Gene: Pparg - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Pparg |
NCBI Gene ID |
: |
19016 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
Nr1c3 | nuclear receptor subfamily 1 group C member 3 | peroxisome proliferator activated receptor gamma | peroxisome proliferator activated receptor gamma 2 | peroxisome proliferator activated receptor gamma 4 | peroxisome proliferator-activated receptor gamma | PPAR-gamma | PPAR-gamma2 | Ppar-gamma2 | Pparg | PPARgamma | PPARgamma2
Source: GPSDB |
Gene Homologs |
: |
PPARG (Bos taurus) | PPARG (Canis lupus familiaris) | pparg (Danio rerio) | PPARG (Gallus gallus) | PPARG (Homo sapiens) | PPARG (Macaca mulatta) | Pparg (Mus musculus) | PPARG (Pan troglodytes) | Pparg (Rattus norvegicus) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Ageing Phenotype Observation—Data Type 2 Lifespan Effect |
|
|
|
decreased |
1 |
yes (Exp. Analysis) |
Lifespan Observations Database |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) putative (Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
3 |
|
|
|
Ageing Factor Stable ID |
: |
AF_001488 |
Download |
: |
XML |
Protein Information
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_006312 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Pparg |
19016 |
|
|
On a chow diet, despite equal food intake, Ala/Ala knock-in mice display beneficial changes in fat mass, circulating lipids, and insulin sensitivity, compared to their Pro/Pro littermates. Ala/Ala mice also gained less weight than Pro/Pro mice both in fat and lean body mass, and their lifespan is average 13% longer. |
19117549 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_006313 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Pparg |
Mus musculus |
19016 |
Knockin |
- |
wildtype |
yes |
|
|
|
increased |
13.00% |
|
|
|
Average |
|
|
|
On a chow diet, despite equal food intake, Ala/Ala knock-in mice display beneficial changes in fat mass, circulating lipids, and insulin sensitivity, compared to their Pro/Pro littermates. Ala/Ala mice also gained less weight than Pro/Pro mice both in fat and lean body mass, and their lifespan is average 13% longer. |
Heikkinen et al. |
2009 |
19117549 |
doi:10.1016/j.cmet.2008.11.007 |
GenAge |
2 |
OB_006314 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Pparg |
Mus musculus |
19016 |
Mutations |
- |
wildtype |
yes |
|
|
|
decreased |
-11.00% |
|
|
|
Median |
|
|
|
Lowered expression of Pparg reduced lifespan in both the lipodystrophic Pparg1/2-hypomorphic and the Pparg2-deficient mice. |
Argmann et al. |
2009 |
19997628 |
doi:10.1371/journal.pgen.1000752 |
GenAge |
3 |
OB_000042 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Ins2 |
Mus musculus |
16334 |
unknown |
Akita |
unknown |
unknown |
Pparg |
Mus musculus |
19016 |
non-null dominant |
P465L |
unknown |
unknown |
|
|
|
decreased |
|
|
|
days |
median |
|
|
female |
Unlike Ins2(Akita/+) littermates, male Pparg(P465L/+)Ins2(Akita/+)mice have drastically reduced life-span with enhanced Type I diabetes. The Ins2-Akita mutation causes improper protein folding and islet apoptosis to lower plasma insulin. The Pparg(P465L) mutation is dominant negative. |
Pendse et al. |
2010 |
20724579 |
doi:10.2337/db10-0673 |
Lifespan Observations Database (ID: 1038) |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009297 |
|
2 |
The HomoloGene homology group 7899 contains 2 genes with experimental evidence for ageing relevance (PPARG - Homo sapiens | Pparg - Mus musculus) and 7 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 7899 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Heikkinen S, Argmann C, Feige JN, Koutnikova H, Champy MF, Dali-Youcef N, Schadt EE, Laakso M, Auwerx J:
The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface.
Cell Metab. 2009; 9: 88-98.
PubMed (ID: 19117549), doi:10.1016/j.cmet.2008.11.007
MeSH Terms: Amino Acid Substitution; Diet; Glucose/metabolism; PPAR gamma/genetics; PPAR gamma/physiology
- Argmann C, Dobrin R, Heikkinen S, Auburtin A, Pouilly L, Cock TA, Koutnikova H, Zhu J, Schadt EE, Auwerx J:
Ppargamma2 is a key driver of longevity in the mouse.
PLoS Genet. 2009; 5: e1000752.
PubMed (ID: 19997628), PubMed Central (ID: PMC2780700), doi:10.1371/journal.pgen.1000752
MeSH Terms: Longevity/genetics; PPAR gamma/genetics; PPAR gamma/metabolism
- Pendse AA, Johnson LA, Tsai YS, Maeda N:
Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.
Diabetes. 2010; 59: 2890-7.
PubMed (ID: 20724579), PubMed Central (ID: PMC2963548), doi:10.2337/db10-0673
MeSH Terms: Adipose Tissue/metabolism; Hyperglycemia/genetics; Insulin Resistance/genetics; Mutation; PPAR gamma/genetics
Sources
Ageing-related Data Sources
Additional Data Sources