosophila Proteins; Glutathione/metabolism; Thioredoxins/metabolism; Transcription Factors - Kwon YW, Masutani H, Nakamura H, Ishii Y, Yodoi J:
Redox regulation of cell growth and cell death.
Biol Chem. 2003; 384: 991-6.
PubMed (ID: 12956415), doi:10.1515/BC.2003.111
MeSH Terms: Apoptosis/physiology; Cell Cycle; Oxidative Stress/physiology - Brown-Borg HM, Rakoczy SG, Uthus EO:
Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice.
Mech Ageing Dev. 2005; 126: 389-98.
PubMed (ID: 15664625), doi:10.1016/j.mad.2004.09.005
MeSH Terms: Glutathione/metabolism; Growth Hormone/administration & dosage; Longevity/drug effects; Methionine/metabolism; Signal Transduction/drug effects - Brown-Borg HM, Rakoczy SG:
Glutathione metabolism in long-living Ames dwarf mice.
Exp Gerontol. 2005; 40: 115-20.
PubMed (ID: 15664737), doi:10.1016/j.exger.2004.11.004
MeSH Terms: Aging/metabolism; Glutathione/metabolism; Longevity - Ayyadevara S, Engle MR, Singh SP, Dandapat A, Lichti CF, Benes H, Shmookler Reis RJ, Liebau E, Zimniak P:
Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal.
Aging Cell. 2005; 4: 257-71.
PubMed (ID: 16164425), doi:10.1111/j.1474-9726.2005.00168.x
MeSH Terms: Aldehydes/metabolism; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/physiology; Glutathione Transferase/metabolism; Growth Inhibitors/metabolism; Lipid Peroxidation; Longevity - Martínez-Romero R, Cañuelo A, Martínez-Lara E, Hernández R, Del Moral ML, Pedrosa JA, Peinado MA, Siles E:
Aging affects but does not eliminate the enzymatic antioxidative response to hypoxia/reoxygenation in cerebral cortex.
Exp Gerontol. 2006; 41: 25-31.
PubMed (ID: 16260109), doi:10.1016/j.exger.2005.09.009
MeSH Terms: Aging/physiology; Cerebral Cortex/enzymology; Hypoxia, Brain/physiopathology
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL