Gene: PPARGC1A - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | PPARGC1A | ||||||||||||||||
NCBI Gene ID | : | 10891 | ||||||||||||||||
Species | : | Homo sapiens | ||||||||||||||||
Gene Synonyms | : | L-PGC-1alpha | LEM6 | ligand effect modulator-6 | peroxisome proliferative activated receptor, gamma, coactivator 1 | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4 | peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext | peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a | peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5 | peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT | peroxisome proliferator-activated receptor gamma coactivator 1-alpha | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA, COACTIVATOR 1 | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA, COACTIVATOR 1, ALPHA | PGC-1(alpha) | PGC-1-alpha | PGC-1v | PGC1 | PGC1-ALPHA | PGC1A | PPAR gamma coactivator variant form | PPAR-GAMMA COACTIVATOR 1 | PPAR-GAMMA COACTIVATOR 1-ALPHA | PPARGC-1-alpha | PPARGC1 | PPARGC1A Source: GPSDB |
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Gene Homologs | : | PPARGC1A (Bos taurus) | PPARGC1A (Canis lupus familiaris) | ppargc1a (Danio rerio) | PPARGC1A (Gallus gallus) | PPARGC1A (Homo sapiens) | PPARGC1A (Macaca mulatta) | Ppargc1a (Mus musculus) | PPARGC1A (Pan troglodytes) | Ppargc1a (Rattus norvegicus) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000949 | ||||||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | Homo sapiens | Q9UBK2 (UniProtKB/Swiss-Prot) | PRGC1_HUMAN (UniProtKB/Swiss-Prot) | Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. | View |
Peroxisome proliferative activated receptor, gamma, coactivator 1, alpha, isoform CRA_a | Homo sapiens | Q4W5M7 (UniProtKB/TrEMBL) | Q4W5M7_HUMAN (UniProtKB/TrEMBL) | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_009729 | Homo sapiens |
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PPARGC1A is a transcriptional coactivator that regulates and interacts with genes involved in energy metabolism [1847]. It may link external stimuli to the regulation of mitochondrial biogenesis. SIRT1 has been reported to be a functional regulator of PPARGC1A [1846]. In humans, PPARGC1A has been associated with cholesterol and obesity as well as age-related diseases like type 2 diabetes. | GenAge |
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009238 | 1 | The HomoloGene homology group 7485 contains 1 gene with experimental evidence for ageing relevance (PPARGC1A - Homo sapiens) and 8 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 7485 |
Sequences
PRGC1_HUMAN | Q9UBK2 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (Homo sapiens) from UniProtKB/Swiss-Prot Length: 798 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 PRGC1_HUMAN 1 MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQGNNSTKKGPEQSELYAQLSKSSVLTGGHEERKTKRPSLRLFGDHDYCQSINSKTEILINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDEADKTGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESERAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR 798
Q4W5M7_HUMAN | Q4W5M7 | Peroxisome proliferative activated receptor, gamma, coactivator 1, alpha, isoform CRA_a (Homo sapiens) from UniProtKB/TrEMBL Length: 798 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 Q4W5M7_HUMAN 1 MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQGNNSTKKGPEQSELYAQLSKSSVLTGGHEERKTKRPSLRLFGDHDYCQSINSKTEILINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDEADKTGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESERAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR 798
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM:
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
Nature. 2001; 413: 131-8.
PubMed (ID: 11557972), doi:10.1038/35093050
MeSH Terms: Blood Glucose/metabolism; DNA-Binding Proteins; Gluconeogenesis; Liver/metabolism; Transcription Factors/physiology - Liu C, Li S, Liu T, Borjigin J, Lin JD:
Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism.
Nature. 2007; 447: 477-81.
PubMed (ID: 17476214), doi:10.1038/nature05767
MeSH Terms: Biological Clocks/genetics; Energy Metabolism/genetics; Gene Expression Regulation/genetics; Trans-Activators/metabolism; Transcription, Genetic/genetics - Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH:
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
EMBO J. 2007; 26: 3169-79.
PubMed (ID: 17581637), PubMed Central (ID: PMC1914106), doi:10.1038/sj.emboj.7601758
MeSH Terms: Alzheimer Disease/metabolism; Amyotrophic Lateral Sclerosis/metabolism; Nerve Degeneration/metabolism; Sirtuins/metabolism - Katic M, Kennedy AR, Leykin I, Norris A, McGettrick A, Gesta S, Russell SJ, Bluher M, Maratos-Flier E, Kahn CR:
Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice.
Aging Cell. 2007; 6: 827-39.
PubMed (ID: 18001293), doi:10.1111/j.1474-9726.2007.00346.x
MeSH Terms: Adipose Tissue, White/metabolism; Gene Expression; Genes, Mitochondrial/genetics; Longevity/physiology; Mitochondria/metabolism; Thinness/metabolism - Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH:
Sirt1 protects against high-fat diet-induced metabolic damage.
Proc Natl Acad Sci USA. 2008; 105: 9793-8.
PubMed (ID: 18599449), PubMed Central (ID: PMC2474520), doi:10.1073/pnas.0802917105
MeSH Terms: Dietary Fats/adverse effects; Metabolism; Nuclear Respiratory Factor 1/genetics; Sirtuins/physiology; Superoxide Dismutase/genetics - Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT:
Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging.
Proc Natl Acad Sci USA. 2009; 106: 20405-10.
PubMed (ID: 19918075), PubMed Central (ID: PMC2787152), doi:10.1073/pnas.0911570106
MeSH Terms: Aging/metabolism; Metabolic Diseases/prevention & control; Muscle, Skeletal/metabolism; Sarcopenia/prevention & control; Trans-Activators/metabolism - Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA:
Telomere dysfunction induces metabolic and mitochondrial compromise.
Nature. 2011; 470: 359-65.
PubMed (ID: 21307849), doi:10.1038/nature09787
MeSH Terms: Mitochondria/metabolism; Mitochondria/pathology; Telomere/metabolism; Telomere/pathology - Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M:
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.
Nature. 2001; 413: 179-83.
PubMed (ID: 11557984), doi:10.1038/35093131
MeSH Terms: Cyclic AMP Response Element-Binding Protein/physiology; Gluconeogenesis; Liver/metabolism; Transcription Factors/physiology - Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM:
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.
Nature. 2002; 418: 797-801.
PubMed (ID: 12181572), doi:10.1038/nature00904
MeSH Terms: Muscle Fibers, Slow-Twitch/metabolism; Muscle, Skeletal/metabolism; Transcription Factors/metabolism; Transcriptional Activation - Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, Bracale R, Valerio A, Francolini M, Moncada S, Carruba MO:
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.
Science. 2003; 299: 896-9.
PubMed (ID: 12574632), doi:10.1126/science.1079368
MeSH Terms: Adipocytes/metabolism; Mitochondria/metabolism; Mitochondrial Proteins; Nitric Oxide Synthase/metabolism; Nitric Oxide/physiology; Penicillamine/analogs & derivatives - Herzig S, Hedrick S, Morantte I, Koo SH, Galimi F, Montminy M:
CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma.
Nature. 2003; 426: 190-3.
PubMed (ID: 14614508), doi:10.1038/nature02110
MeSH Terms: Cyclic AMP Response Element-Binding Protein/metabolism; Gene Expression Regulation; Lipid Metabolism; Liver/metabolism; Receptors, Cytoplasmic and Nuclear/metabolism; Transcription Factors/metabolism - Melloul D, Stoffel M:
Regulation of transcriptional coactivator PGC-1alpha.
Sci Aging Knowledge Environ. 2004; 2004: pe9.
PubMed (ID: 14999129), doi:10.1126/sageke.2004.9.pe9
MeSH Terms: Transcription Factors/physiology - Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P:
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Nature. 2005; 434: 113-8.
PubMed (ID: 15744310), doi:10.1038/nature03354
MeSH Terms: Glucose/metabolism; Homeostasis; Sirtuins/metabolism; Trans-Activators/metabolism - Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, Spiegelman BM:
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.
Proc Natl Acad Sci USA. 2006; 103: 10086-91.
PubMed (ID: 16775082), PubMed Central (ID: PMC1502510), doi:10.1073/pnas.0603615103
MeSH Terms: Cardiac Output, Low/genetics; Cardiac Output, Low/metabolism; Gene Expression Regulation; Trans-Activators/metabolism - Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P:
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.
EMBO J. 2007; 26: 1913-23.
PubMed (ID: 17347648), PubMed Central (ID: PMC1847661), doi:10.1038/sj.emboj.7601633
MeSH Terms: 3-Hydroxyacyl CoA Dehydrogenases/metabolism; Acetyl-CoA C-Acyltransferase/metabolism; Carbon-Carbon Double Bond Isomerases/metabolism; Enoyl-CoA Hydratase/metabolism; Mitochondria, Muscle/metabolism; Racemases and Epimerases/metabolism; Sirtuins/metabolism; Trans-Activators/metabolism
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot
- UniProtKB/TrEMBL