Gene: URE2 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | URE2 | ||||||||||||||||||||||||
NCBI Gene ID | : | 855492 | ||||||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||||||
Gene Synonyms | : | [URE3] | N1165 | URE2 | Ure2p | YNL229C Source: GPSDB |
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Gene Homologs | : | AGOS_ABL195C (Eremothecium gossypii) | gst1 (Schizosaccharomyces pombe) | gst2 (Schizosaccharomyces pombe) | KLLA0D19624g (Kluyveromyces lactis) | MGG_09138 (Magnaporthe oryzae) | NCU05780 (Neurospora crassa) | URE2 (Saccharomyces cerevisiae) | ||||||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_001326 | ||||||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_000067 | Saccharomyces cerevisiae | BY4741 |
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increased | 21.00% | divisions | mean | 30 | ℃ | mata | 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. | Kaeberlein et al. | 2005 | 16293764 | doi:10.1126/science.1115535 | Lifespan Observations Database (ID: 1067) | ||||||||||||||||||
2 | OB_006154 | Saccharomyces cerevisiae |
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increased | 20.00% | unknown | Deletion increased mean replicative lifespan by 20%. | Kaeberlein et al. | 2005 | 16293764 | doi:10.1126/science.1115535 | GenAge | |||||||||||||||||||||||
3 | OB_006155 | Saccharomyces cerevisiae |
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increased | 20.00% | unknown | Replicative lifespan increased by 20% in the alpha strain | Managbanag et al. | 2008 | 19030232 | doi:10.1371/journal.pone.0003802 | GenAge | |||||||||||||||||||||||
4 | OB_000068 | Saccharomyces cerevisiae | BY4742 |
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increased | 15.00% | divisions | mean | 30 | ℃ | matalpha | 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. | Kaeberlein et al. | 2005 | 16293764 | doi:10.1126/science.1115535 | Lifespan Observations Database (ID: 1068) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
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1 | OB_008359 | 1 | The HomoloGene homology group 22221 contains 1 gene with experimental evidence for ageing relevance (URE2 - Saccharomyces cerevisiae) and 6 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 22221 |
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Kaeberlein M, Powers RW, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK:
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Science. 2005; 310: 1193-6.
PubMed (ID: 16293764), doi:10.1126/science.1115535
MeSH Terms: Protein Kinases/metabolism; Saccharomyces cerevisiae Proteins/physiology; Saccharomyces cerevisiae/physiology - Managbanag JR, Witten TM, Bonchev D, Fox LA, Tsuchiya M, Kennedy BK, Kaeberlein M:
Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.
PLoS ONE. 2008; 3: e3802.
PubMed (ID: 19030232), PubMed Central (ID: PMC2583956), doi:10.1371/journal.pone.0003802
MeSH Terms: Cell Physiological Phenomena/genetics; Gene Regulatory Networks; Saccharomyces cerevisiae/cytology; Saccharomyces cerevisiae/genetics
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- NCBI Taxonomy
- PubMed