Gene: Lmna - Rattus norvegicus
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Gene Symbol | : | Lmna | ||||||||||||
NCBI Gene ID | : | 60374 | ||||||||||||
Species | : | Rattus norvegicus | ||||||||||||
Gene Synonyms | : | lamin A | lamin A/C | lamin C2 | lamin-A | Lmn1 | Lmna | prelamin-A/C Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP008015 (Anopheles gambiae) | LMNA (Bos taurus) | LMNA (Canis lupus familiaris) | lmna (Danio rerio) | LMNA (Homo sapiens) | LMNA (Macaca mulatta) | Lmna (Mus musculus) | LMNA (Pan troglodytes) | Lmna (Rattus norvegicus) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_001108 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Prelamin-A/C | Rattus norvegicus | P48679 (UniProtKB/Swiss-Prot) | LMNA_RAT (UniProtKB/Swiss-Prot) | Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source | ||||||||||||||||||||||||||||||
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1 | OB_008576 |
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2 | The HomoloGene homology group 41321 contains 2 genes with experimental evidence for ageing relevance (LMNA - Homo sapiens | Lmna - Mus musculus) and 7 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 41321 |
Sequences
LMNA_RAT | P48679 | Prelamin-A/C (Rattus norvegicus) from UniProtKB/Swiss-Prot Length: 665 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 LMNA_RAT 1 METPSQRRPTRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLLAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQSQGGGSVTKKRKLESSESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLMTYRFPPKFTLKAGQVVTIWASGAGATHSPPTDLVWKAQNTWGCGTSLRTALINATGEEVAMRKLVRSLTMVEDNDDEEEDGDELLHHHRGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKAASGSGAQVGGSISSGSSASSVTVTRSFRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSSQNCSIM 665
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot