Gene: Kcna3 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Kcna3 |
NCBI Gene ID |
: |
16491 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
Kca1-3 | Kcna3 | Kv1.3 | Mk-3 | MK3 | potassium voltage gated channel, shaker related subfamily, member 3 | potassium voltage-gated channel subfamily A member 3 | potassium voltage-gated channel, shaker-related subfamily, member 3 | Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3) | voltage-gated potassium channel subunit Kv1.3
Source: GPSDB |
Gene Homologs |
: |
KCNA3 (Bos taurus) | KCNA3 (Canis lupus familiaris) | KCNA3 (Gallus gallus) | KCNA3 (Homo sapiens) | KCNA3 (Macaca mulatta) | Kcna3 (Mus musculus) | KCNA3 (Pan troglodytes) | Kcna3 (Rattus norvegicus) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_000925 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Potassium voltage-gated channel subfamily A member 3 |
Mus musculus |
P16390 (UniProtKB/Swiss-Prot) |
KCNA3_MOUSE (UniProtKB/Swiss-Prot) |
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_006310 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Kcna3 |
16491 |
|
|
Kv1.3-null mice weigh less than their WT counterparts, have modified ingestive behaviors, are resistant to fat deposition following a moderately high-fat dietary regime and have improved longevity and fecundity. Moreover, gene-targeted deletion of Kv1.3 in MC4R-null mice (36% shorter lifespan compared to WT) returned the lifespan of these mice to approximately WT levels. |
18542083 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_006311 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Kcna3 |
Mus musculus |
16491 |
Deletion |
- |
wildtype |
yes |
|
|
|
increased |
22.00% |
|
|
|
Average |
|
|
|
Kv1.3-null mice weigh less than their WT counterparts, have modified ingestive behaviors, are resistant to fat deposition following a moderately high-fat dietary regime and have improved longevity and fecundity. Moreover, gene-targeted deletion of Kv1.3 in MC4R-null mice (36% shorter lifespan compared to WT) returned the lifespan of these mice to approximately WT levels. |
Tucker et al. |
2008 |
18542083 |
doi:10.1038/ijo.2008.77 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008183 |
|
2 |
The HomoloGene homology group 128570 contains 2 genes with experimental evidence for ageing relevance (KCNA3 - Homo sapiens | Kcna3 - Mus musculus) and 6 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 128570 |
Sequences
References
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources