Gene: Ins2 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Ins2 | ||||||||||||||||||||
NCBI Gene ID | : | 16334 | ||||||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||||||
Gene Synonyms | : | Ins-2 | Ins2 | InsII | insulin II | insulin-2 | Mody | Mody4 | proinsulin Source: GPSDB |
||||||||||||||||||||
Gene Homologs | : | INS (Bos taurus) | INS (Canis lupus familiaris) | ins (Danio rerio) | INS (Gallus gallus) | INS (Homo sapiens) | INS (Pan troglodytes) | Ins2 (Mus musculus) | Ins2 (Rattus norvegicus) | ||||||||||||||||||||
Ageing Relevance Analysis | : |
|
||||||||||||||||||||
Ageing Factor Stable ID | : | AF_000822 | ||||||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Insulin-2 | Mus musculus | P01326 (UniProtKB/Swiss-Prot) | INS2_MOUSE (UniProtKB/Swiss-Prot) | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | View |
Insulin II | Mus musculus | Q5EEX1 (UniProtKB/TrEMBL) | Q5EEX1_MOUSE (UniProtKB/TrEMBL) | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | |||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | |||||||||||||||||||||
1 | OB_000042 | Mus musculus |
|
decreased | days | median | female | Unlike Ins2(Akita/+) littermates, male Pparg(P465L/+)Ins2(Akita/+)mice have drastically reduced life-span with enhanced Type I diabetes. The Ins2-Akita mutation causes improper protein folding and islet apoptosis to lower plasma insulin. The Pparg(P465L) mutation is dominant negative. | Pendse et al. | 2010 | 20724579 | doi:10.2337/db10-0673 | Lifespan Observations Database (ID: 1038) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_008620 |
|
2 | The HomoloGene homology group 173 contains 2 genes with experimental evidence for ageing relevance (INS - Homo sapiens | Ins2 - Mus musculus) and 6 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 173 |
Sequences
INS2_MOUSE | P01326 | Insulin-2 (Mus musculus) from UniProtKB/Swiss-Prot Length: 110 10 20 30 40 50 60 70 80 90 100 110 INS2_MOUSE 1 MALWMRFLPLLALLFLWESHPTQAFVKQHLCGSHLVEALYLVCGERGFFYTPMSRREVEDPQVAQLELGGGPGAGDLQTLALEVAQQKRGIVDQCCTSICSLYQLENYCN 110
Q5EEX1_MOUSE | Q5EEX1 | Insulin II (Mus musculus) from UniProtKB/TrEMBL Length: 110 10 20 30 40 50 60 70 80 90 100 110 Q5EEX1_MOUSE 1 MALWMRFLPLLALLFLWESHPTQAFVKQHLCGSHLVEALYLVCGERGFFYTPMSRREVEDPQVAQLELGGGPGAGDLQTLALEVAQQKRGIVDQCCTSICSLYQLENYCN 110
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Pendse AA, Johnson LA, Tsai YS, Maeda N:
Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.
Diabetes. 2010; 59: 2890-7.
PubMed (ID: 20724579), PubMed Central (ID: PMC2963548), doi:10.2337/db10-0673
MeSH Terms: Adipose Tissue/metabolism; Hyperglycemia/genetics; Insulin Resistance/genetics; Mutation; PPAR gamma/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL