Gene: YKU70 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | YKU70 | ||||||||||||||||||||||||
NCBI Gene ID | : | 855328 | ||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||
Gene Synonyms | : | HDF1 | KU70 | NES24 | YKU70 | Yku70p | YM8021.10 | YMR284W Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP002690 (Anopheles gambiae) | cku-70 (Caenorhabditis elegans) | Irbp (Drosophila melanogaster) | KLLA0C06226g (Kluyveromyces lactis) | KU70 (Arabidopsis thaliana) | LOC100536337 (Danio rerio) | MGG_01512 (Magnaporthe oryzae) | NCU08290 (Neurospora crassa) | Os07g0184900 (Oryza sativa) | pku70 (Schizosaccharomyces pombe) | XRCC6 (Bos taurus) | XRCC6 (Canis lupus familiaris) | xrcc6 (Danio rerio) | XRCC6 (Gallus gallus) | XRCC6 (Homo sapiens) | XRCC6 (Macaca mulatta) | Xrcc6 (Mus musculus) | XRCC6 (Pan troglodytes) | Xrcc6 (Rattus norvegicus) | YKU70 (Saccharomyces cerevisiae) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000582 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_000513 | Saccharomyces cerevisiae | W303AR5 |
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decreased | -18.40% | 17.3 | 21.2 | mean | 30 | ℃ | mata | Deletion of the Ku homologs HDF1 or HDF2 shortened life span. | Kaeberlein et al. | 1999 | 10521401 | Lifespan Observations Database (ID: 1773) | ||||||||||||||||||
2 | OB_006262 | Saccharomyces cerevisiae |
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decreased | unknown | Mutants had a shorter lifespan. | Kaeberlein et al. | 1999 | 10521401 | GenAge | |||||||||||||||||||||||||
3 | OB_006263 | Saccharomyces cerevisiae |
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decreased | unknown | Mean replicative lifespan decreased in the alpha and a strain | Fabrizio et al. | 2010 | 20657825 | doi:10.1371/journal.pgen.1001024 | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kaeberlein M, McVey M, Guarente L:
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
Genes Dev. 1999; 13: 2570-80.
PubMed (ID: 10521401), PubMed Central (ID: PMC317077)
MeSH Terms: DNA-Binding Proteins/physiology; Fungal Proteins/physiology; Histone Deacetylases; Saccharomyces cerevisiae Proteins; Saccharomyces cerevisiae/physiology; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Trans-Activators/physiology - Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD:
Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.
PLoS Genet. 2010; 6: e1001024.
PubMed (ID: 20657825), PubMed Central (ID: PMC2904796), doi:10.1371/journal.pgen.1001024
MeSH Terms: Genome, Fungal; Longevity/genetics; Saccharomyces cerevisiae/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed