Gene: NACA - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | NACA | ||||||||||||
NCBI Gene ID | : | 4666 | ||||||||||||
Species | : | Homo sapiens | ||||||||||||
Gene Synonyms | : | alpha-NAC | HSD48 | NAC-alpha | NACA | NACA1 | nascent polypeptide-associated complex alpha subunit | nascent polypeptide-associated complex subunit alpha | NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX, ALPHA POLYPEPTIDE | nascent-polypeptide-associated complex alpha polypeptide Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP006766 (Anopheles gambiae) | AGOS_AER168C (Eremothecium gossypii) | AT3G49470.1 (Arabidopsis thaliana) | EGD2 (Saccharomyces cerevisiae) | egd2 (Schizosaccharomyces pombe) | KLLA0B04290g (Kluyveromyces lactis) | MGG_02660 (Magnaporthe oryzae) | NACA (Bos taurus) | NACA (Canis lupus familiaris) | NACA (Gallus gallus) | NACA (Homo sapiens) | NACA (Pan troglodytes) | Nacalpha (Drosophila melanogaster) | NCU00635 (Neurospora crassa) | Os01g0698900 (Oryza sativa) | Os03g0121700 (Oryza sativa) | Y65B4BR.5 (Caenorhabditis elegans) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000652 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
HCG2016482, isoform CRA_b | Homo sapiens | B2R4P8 (UniProtKB/TrEMBL) | B2R4P8_HUMAN (UniProtKB/TrEMBL) | View | |
Nascent polypeptide-associated complex subunit alpha | Homo sapiens | F8VU71 (UniProtKB/TrEMBL) | F8VU71_HUMAN (UniProtKB/TrEMBL) | View | |
Nascent polypeptide-associated complex subunit alpha | Homo sapiens | Q13765 (UniProtKB/Swiss-Prot) | NACA_HUMAN (UniProtKB/Swiss-Prot) | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008227 | 2 | The HomoloGene homology group 123861 contains 2 genes with experimental evidence for ageing relevance (EGD2 - Saccharomyces cerevisiae | Y65B4BR.5 - Caenorhabditis elegans) and 15 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 123861 |
Sequences
B2R4P8_HUMAN | B2R4P8 | HCG2016482, isoform CRA_b (Homo sapiens) from UniProtKB/TrEMBL Length: 215 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 B2R4P8_HUMAN 1 MPGEATETVPATEQELPQPQAETGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM 215
F8VU71_HUMAN | F8VU71 | Nascent polypeptide-associated complex subunit alpha (Homo sapiens) from UniProtKB/TrEMBL Length: 925 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 F8VU71_HUMAN 1 MPGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIVAAFPLESADPAGVAPTTAKAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM 925
NACA_HUMAN | Q13765 | Nascent polypeptide-associated complex subunit alpha (Homo sapiens) from UniProtKB/Swiss-Prot Length: 215 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 NACA_HUMAN 1 MPGEATETVPATEQELPQPQAETGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM 215
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL