Gene: Sod2 - Mus musculus(see also ageing factor AF_008914 *)
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | Sod2 | ||||||||||||||||
NCBI Gene ID | : | 20656 * | ||||||||||||||||
Species | : | Mus musculus | ||||||||||||||||
Gene Synonyms | : | manganese SOD | manganese superoxide dismutase | MnSOD | Sod-2 | Sod2 | superoxide dismutase 2, mitochondrial | superoxide dismutase [Mn], mitochondrial Source: GPSDB |
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Gene Homologs | : | KLLA0E03609g (Kluyveromyces lactis) | MGG_00212 (Magnaporthe oryzae) | MNSOD1 (Anopheles gambiae) | NCU09560 (Neurospora crassa) | Os05g0323900 (Oryza sativa) | sod-2 (Caenorhabditis elegans) | sod-3 (Caenorhabditis elegans) | SOD2 (Bos taurus) | SOD2 (Canis lupus familiaris) | sod2 (Danio rerio) | Sod2 (Drosophila melanogaster) | SOD2 (Gallus gallus) | SOD2 (Homo sapiens) | SOD2 (Macaca mulatta) | Sod2 (Mus musculus) | SOD2 (Pan troglodytes) | Sod2 (Rattus norvegicus) | SOD2 (Saccharomyces cerevisiae) | sod2 (Schizosaccharomyces pombe) | SODA (Arabidopsis thaliana) | ||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_001301 | ||||||||||||||||
Download | : | XML |
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AgeFactDB contains further genes associated with gene symbol Sod2 and the species Mus musculus: AF_008914
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
---|---|---|---|---|---|
Superoxide dismutase | Mus musculus | Q4FJX9 (UniProtKB/TrEMBL) | Q4FJX9_MOUSE (UniProtKB/TrEMBL) | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. | View |
Superoxide dismutase [Mn], mitochondrial | Mus musculus | P09671 (UniProtKB/Swiss-Prot) | SODM_MOUSE (UniProtKB/Swiss-Prot) | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. | View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | OB_006322 | Mus musculus |
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Gene deletion in connective tissue resulted in mutant mice with a reduced lifespan and premature onset of aging-related phenotypes such as weight loss, skin atrophy, kyphosis, osteoporosis and muscle degeneration. | 21108731 | GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_006323 | Mus musculus |
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decreased | -14.00% | maximum | Gene deletion in connective tissue resulted in mutant mice with a reduced lifespan and premature onset of aging-related phenotypes such as weight loss, skin atrophy, kyphosis, osteoporosis and muscle degeneration. | Treiber et al. | 2011 | 21108731 | doi:10.1111/j.1474-9726.2010.00658.x | GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
Sequences
Q4FJX9_MOUSE | Q4FJX9 | Superoxide dismutase (Mus musculus) from UniProtKB/TrEMBL Length: 222 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 Q4FJX9_MOUSE 1 MLCRAACSTGRRLGPVAGAAGSRHKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNATEEKYHEALAKGDVTTQVALQPALKFNGGGHINHTIFWTNLSPKGGGEPKGELLEAIKRDFGSFEKFKEKLTAVSVGVQGSGWGWLGFNKEQGRLQIAACSNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYTACKK 222
SODM_MOUSE | P09671 | Superoxide dismutase [Mn], mitochondrial (Mus musculus) from UniProtKB/Swiss-Prot Length: 222 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 SODM_MOUSE 1 MLCRAACSTGRRLGPVAGAAGSRHKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNATEEKYHEALAKGDVTTQVALQPALKFNGGGHINHTIFWTNLSPKGGGEPKGELLEAIKRDFGSFEKFKEKLTAVSVGVQGSGWGWLGFNKEQGRLQIAACSNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYTACKK 222
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Treiber N, Maity P, Singh K, Kohn M, Keist AF, Ferchiu F, Sante L, Frese S, Bloch W, Kreppel F, Kochanek S, Sindrilaru A, Iben S, Högel J, Ohnmacht M, Claes LE, Ignatius A, Chung JH, Lee MJ, Kamenisch Y, Berneburg M, Nikolaus T, Braunstein K, Sperfeld AD, Ludolph AC, Briviba K, Wlaschek M, Florin L, Angel P, Scharffetter-Kochanek K:
Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue.
Aging Cell. 2011; 10: 239-54.
PubMed (ID: 21108731), doi:10.1111/j.1474-9726.2010.00658.x
MeSH Terms: Aging/physiology; Connective Tissue/enzymology; Longevity/physiology; Mitochondria/enzymology; Phenotype; Superoxide Dismutase/deficiency
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- UniProtKB/TrEMBL
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed
- UniProtKB/Swiss-Prot