Gene: ROM2 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | ROM2 | ||||||||||||||||||||||||
NCBI Gene ID | : | 851086 | ||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||
Gene Synonyms | : | L8039.3 | ROM2 | Rom2p | YLR371W Source: GPSDB |
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Gene Homologs | : | AGOS_AFR585W (Eremothecium gossypii) | KLLA0B07799g (Kluyveromyces lactis) | MGG_03064 (Magnaporthe oryzae) | NCU00668 (Neurospora crassa) | rgf1 (Schizosaccharomyces pombe) | ROM2 (Saccharomyces cerevisiae) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_000997 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_005813 | Saccharomyces cerevisiae |
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increased | 50.00% | unknown | Replicative lifespan increased by 50% in the alpha strain and 20% in a strain | Managbanag et al. | 2008 | 19030232 | doi:10.1371/journal.pone.0003802 | GenAge | |||||||||||||||||||||||
2 | OB_000056 | Saccharomyces cerevisiae | BY4742 |
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increased | 49.00% | divisions | mean | 30 | ℃ | matalpha | 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. | Kaeberlein et al. | 2005 | 16293764 | doi:10.1126/science.1115535 | Lifespan Observations Database (ID: 1057) | ||||||||||||||||||
3 | OB_005812 | Saccharomyces cerevisiae |
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increased | 30.00% | unknown | Deletion increased mean replicative lifespan by about 30%. | Kaeberlein et al. | 2005 | 16293764 | doi:10.1126/science.1115535 | GenAge | |||||||||||||||||||||||
4 | OB_000057 | Saccharomyces cerevisiae | BY4742 |
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increased | 16.00% | divisions | mean | 30 | ℃ | mata | 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. | Kaeberlein et al. | 2005 | 16293764 | doi:10.1126/science.1115535 | Lifespan Observations Database (ID: 1058) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_008848 | 1 | The HomoloGene homology group 34343 contains 1 gene with experimental evidence for ageing relevance (ROM2 - Saccharomyces cerevisiae) and 5 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 34343 |
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kaeberlein M, Powers RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK:
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Science. 2005; 310: 1193-6.
PubMed (ID: 16293764), doi:10.1126/science.1115535
MeSH Terms: Protein Kinases/metabolism; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/physiology - Managbanag JR, Witten TM, Bonchev D, Fox LA, Tsuchiya M, Kennedy BK, Kaeberlein M:
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.
PLoS ONE. 2008; 3: e3802.
PubMed (ID: 19030232), PubMed Central (ID: PMC2583956), doi:10.1371/journal.pone.0003802
MeSH Terms: Cell Physiological Phenomena/genetics; Gene Regulatory Networks; Saccharomyces cerevisiae/cytology; Saccharomyces cerevisiae/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed