Gene: SOD2 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | SOD2 | ||||||||||||||||
NCBI Gene ID | : | 6648 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | INDOPHENOL OXIDASE B | indophenoloxidase B | IPO-B | IPOB | MANGANESE SUPEROXIDE DISMUTASE | manganese-containing superoxide dismutase | mangano-superoxide dismutase | Mn superoxide dismutase | MNSOD | MVCD6 | RP1-56L9.2 | SOD2 | SUPEROXIDE DISMUTASE 2 | superoxide dismutase 2, mitochondrial | superoxide dismutase [Mn], mitochondrial | SUPEROXIDE DISMUTASE, MITOCHONDRIAL Source: GPSDB |
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Gene Homologs | : | KLLA0E03609g (Kluyveromyces lactis) | MGG_00212 (Magnaporthe oryzae) | MNSOD1 (Anopheles gambiae) | NCU09560 (Neurospora crassa) | Os05g0323900 (Oryza sativa) | sod-2 (Caenorhabditis elegans) | sod-3 (Caenorhabditis elegans) | SOD2 (Bos taurus) | SOD2 (Canis lupus familiaris) | sod2 (Danio rerio) | Sod2 (Drosophila melanogaster) | SOD2 (Gallus gallus) | SOD2 (Homo sapiens) | SOD2 (Macaca mulatta) | Sod2 (Mus musculus) | SOD2 (Pan troglodytes) | Sod2 (Rattus norvegicus) | SOD2 (Saccharomyces cerevisiae) | sod2 (Schizosaccharomyces pombe) | SODA (Arabidopsis thaliana) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000772 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Superoxide dismutase [Mn], mitochondrial | Homo sapiens | P04179 (UniProtKB/Swiss-Prot) | SODM_HUMAN (UniProtKB/Swiss-Prot) | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009771 | Homo sapiens |
|
SOD2 is an antioxidant, the mitochondrial form of SOD and an important defence against oxidative damage. Evidence from invertebrates suggests it may play a role in ageing. Overexpression of SOD2 in flies significantly extends lifespan [1239]. Mice without SOD2 are not viable [0658]. Reducing the activity of SOD2 in mice increases the levels of oxidative damage to DNA but does not affect lifespan [0655]. SOD2 overexpression in mice slightly increases lifespan [1939], while gene deletion in connective tissue only resulted in mutant mice with a reduced lifespan and premature onset of aging-related phenotypes such as weight loss, skin atrophy, kyphosis, osteoporosis and muscle degeneration [1965]. In the long-lived alphaMUPA mice strain, a reduced level of SOD2 gene expression and activity, was observed together with a maintaining capacity to produce high levels of SOD2 in response to the inflammatory stimulus [1561]. Polymorphisms in the human SOD2 gene have been associated with type 2 diabetes [0661] and cardiomyopathy [1693]. A longevity-associated polymorphism was observed for Ashkenazi males [1350], but not for Italian [2139] and Jordanian [2140] populations. Although it is possible that SOD2 plays a role in human ageing, further studies are needed to investigate this hypothesis. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
SODM_HUMAN | P04179 | Superoxide dismutase [Mn], mitochondrial (Homo sapiens) from UniProtKB/Swiss-Prot Length: 222 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 SODM_HUMAN 1 MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK 222
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ:
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase.
Nat Genet. 1995; 11: 376-81.
PubMed (ID: 7493016), doi:10.1038/ng1295-376
MeSH Terms: Cardiomyopathy, Dilated/enzymology; Mitochondria, Heart/enzymology; Mitochondria, Muscle/enzymology; Superoxide Dismutase/metabolism - Kokoszka JE, Coskun P, Esposito LA, Wallace DC:
Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis.
Proc Natl Acad Sci USA. 2001; 98: 2278-83.
PubMed (ID: 11226230), PubMed Central (ID: PMC30129), doi:10.1073/pnas.051627098
MeSH Terms: Aging/physiology; Apoptosis; Mitochondria, Liver/metabolism; Oxidative Stress; Superoxide Dismutase/genetics - Hall DM, Sattler GL, Sattler CA, Zhang HJ, Oberley LW, Pitot HC, Kregel KC:
Aging lowers steady-state antioxidant enzyme and stress protein expression in primary hepatocytes.
J Gerontol A Biol Sci Med Sci. 2001; 56: B259-67.
PubMed (ID: 11382788)
MeSH Terms: Aging/metabolism; HSP70 Heat-Shock Proteins/metabolism; Hepatocytes/metabolism; Homeostasis/physiology; Oxidoreductases/metabolism - Van Remmen H, Williams MD, Guo Z, Estlack L, Yang H, Carlson EJ, Epstein CJ, Huang TT, Richardson A:
Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis.
Am J Physiol Heart Circ Physiol. 2001; 281: H1422-32.
PubMed (ID: 11514315)
MeSH Terms: Apoptosis; Heterozygote; Mitochondria, Heart/enzymology; Superoxide Dismutase/genetics; Superoxide Dismutase/metabolism - Sreekumar R, Unnikrishnan J, Fu A, Nygren J, Short KR, Schimke J, Barazzoni R, Nair KS:
Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle.
Am J Physiol Endocrinol Metab. 2002; 283: E38-43.
PubMed (ID: 12067840), doi:10.1152/ajpendo.00387.2001
MeSH Terms: Energy Intake/physiology; Membrane Transport Proteins; Mitochondria/genetics; Mitochondria/metabolism; Mitochondrial Proteins; Muscle, Skeletal/metabolism; RNA, Messenger/metabolism - Sun J, Folk D, Bradley TJ, Tower J:
Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster.
Genetics. 2002; 161: 661-72.
PubMed (ID: 12072463), PubMed Central (ID: PMC1462135)
MeSH Terms: Drosophila melanogaster/physiology; Longevity; Mitochondria/enzymology; Superoxide Dismutase/genetics - Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM:
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.
Nature. 2002; 419: 316-21.
PubMed (ID: 12239572), doi:10.1038/nature01036
MeSH Terms: DNA-Binding Proteins/metabolism; Oxidative Stress; Protein-Serine-Threonine Kinases; Superoxide Dismutase/biosynthesis; Superoxide Dismutase/genetics; Transcription Factors/metabolism - Kirby K, Hu J, Hilliker AJ, Phillips JP:
RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress.
Proc Natl Acad Sci USA. 2002; 99: 16162-7.
PubMed (ID: 12456885), PubMed Central (ID: PMC138582), doi:10.1073/pnas.252342899
MeSH Terms: Drosophila Proteins/deficiency; Drosophila melanogaster/enzymology; Mitochondria/enzymology; RNA Interference; Superoxide Dismutase/deficiency - Nomiyama T, Tanaka Y, Piao L, Nagasaka K, Sakai K, Ogihara T, Nakajima K, Watada H, Kawamori R:
The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients.
J Hum Genet. 2003; 48: 138-41.
PubMed (ID: 12624725), doi:10.1007/s100380300021
MeSH Terms: Diabetes Mellitus, Type 2/complications; Diabetes Mellitus, Type 2/genetics; Diabetic Nephropathies/genetics; Superoxide Dismutase/genetics - Orr WC, Mockett RJ, Benes JJ, Sohal RS:
Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster.
J Biol Chem. 2003; 278: 26418-22.
PubMed (ID: 12743125), doi:10.1074/jbc.M303095200
MeSH Terms: Catalase/genetics; Drosophila melanogaster/enzymology; Drosophila melanogaster/genetics; Longevity/genetics; Longevity/physiology; Superoxide Dismutase/genetics; Thioredoxin-Disulfide Reductase/genetics - Liu R, Liu IY, Bi X, Thompson RF, Doctrow SR, Malfroy B, Baudry M:
Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics.
Proc Natl Acad Sci USA. 2003; 100: 8526-31.
PubMed (ID: 12815103), PubMed Central (ID: PMC166262), doi:10.1073/pnas.1332809100
MeSH Terms: Aging/psychology; Antioxidants/therapeutic use; Brain/metabolism; Learning Disorders/drug therapy; Memory Disorders/drug therapy; Organometallic Compounds/therapeutic use; Salicylates/therapeutic use - Allen RG, Keogh BP, Gerhard GS, Pignolo R, Horton J, Cristofalo VJ:
Expression and regulation of superoxide dismutase activity in human skin fibroblasts from donors of different ages.
J Cell Physiol. 1995; 165: 576-87.
PubMed (ID: 7593237), doi:10.1002/jcp.1041650316
MeSH Terms: Skin/enzymology; Superoxide Dismutase/metabolism - Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ, Huang TT, Nelson J, Strong R, Richardson A:
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging.
Physiol Genomics. 2003; 16: 29-37.
PubMed (ID: 14679299), doi:10.1152/physiolgenomics.00122.2003
MeSH Terms: Aging/genetics; Aging/physiology; DNA Damage; Neoplasms/enzymology; Neoplasms/genetics; Superoxide Dismutase/deficiency; Superoxide Dismutase/metabolism - Liang LP, Patel M:
Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice.
Free Radic Biol Med. 2004; 36: 542-54.
PubMed (ID: 14980699), doi:10.1016/j.freeradbiomed.2003.11.029
MeSH Terms: Epilepsy/metabolism; Mitochondria/metabolism; Neurodegenerative Diseases/metabolism; Oxidative Stress; Seizures/metabolism - Hussain SP, Amstad P, He P, Robles A, Lupold S, Kaneko I, Ichimiya M, Sengupta S, Mechanic L, Okamura S, Hofseth LJ, Moake M, Nagashima M, Forrester KS, Harris CC:
p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.
Cancer Res. 2004; 64: 2350-6.
PubMed (ID: 15059885)
MeSH Terms: Apoptosis/physiology; Glutathione Peroxidase/biosynthesis; Superoxide Dismutase/biosynthesis; Tumor Suppressor Protein p53/physiology - Sun J, Molitor J, Tower J:
Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span.
Mech Ageing Dev. 2004; 125: 341-9.
PubMed (ID: 15130751), doi:10.1016/j.mad.2004.01.009
MeSH Terms: Drosophila melanogaster/physiology; Gene Expression Regulation, Enzymologic/genetics; Longevity/genetics; Superoxide Dismutase/genetics; Transgenes/genetics - Martin FM, Friedman JS:
Ticking fast or ticking slow, through Shc must you go?
Sci Aging Knowledge Environ. 2004; 2004: pe32.
PubMed (ID: 15308771), doi:10.1126/sageke.2004.32.pe32
MeSH Terms: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport/physiology; Aging/physiology - Fabrizio P, Battistella L, Vardavas R, Gattazzo C, Liou LL, Diaspro A, Dossen JW, Gralla EB, Longo VD:
Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae.
J Cell Biol. 2004; 166: 1055-67.
PubMed (ID: 15452146), PubMed Central (ID: PMC2172019), doi:10.1083/jcb.200404002
MeSH Terms: Adaptation, Physiological/genetics; Aging/metabolism; Saccharomyces cerevisiae/metabolism; Superoxides/metabolism - Stessman J, Maaravi Y, Hammerman-Rozenberg R, Cohen A, Nemanov L, Gritsenko I, Gruberman N, Ebstein RP:
Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study.
Mech Ageing Dev. 2005; 126: 333-9.
PubMed (ID: 15621215), doi:10.1016/j.mad.2004.08.025
MeSH Terms: Aging/genetics; Longevity/genetics; Polymorphism, Genetic - Landis GN, Tower J:
Superoxide dismutase evolution and life span regulation.
Mech Ageing Dev. 2005; 126: 365-79.
PubMed (ID: 15664623), doi:10.1016/j.mad.2004.08.012
MeSH Terms: Evolution, Molecular; Longevity/physiology; Superoxide Dismutase/metabolism - Taufer M, Peres A, de Andrade VM, de Oliveira G, Sá G, do Canto ME, dos Santos AR, Bauer ME, da Cruz IB:
Is the Val16Ala manganese superoxide dismutase polymorphism associated with the aging process?
J Gerontol A Biol Sci Med Sci. 2005; 60: 432-8.
PubMed (ID: 15933380)
MeSH Terms: Aging/genetics; Alanine/genetics; Free Radical Scavengers/metabolism; Polymorphism, Genetic/genetics; Superoxide Dismutase/genetics; Valine/genetics - Bayne AC, Mockett RJ, Orr WC, Sohal RS:
Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila.
Biochem J. 2005; 391: 277-84.
PubMed (ID: 15954861), PubMed Central (ID: PMC1276925), doi:10.1042/BJ20041872
MeSH Terms: Aging/metabolism; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; Hydrogen Peroxide/metabolism; Longevity/physiology; Mitochondria/metabolism; Superoxides/metabolism - Lebovitz RM, Zhang H, Vogel H, Cartwright J, Dionne L, Lu N, Huang S, Matzuk MM:
Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.
Proc Natl Acad Sci USA. 1996; 93: 9782-7.
PubMed (ID: 8790408), PubMed Central (ID: PMC38506)
MeSH Terms: Cardiomyopathies/enzymology; Mitochondria/enzymology; Nervous System Diseases/enzymology; Superoxide Dismutase/deficiency - Wolf N, Penn P, Pendergrass W, Van Remmen H, Bartke A, Rabinovitch P, Martin GM:
Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence.
Exp Eye Res. 2005; 81: 276-85.
PubMed (ID: 16129095), doi:10.1016/j.exer.2005.01.024
MeSH Terms: Aging/pathology; Cataract/physiopathology; Oxidative Stress - Tirosh O, Pardo M, Schwartz B, Miskin R:
Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine.
Mech Ageing Dev. 2005; 126: 1262-73.
PubMed (ID: 16139868), doi:10.1016/j.mad.2005.07.003
MeSH Terms: Apoptosis; Genetic Predisposition to Disease; Neoplasms/chemically induced; Neoplasms/genetics; Superoxide Dismutase/genetics - Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A, Kurosu H, Miyoshi M, Ogawa Y, Castrillon DH, Rosenblatt KP, Kuro-o M:
Regulation of oxidative stress by the anti-aging hormone klotho.
J Biol Chem. 2005; 280: 38029-34.
PubMed (ID: 16186101), PubMed Central (ID: PMC2515369), doi:10.1074/jbc.M509039200
MeSH Terms: Membrane Proteins/genetics; Membrane Proteins/metabolism; Oxidative Stress - Marzani B, Felzani G, Bellomo RG, Vecchiet J, Marzatico F:
Human muscle aging: ROS-mediated alterations in rectus abdominis and vastus lateralis muscles.
Exp Gerontol. 2005; 40: 959-65.
PubMed (ID: 16213688), doi:10.1016/j.exger.2005.08.010
MeSH Terms: Aging/physiology; Muscle, Skeletal/physiology; Reactive Oxygen Species/metabolism - Silva JP, Shabalina IG, Dufour E, Petrovic N, Backlund EC, Hultenby K, Wibom R, Nedergaard J, Cannon B, Larsson NG:
SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity.
EMBO J. 2005; 24: 4061-70.
PubMed (ID: 16281056), PubMed Central (ID: PMC1356306), doi:10.1038/sj.emboj.7600866
MeSH Terms: Carrier Proteins/metabolism; Membrane Proteins/metabolism; Mitochondria/enzymology; Superoxide Dismutase/genetics; Uncoupling Agents/metabolism - Greer EL, Brunet A:
FOXO transcription factors at the interface between longevity and tumor suppression.
Oncogene. 2005; 24: 7410-25.
PubMed (ID: 16288288), doi:10.1038/sj.onc.1209086
MeSH Terms: Aging/physiology; Cell Transformation, Neoplastic; Forkhead Transcription Factors/physiology; Gene Expression Regulation - Siqueira IR, Fochesatto C, de Andrade A, Santos M, Hagen M, Bello-Klein A, Netto CA:
Total antioxidant capacity is impaired in different structures from aged rat brain.
Int J Dev Neurosci. 2005; 23: 663-71.
PubMed (ID: 16298100), doi:10.1016/j.ijdevneu.2005.03.001
MeSH Terms: Aging/metabolism; Brain Chemistry; Brain/metabolism; Catalase/metabolism; Chromans/metabolism; Glutathione Peroxidase/metabolism; Superoxide Dismutase/metabolism - Kakarla P, Vadluri G, Reddy KS, Leeuwenburgh C:
Vulnerability of the mid aged rat myocardium to the age-induced oxidative stress: influence of exercise training on antioxidant defense system.
Free Radic Res. 2005; 39: 1211-7.
PubMed (ID: 16298747), doi:10.1080/10715760500315118
MeSH Terms: Aging; Antioxidants/metabolism; Myocardium/pathology; Oxidative Stress - Martínez-Romero R, Cañuelo A, Martínez-Lara E, Hernández R, Del Moral ML, Pedrosa JA, Peinado MA, Siles E:
Aging affects but does not eliminate the enzymatic antioxidative response to hypoxia/reoxygenation in cerebral cortex.
Exp Gerontol. 2006; 41: 25-31.
PubMed (ID: 16260109), doi:10.1016/j.exger.2005.09.009
MeSH Terms: Aging/physiology; Cerebral Cortex/enzymology; Hypoxia, Brain/physiopathology - Son TG, Zou Y, Jung KJ, Yu BP, Ishigami A, Maruyama N, Lee J:
SMP30 deficiency causes increased oxidative stress in brain.
Mech Ageing Dev. 2006; 127: 451-7.
PubMed (ID: 16500693), doi:10.1016/j.mad.2006.01.005
MeSH Terms: Calcium-Binding Proteins/deficiency; Calcium-Binding Proteins/physiology; Oxidative Stress - Melov S, Schneider JA, Day BJ, Hinerfeld D, Coskun P, Mirra SS, Crapo JD, Wallace DC:
A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase.
Nat Genet. 1998; 18: 159-63.
PubMed (ID: 9462746), doi:10.1038/ng0298-159
MeSH Terms: DNA, Mitochondrial/genetics; Metalloporphyrins/pharmacology; Neurodegenerative Diseases/genetics; Superoxide Dismutase/deficiency; Superoxide Dismutase/genetics - Alvarez-García O, Vega-Naredo I, Sierra V, Caballero B, Tomás-Zapico C, Camins A, García JJ, Pallàs M, Coto-Montes A:
Elevated oxidative stress in the brain of senescence-accelerated mice at 5 months of age.
Biogerontology. 2006; 7: 43-52.
PubMed (ID: 16518719), doi:10.1007/s10522-005-6041-2
MeSH Terms: Aging/metabolism; Brain/metabolism - Sinitsyna O, Krysanova Z, Ishchenko A, Dikalova AE, Stolyarov S, Kolosova N, Vasunina E, Nevinsky G:
Age-associated changes in oxidative damage and the activity of antioxidant enzymes in rats with inherited overgeneration of free radicals.
J Cell Mol Med. 2006; 10: 206-15.
PubMed (ID: 16563232)
MeSH Terms: Aging; Antioxidants/pharmacology; DNA Damage; Free Radicals/metabolism; Hepatocytes/enzymology; Oxidative Stress - Ehrenbrink G, Hakenhaar FS, Salomon TB, Petrucci AP, Sandri MR, Benfato MS:
Antioxidant enzymes activities and protein damage in rat brain of both sexes.
Exp Gerontol. 2006; 41: 368-71.
PubMed (ID: 16581216), doi:10.1016/j.exger.2006.02.007
MeSH Terms: Aging/physiology; Antioxidants/metabolism; Brain/enzymology; Reproduction/physiology - Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L:
Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.
J Neurosci. 2006; 26: 5167-79.
PubMed (ID: 16687508), doi:10.1523/JNEUROSCI.0482-06.2006
MeSH Terms: Alzheimer Disease/physiopathology; Amyloid beta-Protein Precursor/metabolism; Mental Disorders/physiopathology; Mitochondria/enzymology; Receptors, Cell Surface/metabolism; Superoxide Dismutase/metabolism - Hu D, Cao P, Thiels E, Chu CT, Wu GY, Oury TD, Klann E:
Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase.
Neurobiol Learn Mem. 2007; 87: 372-84.
PubMed (ID: 17129739), PubMed Central (ID: PMC1847321), doi:10.1016/j.nlm.2006.10.003
MeSH Terms: Hippocampus/enzymology; Long-Term Potentiation/physiology; Longevity/physiology; Memory/physiology; Superoxide Dismutase/metabolism - Bonawitz ND, Chatenay-Lapointe M, Pan Y, Shadel GS:
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression.
Cell Metab. 2007; 5: 265-77.
PubMed (ID: 17403371), PubMed Central (ID: PMC3460550), doi:10.1016/j.cmet.2007.02.009
MeSH Terms: Gene Expression Regulation, Fungal; Longevity/genetics; Mitochondria/genetics; Phosphatidylinositol 3-Kinases/physiology; Phosphotransferases (Alcohol Group Acceptor)/physiology; Saccharomyces cerevisiae Proteins/physiology - Taguchi A, Wartschow LM, White MF:
Brain IRS2 signaling coordinates life span and nutrient homeostasis.
Science. 2007; 317: 369-72.
PubMed (ID: 17641201), doi:10.1126/science.1142179
MeSH Terms: Brain/metabolism; Glucose/metabolism; Homeostasis; Intracellular Signaling Peptides and Proteins/metabolism; Longevity; Phosphoproteins/metabolism; Signal Transduction - Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH:
Sirt1 protects against high-fat diet-induced metabolic damage.
Proc Natl Acad Sci USA. 2008; 105: 9793-8.
PubMed (ID: 18599449), PubMed Central (ID: PMC2474520), doi:10.1073/pnas.0802917105
MeSH Terms: Dietary Fats/adverse effects; Metabolism; Nuclear Respiratory Factor 1/genetics; Sirtuins/physiology; Superoxide Dismutase/genetics - Van Raamsdonk JM, Hekimi S:
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.
PLoS Genet. 2009; 5: e1000361.
PubMed (ID: 19197346), PubMed Central (ID: PMC2628729), doi:10.1371/journal.pgen.1000361
MeSH Terms: Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/enzymology; Longevity/genetics; Mitochondria/enzymology; Sequence Deletion; Superoxide Dismutase/genetics - Soerensen M, Christensen K, Stevnsner T, Christiansen L:
The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old.
Mech Ageing Dev. 2009; 130: 308-14.
PubMed (ID: 19428448), PubMed Central (ID: PMC2720516), doi:10.1016/j.mad.2009.01.005
MeSH Terms: Glutathione Peroxidase/genetics; Longevity/genetics; Polymorphism, Single Nucleotide; Superoxide Dismutase/genetics - Williams MD, Van Remmen H, Conrad CC, Huang TT, Epstein CJ, Richardson A:
Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice.
J Biol Chem. 1998; 273: 28510-5.
PubMed (ID: 9774481)
MeSH Terms: Heterozygote; Mitochondria, Liver/metabolism; Oxidative Stress/physiology; Superoxide Dismutase/genetics - Jang YC, Pérez VI, Song W, Lustgarten MS, Salmon AB, Mele J, Qi W, Liu Y, Liang H, Chaudhuri A, Ikeno Y, Epstein CJ, Van Remmen H, Richardson A:
Overexpression of Mn superoxide dismutase does not increase life span in mice.
J Gerontol A Biol Sci Med Sci. 2009; 64: 1114-25.
PubMed (ID: 19633237), PubMed Central (ID: PMC2759571), doi:10.1093/gerona/glp100
MeSH Terms: Aging/metabolism; Superoxide Dismutase/physiology - Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE:
Insulin resistance is a cellular antioxidant defense mechanism.
Proc Natl Acad Sci USA. 2009; 106: 17787-92.
PubMed (ID: 19805130), PubMed Central (ID: PMC2764908), doi:10.1073/pnas.0902380106
MeSH Terms: Antioxidants/metabolism; Insulin Resistance/physiology - Khabour OF, Abdelhalim ES, Abu-Wardeh A:
Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population.
BMC Geriatr. 2009; 9: 57.
PubMed (ID: 20003469), PubMed Central (ID: PMC2801492), doi:10.1186/1471-2318-9-57
MeSH Terms: Arabs/genetics; Longevity/genetics; Methylenetetrahydrofolate Reductase (NADPH2)/genetics; Polymorphism, Single Nucleotide/genetics; Superoxide Dismutase/genetics - Treiber N, Maity P, Singh K, Kohn M, Keist AF, Ferchiu F, Sante L, Frese S, Bloch W, Kreppel F, Kochanek S, Sindrilaru A, Iben S, Högel J, Ohnmacht M, Claes LE, Ignatius A, Chung JH, Lee MJ, Kamenisch Y, Berneburg M, Nikolaus T, Braunstein K, Sperfeld AD, Ludolph AC, Briviba K, Wlaschek M, Florin L, Angel P, Scharffetter-Kochanek K:
Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue.
Aging Cell. 2011; 10: 239-54.
PubMed (ID: 21108731), doi:10.1111/j.1474-9726.2010.00658.x
MeSH Terms: Aging/physiology; Connective Tissue/enzymology; Longevity/physiology; Mitochondria/enzymology; Phenotype; Superoxide Dismutase/deficiency - De Benedictis G, Carotenuto L, Carrieri G, De Luca M, Falcone E, Rose G, Cavalcanti S, Corsonello F, Feraco E, Baggio G, Bertolini S, Mari D, Mattace R, Yashin AI, Bonafè M, Franceschi C:
Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2).
Eur J Hum Genet. 1998; 6: 534-41.
PubMed (ID: 9887369), doi:10.1038/sj.ejhg.5200222
MeSH Terms: Longevity/genetics; Poly(ADP-ribose) Polymerases/genetics; Renin/genetics; Superoxide Dismutase/genetics; Tyrosine 3-Monooxygenase/genetics - Melov S, Coskun P, Patel M, Tuinstra R, Cottrell B, Jun AS, Zastawny TH, Dizdaroglu M, Goodman SI, Huang TT, Miziorko H, Epstein CJ, Wallace DC:
Mitochondrial disease in superoxide dismutase 2 mutant mice.
Proc Natl Acad Sci USA. 1999; 96: 846-51.
PubMed (ID: 9927656), PubMed Central (ID: PMC15313)
MeSH Terms: Mitochondria, Heart/metabolism; Mitochondria, Muscle/metabolism; Mitochondrial Myopathies/genetics; Oxidative Phosphorylation; Superoxide Dismutase/deficiency; Superoxide Dismutase/genetics - Hiroi S, Harada H, Nishi H, Satoh M, Nagai R, Kimura A:
Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese.
Biochem Biophys Res Commun. 1999; 261: 332-9.
PubMed (ID: 10425186), doi:10.1006/bbrc.1999.1036
MeSH Terms: Cardiomyopathy, Dilated/genetics; HLA-DR Antigens/genetics; Polymorphism, Genetic; Superoxide Dismutase/genetics - Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow GJ:
Extension of life-span with superoxide dismutase/catalase mimetics.
Science. 2000; 289: 1567-9.
PubMed (ID: 10968795)
MeSH Terms: Aging/drug effects; Antioxidants/pharmacology; Caenorhabditis elegans/physiology; Catalase/metabolism; Superoxide Dismutase/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot