Gene: Sirt6 - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Sirt6 |
NCBI Gene ID |
: |
50721 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
NAD-dependent deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 | regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | Sir2l6 | Sirt6 | sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
Source: GPSDB |
Gene Homologs |
: |
AgaP_AGAP001458 (Anopheles gambiae) | NCU07624 (Neurospora crassa) | Os04g0271000 (Oryza sativa) | SIRT6 (Bos taurus) | SIRT6 (Canis lupus familiaris) | sirt6 (Danio rerio) | Sirt6 (Drosophila melanogaster) | SIRT6 (Gallus gallus) | SIRT6 (Homo sapiens) | SIRT6 (Macaca mulatta) | Sirt6 (Mus musculus) | SIRT6 (Pan troglodytes) | Sirt6 (Rattus norvegicus) | SRT1 (Arabidopsis thaliana) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
decreased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_001357 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
NAD-dependent protein deacetylase sirtuin-6 |
Mus musculus |
Q3UKP1 (UniProtKB/TrEMBL) |
Q3UKP1_MOUSE (UniProtKB/TrEMBL) |
|
View |
NAD-dependent protein deacetylase sirtuin-6 |
Mus musculus |
P59941 (UniProtKB/Swiss-Prot) |
SIR6_MOUSE (UniProtKB/Swiss-Prot) |
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (By similarity). Acts as a corepressor of the transcription factor Hif1a to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein. Has a role in the regulation of life span in male mice, but not in female mice. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005929 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Sirt6 |
50721 |
|
|
Knockout mice develop signs of premature ageing including a short lifespan. |
16439206 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_008240 |
|
3 |
The HomoloGene homology group 6924 contains 3 genes with experimental evidence for ageing relevance (SIRT6 - Homo sapiens | Sirt6 - Drosophila melanogaster | Sirt6 - Mus musculus) and 11 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 6924 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW:
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
Cell. 2006; 124: 315-29.
PubMed (ID: 16439206), doi:10.1016/j.cell.2005.11.044
MeSH Terms: Aging/metabolism; Genetic Diseases, Inborn/genetics; Genomic Instability; Sirtuins/genetics; Sirtuins/physiology
Sources
Ageing-related Data Sources
Additional Data Sources