Gene: NDE2 - Saccharomyces cerevisiae
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | NDE2 | ||||||||||||||||||||
NCBI Gene ID | : | 851474 | ||||||||||||||||||||
Species | : | Saccharomyces cerevisiae | ||||||||||||||||||||
Gene Synonyms | : | NADH-ubiquinone reductase (H(+)-translocating) NDE2 | NDE2 | Nde2p | NDH2 | YDL085W Source: GPSDB |
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Gene Homologs | : | |||||||||||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_001381 | ||||||||||||||||||||
Download | : | XML |
Protein Information
no protein information available
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# | Observation Stable ID | Species | Gene | Other Ageing Factor | Description | PubMed | Source | ||||||
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1 | OB_005609 | Saccharomyces cerevisiae |
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Overexpression of Nde1 and Nde2 resulted in a longer replicative lifespan (20-25%) on 2% glucose, but not on 0.5% glucose. | 14724176 | GenAge | |||||||
2 | OB_008011 | Saccharomyces cerevisiae |
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Overexpression of NDE1 and NDE2 increases intracellular NAD/NADH ratio by lowering NADH concentration and increases replicative lifespan by 20-25%. This lifespan extension is non-additive with 0.5% glucose restriction [ 14724176]. | 12124627 | GenDR |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Organism | Ageing Factor | Lifespan Observation | Reference | ||||||||||||||||||||||||||||||||
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# | Observation Stable ID | Species | Strain | Gene | Compound | Other Ageing Factor | Significant Lifespan Effect | Change | Observed Lifespan | Reference Lifespan | Lifespan Unit | Measure | Temperature | Temperature Unit | Sex/Mating Type | Description | Author | Year | PubMed | DOI | Source | ||||||||||||||
1 | OB_005610 | Saccharomyces cerevisiae |
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increased | 25.00% | unknown | Overexpression of Nde1 and Nde2 resulted in a longer replicative lifespan (20-25%) on 2% glucose, but not on 0.5% glucose. | Lin et al. | 2004 | 14724176 | doi:10.1101/gad.1164804 | GenAge | |||||||||||||||||||||||
2 | OB_003892 | Saccharomyces cerevisiae |
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none | Overexpression of Nde1 and Nde2 had no effect on 0.5% glucose. | Lin et al. | 2004 | 14724176 | doi:10.1101/gad.1164804 | Lifespan Observations Database (ID: 609) |
Homology Analysis
no homology analysis observation available
Sequences
no sequence information available
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, Guarente L:
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.
Nature. 2002; 418: 344-8.
PubMed (ID: 12124627), doi:10.1038/nature00829
MeSH Terms: Cell Aging/physiology; Cell Respiration; Energy Intake/physiology; Glucose/metabolism; Histone Deacetylases/metabolism; Saccharomyces cerevisiae/metabolism; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Trans-Activators/metabolism - Lin SJ, Ford E, Haigis M, Liszt G, Guarente L:
Calorie restriction extends yeast life span by lowering the level of NADH.
Genes Dev. 2004; 18: 12-6.
PubMed (ID: 14724176), PubMed Central (ID: PMC314267), doi:10.1101/gad.1164804
MeSH Terms: NAD/metabolism; Saccharomyces cerevisiae/growth & development
Sources
Ageing-related Data Sources
- AgeFactDB Curator
- GenAge
- GenDR
- Lifespan Observations Database
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- NCBI Taxonomy
- PubMed