1 |
OB_004187 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
80.90% |
48.3 |
26.7 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of both FOB1 and HXK2 significantly increased life span in the BY4742 background. The double deletion mutant was also significantly longer-lived than either single mutant, consistent with the model that FOB1 and HXK2 act in parallel pathways to modulate replicative life span in yeast. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 876) |
2 |
OB_000117 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HST1 |
Saccharomyces cerevisiae |
854086 |
deletion / null |
- |
unknown |
unknown |
HST2 |
Saccharomyces cerevisiae |
856092 |
deletion / null |
- |
unknown |
unknown |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
70.82% |
43.9 |
25.7 |
|
|
30 |
℃ |
matalpha |
Deletion of HXK2 significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from deletion of HXK2. Deletion of HXK2 is proposed as a genetic mimic of dietary restriction [ 11000115]. |
Kaeberlein et al. |
2006 |
16741098 |
doi:10.1126/science.1124608 |
Lifespan Observations Database (ID: 1127) |
3 |
OB_004198 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
70.57% |
45.2 |
26.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of HXK2 significantly increased the life span of SIR2 FOB1 double mutants in the BY4742. The SIR2 FOB1 HXK2 triple mutant was approximately 70% longer-lived than wild type cells.. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 886) |
4 |
OB_000541 |
Saccharomyces cerevisiae |
PSY316 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
52.75% |
33.3 |
21.8 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of HXK2 increases life span. |
Lin et al. |
2000 |
11000115 |
|
Lifespan Observations Database (ID: 1801) |
5 |
OB_005399 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HXK2 |
Saccharomyces cerevisiae |
852639 |
Deletion |
- |
wildtype |
yes |
|
|
|
increased |
50.00% |
|
|
|
unknown |
|
|
|
Deletion extends lifespan about 50%. |
Lin et al. |
2000 |
11000115 |
|
GenAge |
6 |
OB_004189 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
43.92% |
36.7 |
25.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of both HXK2 significantly increased life span in the BY4742 background. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 878) |
7 |
OB_004186 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
37.45% |
36.7 |
26.7 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of HXK2 significantly increased life span in the BY4742 background. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 875) |
8 |
OB_004182 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
34.00% |
|
25.9 |
|
mean |
|
|
|
The hxk2 deletion from the MATalpha haploid yeast orf deletion collection had a replicative life span that was significantly increased relative to wild type BY4742 cells. |
Kaeberlein et al. |
2005 |
15722108 |
doi:10.1016/j.mad.2004.10.007 |
Lifespan Observations Database (ID: 871) |
9 |
OB_000119 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
24.12% |
31.9 |
25.7 |
|
|
30 |
℃ |
matalpha |
Deletion of HXK2 significantly increases the replicative life span of sir2 fob1 hst1 hst2 quadruple mutant cells in the BY4742 strain background. These data demonstrate that SIR2, HST1, and HST2 are dispensable, both individually and in combination, for life span extension from deletion of HXK2. Deletion of HXK2 is proposed as a genetic mimic of dietary restriction [ 11000115]. |
Kaeberlein et al. |
2006 |
16741098 |
doi:10.1126/science.1124608 |
Lifespan Observations Database (ID: 1129) |
10 |
OB_004195 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HXK2 |
Saccharomyces cerevisiae |
852639 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
decreased |
-53.56% |
12.4 |
26.7 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of both HXK2 and SIR2 significantly decreased life span in the BY4742 background to the same extent as deletion of SIR2 alone. |
Kaeberlein et al. |
2004 |
15328540 |
doi:10.1371/journal.pbio.0020296 |
Lifespan Observations Database (ID: 883) |
11 |
OB_005400 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
HXK2 |
Saccharomyces cerevisiae |
852639 |
Deletion |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
Mean chronological lifespan strongly increased in the a strain |
Matecic et al. |
2010 |
20421943 |
doi:10.1371/journal.pgen.1000921 |
GenAge |