Gene: 14-3-3zeta - Drosophila melanogaster
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | 14-3-3zeta | ||||||||||||
NCBI Gene ID | : | 36059 | ||||||||||||
Species | : | Drosophila melanogaster | ||||||||||||
Gene Synonyms | : | 14-3-3 | 14-3-3 zeta | 14-3-3-zeta | 14-3-3EZ | 14-3-3leo | 14-3-3ZETA | 14-3-3zeta | 14-3-3zeta-PA | 14-3-3zeta-PB | 14-3-3zeta-PC | 14-3-3zeta-PD | 14-3-3zeta-PE | 14-3-3zeta-PF | 14-3-3zeta-PG | 14-3-3zeta-PH | 14-3-3zeta-PI | 14-3-3zeta-PJ | 14-3-3zeta-PK | 14-3-3zeta-PL | 2G1 | 4-3-3 zeta | 5.11 | CG17870 | CG17870 gene product from transcript CG17870-RE | CG17870-PA | CG17870-PB | CG17870-PC | CG17870-PD | CG17870-PE | CG17870-PF | CG17870-PG | CG17870-PH | CG17870-PI | CG17870-PJ | CG17870-PK | CG17870-PL | Complementation group K | complementation group K | D14 3 3 protein | D14-3-3 | D14-3-3zeta | d14-3-3zeta | Dmel_CG17870 | DmelCG17870 | l(2)07103 | l(2)46CFe | l(2)46Ee | LEO | Leo | leo | LEONARDO | Leonardo | leonardo | leonardo 14-3-3 | Leonardo-13-3-3 | PAR-5 | Par-5 | par-5 | PAR5 | THAP Source: GPSDB |
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Gene Homologs | : | 14-3-3zeta (Drosophila melanogaster) | AgaP_AGAP007643 (Anopheles gambiae) | ftt-2 (Caenorhabditis elegans) | LOC100855903 (Canis lupus familiaris) | par-5 (Caenorhabditis elegans) | ywhaqa (Danio rerio) | ywhaqb (Danio rerio) | YWHAZ (Gallus gallus) | YWHAZ (Homo sapiens) | YWHAZ (Macaca mulatta) | Ywhaz (Mus musculus) | YWHAZ (Pan troglodytes) | Ywhaz (Rattus norvegicus) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000911 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
14-3-3 protein zeta | Drosophila melanogaster | P29310 (UniProtKB/Swiss-Prot) | 1433Z_DROME (UniProtKB/Swiss-Prot) | Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development. Acts upstream of Raf and downstream of Ras, and is essential for viability. Acts as a negative regulator by decreasing its voltage sensitivity. Inhibits yki activity by restricting its nuclear localization. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008896 | 3 | The HomoloGene homology group 56528 contains 3 genes with experimental evidence for ageing relevance (YWHAZ - Homo sapiens | ftt-2 - Caenorhabditis elegans | par-5 - Caenorhabditis elegans) and 10 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 56528 |
Sequences
1433Z_DROME | P29310 | 14-3-3 protein zeta (Drosophila melanogaster) from UniProtKB/Swiss-Prot Length: 248 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 1433Z_DROME 1 MSTVDKEELVQKAKLAEQSERYDDMAQAMKSVTETGVELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTEASARKQQLAREYRERVEKELREICYEVLGLLDKYLIPKASNPESKVFYLKMKGDYYRYLAEVATGDARNTVVDDSQTAYQDAFDISKGKMQPTHPIRLGLALNFSVFYYEILNSPDKACQLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDTQGDEAEPQEGGDN 248
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot