1 |
OB_000608 |
Saccharomyces cerevisiae |
DBY746 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
200.00% |
27 |
9 |
days |
median |
30 |
℃ |
|
Deletion of SCH9 or inactivating mutations (K441A or D556R) increased chronological life span approximately 3-fold. |
Fabrizio et al. |
2001 |
11292860 |
doi:10.1126/science.1059497 |
Lifespan Observations Database (ID: 1876) |
2 |
OB_000609 |
Saccharomyces cerevisiae |
DBY746 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
loss of function |
K441A |
unknown |
unknown |
|
|
|
increased |
200.00% |
|
|
days |
median |
30 |
℃ |
|
Deletion of SCH9 or inactivating mutations (K441A or D556R) increased chronological life span approximately 3-fold. |
Fabrizio et al. |
2001 |
11292860 |
doi:10.1126/science.1059497 |
Lifespan Observations Database (ID: 1877) |
3 |
OB_000610 |
Saccharomyces cerevisiae |
DBY746 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
loss of function |
D556R |
unknown |
unknown |
|
|
|
increased |
200.00% |
|
|
days |
median |
30 |
℃ |
|
Deletion of SCH9 or inactivating mutations (K441A or D556R) increased chronological life span approximately 3-fold. |
Fabrizio et al. |
2001 |
11292860 |
doi:10.1126/science.1059497 |
Lifespan Observations Database (ID: 1878) |
4 |
OB_005876 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
Mutation |
- |
wildtype |
yes |
|
|
|
increased |
200.00% |
|
|
|
unknown |
|
|
|
More than 3 fold extension of chronological lifespan, by day 9 of medium depletion all the WT yeast were dead while 50% sch9 mutants survived |
Weinberger et al. |
2007 |
17710147 |
doi:10.1371/journal.pone.0000748 |
GenAge |
5 |
OB_000092 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
116.18% |
52.1 |
24.1 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of TOR or SCH9 increase life span additively with deletion of FOB1 but not with dietary restriction. These data support the model that TOR, SCH9 and dietary restriction act in a single pathway that is distinct from the pathway that FOB1 acts in. Deletion of FOB1 is believed to increase replicative life span by reducing the accumulation of extrachromosomal rDNA circles (ERCs) in the mother cell [10207108]. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1091) |
6 |
OB_000295 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
49.59% |
36.2 |
24.2 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of GCN4 prevents maximal life span extension from deletion of TOR1, deletion of SCH9, or dietary restriction. From Supplemental Figure 6. |
Steffen et al. |
2008 |
18423200 |
doi:10.1016/j.cell.2008.02.037 |
Lifespan Observations Database (ID: 1299) |
7 |
OB_000095 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
49.39% |
36.6 |
24.5 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [ 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [ 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1094) |
8 |
OB_000087 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
41.86% |
36.6 |
25.8 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of SCH9 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that SCH9 and dietary restriction act in the same pathway to promote longevity. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1087) |
9 |
OB_000190 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
40.00% |
|
|
divisions |
mean |
30 |
℃ |
matalpha |
From Table 2. Conserved longevity genes. 25 replicative life span extending single-gene deletions in the BY4742 strain background were identified that correspond to known aging-related genes in Caenorhabditis elegans. |
Smith et al. |
2008 |
18340043 |
doi:10.1101/gr.074724.107 |
Lifespan Observations Database (ID: 1199) |
10 |
OB_005877 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
Deletion |
- |
wildtype |
yes |
|
|
|
increased |
40.00% |
|
|
|
unknown |
|
|
|
Replicative lifespan increased by 40% in the alpha strain |
Smith et al. |
2008 |
18340043 |
doi:10.1101/gr.074724.107 |
GenAge |
11 |
OB_000294 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
GCN4 |
Saccharomyces cerevisiae |
856709 |
deletion / null |
- |
unknown |
unknown |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
38.84% |
33.6 |
24.2 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of GCN4 prevents maximal life span extension from deletion of TOR1, deletion of SCH9, or dietary restriction. From Supplemental Figure 6. |
Steffen et al. |
2008 |
18423200 |
doi:10.1016/j.cell.2008.02.037 |
Lifespan Observations Database (ID: 1298) |
12 |
OB_004181 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
|
increased |
38.00% |
|
26.9 |
|
mean |
|
|
|
A deletion of SCH9 with a URA3 marker had no significant effect on replicative life span in the BY4742 deletion set background. There is no SCH9 deletion in the yeast ORF deletion collection. |
Kaeberlein et al. |
2005 |
15722108 |
doi:10.1016/j.mad.2004.10.007 |
Lifespan Observations Database (ID: 870) |
13 |
OB_001778 |
Saccharomyces cerevisiae |
DBY746 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
non-null recessive |
mTn |
unknown |
unknown |
|
|
|
increased |
33.33% |
12 |
9 |
days |
mean |
30 |
℃ |
|
Disruption of SCH9 extends chronological life span, as measured by stationary phase survival, up to 300%. Other phenotypes: Deletion of SOD2 prevents the increased stationary phase survival caused by mutation of SCH9. [ 12882320]. Deletion of SCH9 also increases restistance to heat shock and oxidative stress [ 11292860] and increases replcative life-span by 18% [ 14741356]. |
Fabrizio et al. |
2001 |
11292860 |
doi:10.1126/science.1059497 |
Lifespan Observations Database (ID: 30) |
14 |
OB_000086 |
Saccharomyces cerevisiae |
BY4742 |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
increased |
15.50% |
29.8 |
25.8 |
divisions |
mean |
30 |
℃ |
matalpha |
Deletion of SCH9 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that SCH9 and dietary restriction act in the same pathway to promote longevity. |
Kaeberlein et al. |
2005 |
16293764 |
doi:10.1126/science.1115535 |
Lifespan Observations Database (ID: 1086) |
15 |
OB_005875 |
Saccharomyces cerevisiae |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
Deletion |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
The deletion of SCH9, which encodes for a serine threonine kinase, triples the mean life span and increases resistance to oxidative and thermal stress. Mutations that decrease the activity of the Ras/Cyr1/PKA pathway also extend longevity and increase stress resistance by activating transcription factors Msn2/Msn4 and the mitochondrial antioxidant enzyme superoxide dismutase (Sod2). |
Longo |
2003 |
12855292 |
|
GenAge |