Gene: Magoh - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Gene Symbol | : | Magoh | ||||||||||||
NCBI Gene ID | : | 17149 | ||||||||||||
Species | : | Mus musculus | ||||||||||||
Gene Synonyms | : | Mago-m | mago-nashi homolog, proliferation-associated (Drosophila) | Magoh | Mos2 | protein mago nashi homolog | RP23-40G2.2 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP010755 (Anopheles gambiae) | LOC100613301 (Pan troglodytes) | mag-1 (Caenorhabditis elegans) | mago (Drosophila melanogaster) | MAGOH (Bos taurus) | MAGOH (Canis lupus familiaris) | magoh (Danio rerio) | MAGOH (Gallus gallus) | MAGOH (Homo sapiens) | MAGOH (Macaca mulatta) | Magoh (Mus musculus) | Magoh (Rattus norvegicus) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_001270 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Protein mago nashi homolog | Mus musculus | P61327 (UniProtKB/Swiss-Prot) | MGN_MOUSE (UniProtKB/Swiss-Prot) | Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA after its export to the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_008467 | 1 | The HomoloGene homology group 1776 contains 1 gene with experimental evidence for ageing relevance (mag-1 - Caenorhabditis elegans) and 11 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 1776 |
Sequences
MGN_MOUSE | P61327 | Protein mago nashi homolog (Mus musculus) from UniProtKB/Swiss-Prot Length: 146 10 20 30 40 50 60 70 80 90 100 110 120 130 140 MGN_MOUSE 1 MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI 146
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot