Gene: VRK1 - Homo sapiens
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Gene Symbol | : | VRK1 | ||||||||||||
NCBI Gene ID | : | 7443 | ||||||||||||
Species | : | Homo sapiens | ||||||||||||
Gene Synonyms | : | PCH1 | PCH1A | serine/threonine-protein kinase VRK1 | vaccinia related kinase 1 | VACCINIA VIRUS B1R-RELATED KINASE 1 | vaccinia virus B1R-related kinase 1 | VACCINIA-RELATED KINASE 1 | vaccinia-related kinase 1 | VRK1 Source: GPSDB |
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Gene Homologs | : | AgaP_AGAP001933 (Anopheles gambiae) | ball (Drosophila melanogaster) | LOC794952 (Danio rerio) | vrk-1 (Caenorhabditis elegans) | VRK1 (Bos taurus) | VRK1 (Canis lupus familiaris) | vrk1 (Danio rerio) | VRK1 (Gallus gallus) | VRK1 (Homo sapiens) | VRK1 (Macaca mulatta) | Vrk1 (Mus musculus) | VRK1 (Pan troglodytes) | Vrk1 (Rattus norvegicus) | ||||||||||||
Ageing Relevance Analysis | : |
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Ageing Factor Stable ID | : | AF_001570 | ||||||||||||
Download | : | XML |
Protein Information
Protein Name | Species | UniProt Accession Number | UniProt Entry Name | Protein Function | Sequence |
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Serine/threonine-protein kinase VRK1 | Homo sapiens | Q99986 (UniProtKB/Swiss-Prot) | VRK1_HUMAN (UniProtKB/Swiss-Prot) | Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. | View |
Observations
Ageing Phenotype
Data Type 1
no ageing phenotype observation—data type 1 available
Data Type 2
no ageing phenotype observation—data type 2 available
Homology Analysis
Ageing Relevance:
- yes (Exp. Analysis)
- yes, but no ageing factor assigned (Exp. Analysis)
- no (Exp. Analysis)
- putative (Comp. Analysis)
Legend:
- #EGHG:
- Number of Experimentally Confirmed Ageing-related Genes In Homology Group
# | Observation Stable ID | Homology Group Genes | #EGHG | Description | Source | Homology Source |
---|---|---|---|---|---|---|
1 | OB_009316 | 1 | The HomoloGene homology group 2541 contains 1 gene with experimental evidence for ageing relevance (vrk-1 - Caenorhabditis elegans) and 12 other genes. | AgeFactDB Homology Analysis | HomoloGene homology group 2541 |
Sequences
VRK1_HUMAN | Q99986 | Serine/threonine-protein kinase VRK1 (Homo sapiens) from UniProtKB/Swiss-Prot Length: 396 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 VRK1_HUMAN 1 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKKEIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK 396
References
no reference information available
Sources
Ageing-related Data Sources
- AgeFactDB Homology Analysis
Additional Data Sources
- AgeFactDB Pipeline
- GPSDB
- HomoloGene
- UniProtKB/Swiss-Prot