Gene: TBP - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | TBP | ||||||||||||||||
NCBI Gene ID | : | 6908 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | GTF2D | GTF2D1 | HDL4 | RP1-191N21.3 | SCA17 | SCA17 GENE | TATA box binding protein | TATA BOX-BINDING PROTEIN | TATA sequence-binding protein | TATA-box binding protein N-terminal domain | TATA-box factor | TATA-box-binding protein | TBP | TF2D | TFIID | transcription initiation factor TFIID TBP subunit Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP010958 (Anopheles gambiae) | AGOS_AGR134W (Eremothecium gossypii) | KLLA0E10099g (Kluyveromyces lactis) | MGG_08878 (Magnaporthe oryzae) | NCU04770 (Neurospora crassa) | Os10g0432300 (Oryza sativa) | SPT15 (Saccharomyces cerevisiae) | TBP (Bos taurus) | TBP (Canis lupus familiaris) | tbp (Danio rerio) | Tbp (Drosophila melanogaster) | TBP (Gallus gallus) | TBP (Homo sapiens) | TBP (Macaca mulatta) | Tbp (Mus musculus) | TBP (Pan troglodytes) | Tbp (Rattus norvegicus) | tbp-1 (Caenorhabditis elegans) | tbp1 (Schizosaccharomyces pombe) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000482 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
TATA-box-binding protein | Homo sapiens | F5H869 (UniProtKB/TrEMBL) | F5H869_HUMAN (UniProtKB/TrEMBL) | View | |
TATA box binding protein | Homo sapiens | Q32MN7 (UniProtKB/TrEMBL) | Q32MN7_HUMAN (UniProtKB/TrEMBL) | View | |
TATA-box-binding protein | Homo sapiens | P20226 (UniProtKB/Swiss-Prot) | TBP_HUMAN (UniProtKB/Swiss-Prot) | General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009784 | Homo sapiens |
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TBP is part of the TFIID general transcription factor. Because of its central role in the activation of eukaryotic genes, TBP is potentially involved in a large variety of processes. TBP-null mice die at embryonic stages [0848]. Mutations in the human TBP gene have been associated with neurological diseases [0846]. Although TBP has not been directly linked to human ageing, because it is involved in so many different processes, and potentially in neurodegenerative diseases, it is possible that TBP plays some role in human ageing. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008951 | 2 | The HomoloGene homology group 2404 contains 2 genes with experimental evidence for ageing relevance (TBP - Homo sapiens | tbp-1 - Caenorhabditis elegans) and 17 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 2404 |
Sequences
F5H869_HUMAN | F5H869 | TATA-box-binding protein (Homo sapiens) from UniProtKB/TrEMBL Length: 319 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 F5H869_HUMAN 1 MTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT 319
Q32MN7_HUMAN | Q32MN7 | TATA box binding protein (Homo sapiens) from UniProtKB/TrEMBL Length: 338 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 Q32MN7_HUMAN 1 MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT 338
TBP_HUMAN | P20226 | TATA-box-binding protein (Homo sapiens) from UniProtKB/Swiss-Prot Length: 339 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 TBP_HUMAN 1 MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT 339
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Hisatake K, Hasegawa S, Takada R, Nakatani Y, Horikoshi M, Roeder RG:
The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1.
Nature. 1993; 362: 179-81.
PubMed (ID: 8450888), doi:10.1038/362179a0
MeSH Terms: Cell Cycle/physiology; DNA-Binding Proteins/genetics; Nuclear Proteins/genetics; TATA Box; TATA-Binding Protein Associated Factors; Transcription Factors/genetics - Koide R, Kobayashi S, Shimohata T, Ikeuchi T, Maruyama M, Saito M, Yamada M, Takahashi H, Tsuji S:
A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?
Hum Mol Genet. 1999; 8: 2047-53.
PubMed (ID: 10484774)
MeSH Terms: Ataxia/genetics; Chromosomes, Human, Pair 6/genetics; Cognition Disorders/genetics; DNA-Binding Proteins/genetics; Dwarfism/genetics; Epilepsy, Absence/genetics; Muscle Spasticity/genetics; Peptides/chemistry; Transcription Factors/genetics; Trinucleotide Repeats - Veenstra GJ, Weeks DL, Wolffe AP:
Distinct roles for TBP and TBP-like factor in early embryonic gene transcription in Xenopus.
Science. 2000; 290: 2312-5.
PubMed (ID: 11125147), doi:10.1126/science.290.5500.2312
MeSH Terms: DNA-Binding Proteins/metabolism; Embryo, Nonmammalian/metabolism; Embryonic Development; Gene Expression Regulation, Developmental; Transcription Factors/metabolism; Transcription, Genetic - Zühlke C, Hellenbroich Y, Dalski A, Kononowa N, Hagenah J, Vieregge P, Riess O, Klein C, Schwinger E:
Different types of repeat expansion in the TATA-binding protein gene are associated with a new form of inherited ataxia.
Eur J Hum Genet. 2001; 9: 160-4.
PubMed (ID: 11313753), doi:10.1038/sj.ejhg.5200617
MeSH Terms: Ataxia/genetics; DNA-Binding Proteins/genetics; Transcription Factors/genetics; Trinucleotide Repeats - Hobbs NK, Bondareva AA, Barnett S, Capecchi MR, Schmidt EE:
Removing the vertebrate-specific TBP N terminus disrupts placental beta2m-dependent interactions with the maternal immune system.
Cell. 2002; 110: 43-54.
PubMed (ID: 12150996), PubMed Central (ID: PMC2701386)
MeSH Terms: DNA-Binding Proteins/physiology; Immunity, Maternally-Acquired/immunology; Maternal-Fetal Exchange/immunology; Placenta/immunology; Transcription Factors/physiology; beta 2-Microglobulin/immunology - Martianov I, Viville S, Davidson I:
RNA polymerase II transcription in murine cells lacking the TATA binding protein.
Science. 2002; 298: 1036-9.
PubMed (ID: 12411709), doi:10.1126/science.1076327
MeSH Terms: RNA Polymerase II/metabolism; TATA-Box Binding Protein/physiology; Transcription, Genetic
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL