Gene: HSP104 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | HSP104 | ||||||||||||||||||||||||||||
NCBI Gene ID | : | 850633 | ||||||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||
Gene Synonyms | : | chaperone ATPase HSP104 | HSP104 | Hsp104p | L0948 | YLL026W Source: GPSDB |
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Gene Homologs | : | AGOS_AGL036C (Eremothecium gossypii) | CLPB1 (Arabidopsis thaliana) | HSP104 (Saccharomyces cerevisiae) | hsp104 (Schizosaccharomyces pombe) | KLLA0F18194g (Kluyveromyces lactis) | MGG_06459 (Magnaporthe oryzae) | NCU00104 (Neurospora crassa) | Os05g0519700 (Oryza sativa) | ||||||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000659 | ||||||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_004163 | Saccharomyces cerevisiae | BY4742 |
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increased | 7.00% | 30.4 | mean | 30 | ℃ | The hsp104 deletion from the MATalpha haploid yeast orf deletion collection had a replicative life span that was not significantly different (p=0.3) from wild type BY4742 cells. | Kaeberlein et al. | 2005 | 15722108 | doi:10.1016/j.mad.2004.10.007 | Lifespan Observations Database (ID: 854) | |||||||||||||||||||
2 | OB_005382 | Saccharomyces cerevisiae |
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decreased | -40.00% | unknown | A 40% reduction in replicative lifespan was observed in knockouts. Overexpression had no effect on replicative lifespan but suppressed the reduced lifespan of Sir2-deficient cells. | Erjavec et al. | 2007 | 17908928 | doi:10.1101/gad.439307 | GenAge | |||||||||||||||||||||||
3 | OB_003821 | Saccharomyces cerevisiae |
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none | Overexpression had no effect on replicative lifespan. | Erjavec et al. | 2007 | 17908928 | doi:10.1101/gad.439307 | Lifespan Observations Database (ID: 544) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_008242 | 1 | The HomoloGene homology group 6426 contains 1 gene with experimental evidence for ageing relevance (HSP104 - Saccharomyces cerevisiae) and 7 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 6426 |
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kaeberlein M, Kirkland KT, Fields S, Kennedy BK:
Genes determining yeast replicative life span in a long-lived genetic background.
Mech Ageing Dev. 2005; 126: 491-504.
PubMed (ID: 15722108), doi:10.1016/j.mad.2004.10.007
MeSH Terms: Cell Aging/genetics; Gene Expression Regulation, Fungal/genetics; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae/genetics - Erjavec N, Larsson L, Grantham J, Nyström T:
Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p.
Genes Dev. 2007; 21: 2410-21.
PubMed (ID: 17908928), PubMed Central (ID: PMC1993872), doi:10.1101/gad.439307
MeSH Terms: Heat-Shock Proteins/metabolism; Histone Deacetylases/genetics; Oxidative Stress/drug effects; Saccharomyces cerevisiae Proteins/metabolism; Saccharomyces cerevisiae/growth & development; Silent Information Regulator Proteins, Saccharomyces cerevisiae/genetics; Sirtuins/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed