Gene: Msra - Mus musculus(see also ageing factor AF_009056 *)
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
Mitochondrial peptide methionine sulfoxide reductase |
Mus musculus |
Q9D6Y7 (UniProtKB/Swiss-Prot) |
MSRA_MOUSE (UniProtKB/Swiss-Prot) |
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_005588 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Msra |
Mus musculus |
110265 |
Knockout |
- |
wildtype |
yes |
|
|
|
decreased |
|
|
|
|
unknown |
|
|
|
Knockouts exhibit a shorter lifespan and enhanced sensitivity to oxidative stress. |
Moskovitz et al. |
2001 |
11606777 |
doi:10.1073/pnas.231472998 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008947 |
|
3 |
The HomoloGene homology group 5812 contains 3 genes with experimental evidence for ageing relevance (MSRA - Homo sapiens | MXR1 - Saccharomyces cerevisiae | Msra - Mus musculus) and 14 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 5812 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Moskovitz J, Bar-Noy S, Williams WM, Requena J, Berlett BS, Stadtman ER:
Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals.
Proc Natl Acad Sci USA. 2001; 98: 12920-5.
PubMed (ID: 11606777), PubMed Central (ID: PMC60800), doi:10.1073/pnas.231472998
MeSH Terms: Antioxidants/metabolism; Methionine/chemistry; Oxidoreductases/metabolism
- Salmon AB, Pérez VI, Bokov A, Jernigan A, Kim G, Zhao H, Levine RL, Richardson A:
Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span.
FASEB J. 2009; 23: 3601-8.
PubMed (ID: 19487311), PubMed Central (ID: PMC2747676), doi:10.1096/fj.08-127415
MeSH Terms: Longevity/genetics; Oxidative Stress/genetics; Oxidoreductases/metabolism
Sources
Ageing-related Data Sources
Additional Data Sources