Gene: KCNA3 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | KCNA3 | ||||||||||||||||
NCBI Gene ID | : | 3738 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | HGK5 | HLK3 | HPCN3 | HUKIII | KCNA3 | KV1.3 | Kv1.3 | MK3 | MK3, MOUSE, HOMOLOG OF | PCN3 | POTASSIUM CHANNEL 3 | potassium channel 3 | POTASSIUM CHANNEL, VOLTAGE-GATED, SHAKER-RELATED SUBFAMILY, MEMBER 3 | potassium voltage-gated channel subfamily A member 3 | potassium voltage-gated channel, shaker-related subfamily, member 3 | type n potassium channel | voltage-gated K(+) channel HuKIII | voltage-gated potassium channel protein Kv1.3 | voltage-gated potassium channel subunit Kv1.3 Source: GPSDB |
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Gene Homologs | : | KCNA3 (Bos taurus) | KCNA3 (Canis lupus familiaris) | KCNA3 (Gallus gallus) | KCNA3 (Homo sapiens) | KCNA3 (Macaca mulatta) | Kcna3 (Mus musculus) | KCNA3 (Pan troglodytes) | Kcna3 (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000605 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Potassium voltage-gated channel subfamily A member 3 | Homo sapiens | P22001 (UniProtKB/Swiss-Prot) | KCNA3_HUMAN (UniProtKB/Swiss-Prot) | Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
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1 | OB_009661 | Homo sapiens |
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The potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is involved in the repolarization of nerve cells following an action potential. It also plays an essential role in T-cell proliferation and activation. In the murine model, null mice weigh less than their WT counterparts, have modified ingestive behaviors, are resistant to fat deposition following a moderately high-fat dietary regime and have improved longevity and fecundity. Moreover, gene-targeted deletion in the short-lived MC4R-null mice returned the lifespan of these mice to approximately wild type levels [2163]. A variant in the promoter of the Kv1.3 gene was found associated, in a genome-wide study among nondiabetic, with impaired glucose tolerance and lower insulin sensitivity [2164]. KCNA3 is also involved in age-related diseases, like Alzheimer's Disease and cancer. For example, an aberrant glutamate-dependent modulation of Kv1.3 channels was found in T lymphocytes of AD patients [2165] and it was shown that the inhibition of Kv1.3 has an anti-proliferative effect, blocking proliferation of human lung adenocarcinoma cells [2166]. In breast adenocarcinoma, Kv1.3 gene expression is decreased probably due to DNA methylation, and is associated with poorly differentiated tumors and younger patients [2167]. A reduced expression of Kv1.3 was also found in human prostate cancer [2168]. So far there has been no direct evidence linking KCNA3 to human longevity and further research is needed. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | |||||||||||||||||||||||||||
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1 | OB_008183 |
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2 | The HomoloGene homology group 128570 contains 2 genes with experimental evidence for ageing relevance (KCNA3 - Homo sapiens | Kcna3 - Mus musculus) and 6 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 128570 |
Sequences
KCNA3_HUMAN | P22001 | Potassium voltage-gated channel subfamily A member 3 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 575 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 KCNA3_HUMAN 1 MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV 575
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Tschritter O, Machicao F, Stefan N, Schäfer S, Weigert C, Staiger H, Spieth C, Häring HU, Fritsche A:
A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance.
J Clin Endocrinol Metab. 2006; 91: 654-8.
PubMed (ID: 16317062), doi:10.1210/jc.2005-0725
MeSH Terms: Glucose Intolerance/genetics; Insulin Resistance/genetics; Kv1.3 Potassium Channel/genetics - Abdul M, Hoosein N:
Reduced Kv1.3 potassium channel expression in human prostate cancer.
J Membr Biol. 2006; 214: 99-102.
PubMed (ID: 17546508), doi:10.1007/s00232-006-0065-7
MeSH Terms: Gene Expression Regulation, Neoplastic; Kv1.3 Potassium Channel/biosynthesis; Prostate-Specific Antigen/biosynthesis; Prostatic Hyperplasia/metabolism; Prostatic Neoplasms/metabolism - Tucker K, Overton JM, Fadool DA:
Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice.
Int J Obes (Lond). 2008; 32: 1222-32.
PubMed (ID: 18542083), PubMed Central (ID: PMC2737548), doi:10.1038/ijo.2008.77
MeSH Terms: Adiposity/genetics; Kv1.3 Potassium Channel/genetics; Locomotion/genetics; Longevity/genetics; Receptor, Melanocortin, Type 4/genetics - Brevet M, Haren N, Sevestre H, Merviel P, Ouadid-Ahidouch H:
DNA methylation of K(v)1.3 potassium channel gene promoter is associated with poorly differentiated breast adenocarcinoma.
Cell Physiol Biochem. 2009; 24: 25-32.
PubMed (ID: 19590190), doi:10.1159/000227810
MeSH Terms: Adenocarcinoma/genetics; Breast Neoplasms/genetics; DNA Methylation; Kv1.3 Potassium Channel/genetics; Promoter Regions, Genetic - Poulopoulou C, Markakis I, Davaki P, Tsaltas E, Rombos A, Hatzimanolis A, Vassilopoulos D:
Aberrant modulation of a delayed rectifier potassium channel by glutamate in Alzheimer's disease.
Neurobiol Dis. 2010; 37: 339-48.
PubMed (ID: 19850126), doi:10.1016/j.nbd.2009.10.012
MeSH Terms: Alzheimer Disease/metabolism; Glutamic Acid/metabolism; Kv1.3 Potassium Channel/metabolism; Receptors, Metabotropic Glutamate/metabolism; T-Lymphocytes/metabolism - Jang SH, Choi SY, Ryu PD, Lee SY:
Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo.
Eur J Pharmacol. 2011; 651: 26-32.
PubMed (ID: 21087602), doi:10.1016/j.ejphar.2010.10.066
MeSH Terms: Kv1.3 Potassium Channel/antagonists & inhibitors; Potassium Channel Blockers/pharmacology; RNA, Small Interfering/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot