Gene: Kl - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Kl |
NCBI Gene ID |
: |
16591 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
alpha-kl | Kl | klotho | secreted form of Klotho protein
Source: GPSDB |
Gene Homologs |
: |
KL (Bos taurus) | KL (Canis lupus familiaris) | KL (Gallus gallus) | KL (Homo sapiens) | Kl (Mus musculus) | KL (Pan troglodytes) | Kl (Rattus norvegicus) | LOC562316 (Danio rerio) | LOC714042 (Macaca mulatta) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
decreased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_000941 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005475 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Kl |
16591 |
|
|
Disruption results in infertility and signs of premature ageing such as a short lifespan, arteriosclerosis, skin atrophy, osteoporosis, and emphysema. |
9363890 |
GenAge |
2 |
OB_005478 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Kl |
16591 |
|
|
Many advanced ageing-like KL -/- phenotypes are restored to normal whenever Klotho expression is induced. Conversely, decreasing Klotho expression in these rescued KL -/- mice induced several ageing-like KL -/- phenotypes. |
16144705 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_002801 |
Mus musculus |
C57BL/6J and C3H/J mixed background |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Kl |
Mus musculus |
16591 |
loss of function |
- |
unknown |
unknown |
|
|
|
decreased |
-83.37% |
60.7 |
365 |
days |
mean |
21 |
℃ |
|
Disruption of Klotho results in a short lifespan by at least 85%. Experimental conditions: Also results in arteriosclerosis, skin atrophy, osteoporosis, and emphysema. |
Kuro-o et al. |
1997 |
9363890 |
doi:10.1038/36285 |
Lifespan Observations Database (ID: 4091) |
2 |
OB_005476 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Kl |
Mus musculus |
16591 |
Knockout |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Disruption results in infertility and signs of premature ageing such as a short lifespan, arteriosclerosis, skin atrophy, osteoporosis, and emphysema. |
Kuro-o et al. |
1997 |
9363890 |
doi:10.1038/36285 |
GenAge |
3 |
OB_005477 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Kl |
Mus musculus |
16591 |
Overexpression |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
Overexpression of Klotho in mice extends life span |
Kurosu et al. |
2005 |
16123266 |
doi:10.1126/science.1112766 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008226 |
|
2 |
The HomoloGene homology group 68415 contains 2 genes with experimental evidence for ageing relevance (KL - Homo sapiens | Kl - Mus musculus) and 7 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 68415 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI:
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
Nature. 1997; 390: 45-51.
PubMed (ID: 9363890), doi:10.1038/36285
MeSH Terms: Aging/genetics; Membrane Proteins/genetics
- Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M:
Suppression of aging in mice by the hormone Klotho.
Science. 2005; 309: 1829-33.
PubMed (ID: 16123266), PubMed Central (ID: PMC2536606), doi:10.1126/science.1112766
MeSH Terms: Aging/physiology; Longevity/physiology; Membrane Proteins/genetics; Membrane Proteins/physiology
- Masuda H, Chikuda H, Suga T, Kawaguchi H, Kuro-o M:
Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice.
Mech Ageing Dev. 2005; 126: 1274-83.
PubMed (ID: 16144705), doi:10.1016/j.mad.2005.07.007
MeSH Terms: Aging; Membrane Proteins/genetics
Sources
Ageing-related Data Sources
Additional Data Sources