Gene: Pawr - Mus musculus
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol |
: |
Pawr |
NCBI Gene ID |
: |
114774 |
Species |
: |
Mus musculus |
Gene Synonyms |
: |
Par-4 | PAR4 | Par4 | Pawr | PRKC apoptosis WT1 regulator protein | PRKC, apoptosis, WT1, regulator | prostate apoptosis response 4 protein
Source: GPSDB |
Gene Homologs |
: |
PAWR (Bos taurus) | PAWR (Canis lupus familiaris) | pawr (Danio rerio) | PAWR (Gallus gallus) | PAWR (Homo sapiens) | PAWR (Macaca mulatta) | Pawr (Mus musculus) | PAWR (Pan troglodytes) | Pawr (Rattus norvegicus) |
Ageing Relevance Analysis |
: |
Observation Type |
Count |
Ageing Relevance |
Source |
Ageing Phenotype Observation—Data Type 1 |
1 |
yes (Exp. Analysis) |
GenAge |
Homology Analysis |
1 |
- (basis for a Comp. Analysis) |
AgeFactDB Homology Analysis |
Total |
2 |
|
|
|
Ageing Factor Stable ID |
: |
AF_001561 |
Download |
: |
XML |
Protein Information
Protein Name |
Species |
UniProt Accession Number |
UniProt Entry Name |
Protein Function |
Sequence |
PRKC apoptosis WT1 regulator protein |
Mus musculus |
Q925B0 (UniProtKB/Swiss-Prot) |
PAWR_MOUSE (UniProtKB/Swiss-Prot) |
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. |
View |
Observations
Ageing Phenotype
Data Type 1
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
# |
Observation Stable ID |
Species |
Gene |
Other Ageing Factor |
Description |
PubMed |
Source |
1 |
OB_005696 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Pawr |
114774 |
|
|
Par4-null mice are prone to develop tumours, both spontaneously and on carcinogenic treatment. The endometrium and prostate of Par4-null mice were particularly sensitive to the development of proliferative lesions. Most (80%) Par4-null females presented endometrial hyperplasia by 9 months of age, and a significant proportion (36%) developed endometrial adenocarcinomas after 1 year of age. Similarly, Par4- null males showed a high incidence of prostate hyperplasia and prostatic intraepithelial neoplasias, and were extraordinarily sensitive to testosterone-induced prostate hyperplasia. 25% reduction in mean LS was observed compared to WT and 20% reduction in MLS. Heterozygote KOLS did not differ significantly from the WT. |
15877079 |
GenAge |
2 |
OB_005698 |
Mus musculus |
Gene Symbol |
NCBI Gene ID |
Pawr |
114774 |
|
|
Mice overexpressing the pro-apoptotic protein domain were resistant to tumours. Transgenic animals showed normal fertility, viability, and ageing, though they were slightly longer-lived possibly because of the cancer-resistance. |
17909035 |
GenAge |
Data Type 2
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
|
Organism |
Ageing Factor |
Lifespan Observation |
|
Reference |
# |
Observation Stable ID |
Species |
Strain |
Gene |
Compound |
Other Ageing Factor |
Significant Lifespan Effect |
Change |
Observed Lifespan |
Reference Lifespan |
Lifespan Unit |
Measure |
Temperature |
Temperature Unit |
Sex/Mating Type |
Description |
Author |
Year |
PubMed |
DOI |
Source |
1 |
OB_005697 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Pawr |
Mus musculus |
114774 |
Deletion |
- |
wildtype |
yes |
|
|
|
decreased |
-20.00% |
|
|
|
maximum |
|
|
|
Par4-null mice are prone to develop tumours, both spontaneously and on carcinogenic treatment. The endometrium and prostate of Par4-null mice were particularly sensitive to the development of proliferative lesions. Most (80%) Par4-null females presented endometrial hyperplasia by 9 months of age, and a significant proportion (36%) developed endometrial adenocarcinomas after 1 year of age. Similarly, Par4- null males showed a high incidence of prostate hyperplasia and prostatic intraepithelial neoplasias, and were extraordinarily sensitive to testosterone-induced prostate hyperplasia. 25% reduction in mean LS was observed compared to WT and 20% reduction in MLS. Heterozygote KOLS did not differ significantly from the WT. |
García-Cao et al. |
2005 |
15877079 |
doi:10.1038/sj.embor.7400421 |
GenAge |
2 |
OB_005699 |
Mus musculus |
|
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Pawr |
Mus musculus |
114774 |
Overexpression |
- |
wildtype |
yes |
|
|
|
increased |
|
|
|
|
unknown |
|
|
|
Mice overexpressing the pro-apoptotic protein domain were resistant to tumours. Transgenic animals showed normal fertility, viability, and ageing, though they were slightly longer-lived possibly because of the cancer-resistance. |
Zhao et al. |
2007 |
17909035 |
doi:10.1158/0008-5472.CAN-07-2124 |
GenAge |
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# |
Observation Stable ID |
Homology Group Genes |
#EGHG |
Description |
Source |
Homology Source |
1 |
OB_009312 |
|
1 |
The HomoloGene homology group 1940 contains 1 gene with experimental evidence for ageing relevance (Pawr - Mus musculus) and 8 other genes. |
AgeFactDB Homology Analysis |
HomoloGene homology group 1940 |
Sequences
References
MeSH Terms:
Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms.
They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page.
MeSH terms that belong to the Ageing MeSH are highlighted in green.
- García-Cao I, Duran A, Collado M, Carrascosa MJ, Martín-Caballero J, Flores JM, Diaz-Meco MT, Moscat J, Serrano M:
Tumour-suppression activity of the proapoptotic regulator Par4.
EMBO Rep. 2005; 6: 577-83.
PubMed (ID: 15877079), PubMed Central (ID: PMC1369092), doi:10.1038/sj.embor.7400421
MeSH Terms: Apoptosis/physiology; Endometrial Neoplasms/metabolism; Phenotype; Prostatic Neoplasms/metabolism; Proteins/metabolism; Receptors, Thrombin/metabolism; Urinary Bladder Neoplasms/metabolism
- Zhao Y, Burikhanov R, Qiu S, Lele SM, Jennings CD, Bondada S, Spear B, Rangnekar VM:
Cancer resistance in transgenic mice expressing the SAC module of Par-4.
Cancer Res. 2007; 67: 9276-85.
PubMed (ID: 17909035), doi:10.1158/0008-5472.CAN-07-2124
MeSH Terms: Neoplasms, Experimental/genetics; Neoplasms, Experimental/prevention & control; Receptors, Proteinase-Activated/biosynthesis
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
- GenAge
Additional Data Sources